Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization

• Published in: Cancer causes & control Vol. 23; no. 6; pp. 865 - 873
• Main Authors: Matsuda, Yasunori, Yamashita, Satoshi, Lee, Yi-Chia, Niwa, Tohru, Yoshida, Takeichi, Gyobu, Ken, Igaki, Hiroyasu, Kushima, Ryoji, Lee, Shigeru, Wu, Ming-Shiang, Osugi, Harushi, Suehiro, Shigefumi, Ushijima, Toshikazu
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.06.2012; Springer Netherlands; Springer Nature B.V
• Subjects: Age; Alcohols; Alu Elements; Antigens; Antigens, Neoplasm - genetics; Average age; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer; Cancer Research; Cancer therapies; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - pathology; CpG Islands; DNA Methylation; Endoscopy; Epidemiology; Epigenetics; Epigenomics; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Female; Genetic Predisposition to Disease; Hematology; Hospitals; Humans; Long Interspersed Nucleotide Elements - genetics; Male; Medicine; Methylation; Middle Aged; Mucous Membrane - metabolism; Mucous Membrane - pathology; Neoplasm Proteins - genetics; Nucleocytoplasmic Transport Proteins - genetics; Oncology; Original Paper; P values; Polymerase chain reaction; Promoter Regions, Genetic; Public Health; Repetitive Sequences, Nucleic Acid; Squamous cell carcinoma; Surgery; Tumors; Japan; Taiwan; Epigenetics; Repetitive element; Esophageal squamous cell carcinoma; Hypomethylation; Cancer/testis antigen

Background: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs).Such hypermethylation is also present in normalappearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other h...