Optimized Acellular Nerve Graft Is Immunologically Tolerated and Supports Regeneration

• Published in: Tissue engineering Vol. 10; no. 11-12; pp. 1641 - 1651
• Main Authors: Hudson, Terry W., Zawko, Scott, Deister, Curt, Lundy, Scott, Hu, Char Y., Lee, Kate, Schmidt, Christine E.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.11.2004
• Subjects: Animals; Cell-Free System - immunology; Cell-Free System - transplantation; Graft Rejection - immunology; Graft Rejection - prevention & control; Guided Tissue Regeneration - adverse effects; Guided Tissue Regeneration - methods; Immunology; Male; Nerve Regeneration - immunology; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve - immunology; Sciatic Nerve - injuries; Sciatic Nerve - pathology; Sciatic Nerve - surgery; Sciatic Nerve - transplantation; Skin & tissue grafts; Tissue Culture Techniques; Tissue engineering; Tissue Transplantation - adverse effects; Tissue Transplantation - methods; Transplants - adverse effects; Treatment Outcome

To replace the autologous graft as a clinical treatment of peripheral nerve injuries we developed an optimized acellular (OA) nerve graft that retains the extracellular structure of peripheral nerve tissue via an improved chemical decellularization treatment. The process removes cellular membranes f...