Integrating biologically inspired nanomaterials and table-top stereolithography for 3D printed biomimetic osteochondral scaffolds

• Published in: Nanoscale Vol. 7; no. 33; pp. 141 - 1422
• Main Authors: Castro, Nathan J, O'Brien, Joseph, Zhang, Lijie Grace
• Format: Journal Article
• Language: English
• Published: England 07.09.2015
• Subjects: Biocompatibility; Biomedical materials; Biomimetic Materials - chemistry; Biomimetic Materials - metabolism; Biomimetic Materials - pharmacology; Biomimetics; Cell Adhesion - drug effects; Cell Culture Techniques; Cell Differentiation - drug effects; Cells, Cultured; Chondrogenesis - drug effects; Differentiation; Durapatite; Humans; Lactic Acid - chemistry; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Nanospheres; Nanostructure; Nanostructures - chemistry; Nanostructures - ultrastructure; Osteogenesis - drug effects; Polyethylene Glycols - chemistry; Polyglycolic Acid - chemistry; Porosity; Scaffolds; Three dimensional; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta1 - chemistry

The osteochondral interface of an arthritic joint is notoriously difficult to regenerate due to its extremely poor regenerative capacity and complex stratified architecture. Native osteochondral tissue extracellular matrix is composed of numerous nanoscale organic and inorganic constituents. Althoug...