Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings

• Published in: Journal of neurovirology Vol. 17; no. 3; pp. 239 - 247
• Main Authors: Gupta, Saurabh, Bousman, Chad A., Chana, Gursharan, Cherner, Mariana, Heaton, Robert K., Deutsch, Reena, Ellis, Ronald J., Grant, Igor, Everall, Ian P.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2011; Springer
• Subjects: Adult; Alleles; Amphetamine-Related Disorders - etiology; Amphetamine-Related Disorders - genetics; Amphetamine-Related Disorders - metabolism; Amphetamine-Related Disorders - psychology; Amphetamine-Related Disorders - virology; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cognition Disorders - etiology; Cognition Disorders - genetics; Cognition Disorders - metabolism; Cognition Disorders - psychology; Cognition Disorders - virology; Dopamine - metabolism; Genetic Predisposition to Disease; Genotype; HIV - physiology; HIV Infections - complications; HIV Infections - genetics; HIV Infections - metabolism; HIV Infections - virology; Human immunodeficiency virus; Human viral diseases; Humans; Immunology; Infectious Diseases; Male; Medical sciences; Methamphetamine - adverse effects; Methamphetamine - pharmacology; Neurology; Neuropsychological Tests; Neurosciences; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Dopamine D3 - genetics; Receptors, Dopamine D3 - metabolism; Retrospective Studies; Risk Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral diseases of the nervous system; Virology; HIV; SNP; Dopamine D3 receptor; Methamphetamine; Cognitive impairment; Human; Drug addiction; Nervous system diseases; Cognitive disorder; Metamfetamine; D3 Dopamine receptor; Infection; Viral disease; Polymorphism

Macrophages are one of HIV-1’s principal targets and chiefly responsible for translocating HIV into the central nervous system (CNS). Previous research suggested an increase in macrophages being infected by HIV in the presence of methamphetamine (METH) or increased extracellular dopamine (DA). Exper...