Structure of a Voltage-Dependent K+ Channel β Subunit
The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the β subunit. One function of β subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian β subunits by X-ray crystallogr...
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| Published in | Cell Vol. 97; no. 7; pp. 943 - 952 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
25.06.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the β subunit. One function of β subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian β subunits by X-ray crystallography at 2.8 Å resolution. Like the integral membrane component of K+ channels, β subunits form a four-fold symmetric structure. Each subunit is an oxido-reductase enzyme complete with a nicotinamide cofactor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel’s voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell. |
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| AbstractList | The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function of beta subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian beta subunits by X-ray crystallography at 2.8 A resolution. Like the integral membrane component of K+ channels, beta subunits form a four-fold symmetric structure. Each subunit is an oxidoreductase enzyme complete with a nicotinamide co-factor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel's voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell. The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the β subunit. One function of β subunits is to modify K+ channel gating. We have determined the structure of the conserved core of mammalian β subunits by X-ray crystallography at 2.8 Å resolution. Like the integral membrane component of K+ channels, β subunits form a four-fold symmetric structure. Each subunit is an oxido-reductase enzyme complete with a nicotinamide cofactor in its active site. Several structural features of the enzyme active site, including its location with respect to the four-fold axis, imply that it may interact directly or indirectly with the K+ channel’s voltage sensor. This structure suggests a mechanism for coupling membrane electrical excitability directly to chemistry of the cell. |
| Author | MacKinnon, Roderick Gulbis, Jacqueline M Mann, Sabine |
| Author_xml | – sequence: 1 givenname: Jacqueline M surname: Gulbis fullname: Gulbis, Jacqueline M organization: Laboratory of Molecular Neurobiology and Biophysics, and the Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA – sequence: 2 givenname: Sabine surname: Mann fullname: Mann, Sabine organization: Laboratory of Molecular Neurobiology and Biophysics, and the Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA – sequence: 3 givenname: Roderick surname: MacKinnon fullname: MacKinnon, Roderick email: mackinn@rockvax.rockefeller.edu organization: Laboratory of Molecular Neurobiology and Biophysics, and the Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10399921$$D View this record in MEDLINE/PubMed |
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| Snippet | The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the β subunit. One function of β... The integral membrane subunits of many voltage-dependent potassium channels are associated with an additional protein known as the beta subunit. One function... |
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| SubjectTerms | Amino Acid Sequence Animals Binding Sites Crystallography, X-Ray Electric Conductivity Humans Models, Molecular Molecular Sequence Data Potassium Channels - chemistry Protein Conformation Sequence Homology, Amino Acid |
| Title | Structure of a Voltage-Dependent K+ Channel β Subunit |
| URI | https://dx.doi.org/10.1016/S0092-8674(00)80805-3 https://www.ncbi.nlm.nih.gov/pubmed/10399921 https://search.proquest.com/docview/69879422 |
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