Structure of a Voltage-Dependent K+ Channel β Subunit

• Published in: Cell Vol. 97; no. 7; pp. 943 - 952
• Main Authors: Gulbis, Jacqueline M, Mann, Sabine, MacKinnon, Roderick
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.06.1999
• Subjects: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Electric Conductivity; Humans; Models, Molecular; Molecular Sequence Data; Potassium Channels - chemistry; Protein Conformation; Sequence Homology, Amino Acid

The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the β subunit. One function of β subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian β subunits by X-ray crystallogr...