Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization

Background: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs).Such hypermethylation is also present in normalappearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other h...

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Published inCancer causes & control Vol. 23; no. 6; pp. 865 - 873
Main Authors Matsuda, Yasunori, Yamashita, Satoshi, Lee, Yi-Chia, Niwa, Tohru, Yoshida, Takeichi, Gyobu, Ken, Igaki, Hiroyasu, Kushima, Ryoji, Lee, Shigeru, Wu, Ming-Shiang, Osugi, Harushi, Suehiro, Shigefumi, Ushijima, Toshikazu
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.06.2012
Springer Netherlands
Springer Nature B.V
Subjects
Age
Alcohols
Alu Elements
Antigens
Antigens, Neoplasm - genetics
Average age
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer
Cancer Research
Cancer therapies
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
CpG Islands
DNA Methylation
Endoscopy
Epidemiology
Epigenetics
Epigenomics
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Female
Genetic Predisposition to Disease
Hematology
Hospitals
Humans
Long Interspersed Nucleotide Elements - genetics
Male
Medicine
Methylation
Middle Aged
Mucous Membrane - metabolism
Mucous Membrane - pathology
Neoplasm Proteins - genetics
Nucleocytoplasmic Transport Proteins - genetics
Oncology
Original Paper
P values
Polymerase chain reaction
Promoter Regions, Genetic
Public Health
Repetitive Sequences, Nucleic Acid
Squamous cell carcinoma
Surgery
Tumors
Japan
Taiwan
Epigenetics
Repetitive element
Esophageal squamous cell carcinoma
Hypomethylation
Cancer/testis antigen
Online AccessGet full text

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Abstract Background: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs).Such hypermethylation is also present in normalappearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. Method: We collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 noncancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes (NY-ESO-1, MAGE-CJ) were measured by bisulfite pyrosequencing and quantitative methylation-specifîc PCR, respectively. Results: Methylation levels of Alu, LINE1, NY-ESO-1, and MAGE-C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other. Conclusion: This is the first study to show the presence of global hypomethylation in ESCCs, and even in their noncancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.
AbstractList Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in normal-appearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. We collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 non-cancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes (NY-ESO-1, MAGE-C1) were measured by bisulfite pyrosequencing and quantitative methylation-specific PCR, respectively. Methylation levels of Alu, LINE1, NY-ESO-1, and MAGE-C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other. This is the first study to show the presence of global hypomethylation in ESCCs, and even in their non-cancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.[PUBLICATION ABSTRACT]
Background: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs).Such hypermethylation is also present in normalappearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. Method: We collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 noncancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes (NY-ESO-1, MAGE-CJ) were measured by bisulfite pyrosequencing and quantitative methylation-specifîc PCR, respectively. Results: Methylation levels of Alu, LINE1, NY-ESO-1, and MAGE-C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other. Conclusion: This is the first study to show the presence of global hypomethylation in ESCCs, and even in their noncancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.
Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in normal-appearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. We collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 non-cancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes (NY-ESO-1, MAGE-C1) were measured by bisulfite pyrosequencing and quantitative methylation-specific PCR, respectively. Methylation levels of Alu, LINE1, NY-ESO-1, and MAGE-C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other. This is the first study to show the presence of global hypomethylation in ESCCs, and even in their non-cancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.
BACKGROUNDAberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in normal-appearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown.METHODWe collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 non-cancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes (NY-ESO-1, MAGE-C1) were measured by bisulfite pyrosequencing and quantitative methylation-specific PCR, respectively.RESULTSMethylation levels of Alu, LINE1, NY-ESO-1, and MAGE-C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other.CONCLUSIONThis is the first study to show the presence of global hypomethylation in ESCCs, and even in their non-cancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.
Background Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in normal-appearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. Method We collected 184 samples of esophageal mucosae (95 normal mucosae from healthy subjects, and 89 non-cancerous background mucosae from ESCC patients) and 93 samples of ESCCs. Methylation levels of repetitive elements (Alu, LINE1) and cancer/testis antigen genes ( NY - ESO - 1 , MAGE - C1 ) were measured by bisulfite pyrosequencing and quantitative methylation-specific PCR, respectively. Results Methylation levels of Alu, LINE1, NY - ESO - 1 , and MAGE - C1 were significantly lower in ESCCs than in their background and normal mucosae. Also, in the background mucosae, a significant decrease of the Alu methylation level compared with the normal mucosae was present. In ESCCs, methylation levels of the two repetitive elements and the two cancer/testis antigen genes were correlated with each other. Conclusion This is the first study to show the presence of global hypomethylation in ESCCs, and even in their non-cancerous background mucosae. Alu hypomethylation might reflect the severity of an epigenetic field for cancerization.
Author Kushima, Ryoji
Suehiro, Shigefumi
Niwa, Tohru
Ushijima, Toshikazu
Gyobu, Ken
Igaki, Hiroyasu
Lee, Yi-Chia
Yoshida, Takeichi
Matsuda, Yasunori
Lee, Shigeru
Wu, Ming-Shiang
Osugi, Harushi
Yamashita, Satoshi
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22527164$$D View this record in MEDLINE/PubMed
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Keywords Epigenetics
Repetitive element
Esophageal squamous cell carcinoma
Hypomethylation
Cancer/testis antigen
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PublicationCentury 2000
PublicationDate 2012-06-01
PublicationDateYYYYMMDD 2012-06-01
PublicationDate_xml – month: 06
  year: 2012
  text: 2012-06-01
  day: 01
PublicationDecade 2010
PublicationPlace Dordrecht
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PublicationSubtitle An International Journal of Studies of Cancer in Human Populations
PublicationTitle Cancer causes & control
PublicationTitleAbbrev Cancer Causes Control
PublicationTitleAlternate Cancer Causes Control
PublicationYear 2012
Publisher Springer
Springer Netherlands
Springer Nature B.V
Publisher_xml – name: Springer
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Snippet Background: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs).Such hypermethylation is also present in...
Background Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in...
Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in...
BACKGROUNDAberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in...
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springer
jstor
SourceType Aggregation Database
Index Database
Publisher
StartPage 865
SubjectTerms Age
Alcohols
Alu Elements
Antigens
Antigens, Neoplasm - genetics
Average age
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer
Cancer Research
Cancer therapies
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
CpG Islands
DNA Methylation
Endoscopy
Epidemiology
Epigenetics
Epigenomics
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Female
Genetic Predisposition to Disease
Hematology
Hospitals
Humans
Long Interspersed Nucleotide Elements - genetics
Male
Medicine
Methylation
Middle Aged
Mucous Membrane - metabolism
Mucous Membrane - pathology
Neoplasm Proteins - genetics
Nucleocytoplasmic Transport Proteins - genetics
Oncology
Original Paper
P values
Polymerase chain reaction
Promoter Regions, Genetic
Public Health
Repetitive Sequences, Nucleic Acid
Squamous cell carcinoma
Surgery
Tumors
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Title Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization
URI https://www.jstor.org/stable/41485258
https://link.springer.com/article/10.1007/s10552-012-9955-4
https://www.ncbi.nlm.nih.gov/pubmed/22527164
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https://search.proquest.com/docview/1012746355
Volume 23
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