Distinct K+ conductive pathways are required for Cl- and K+ secretion across distal colonic epithelium

• Published in: American Journal of Physiology: Cell Physiology Vol. 291; no. 4; pp. C636 - C648
• Main Authors: Halm, Susan Troutman, Liao, Tianjiang, Halm, Dan R
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2006
• Subjects: Animals; Benzimidazoles - pharmacology; Carbachol - pharmacology; Cellular biology; Chlorides - antagonists & inhibitors; Chlorides - metabolism; Cholinergic Agonists - pharmacology; Colon; Colon - metabolism; Dinoprostone - pharmacology; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Female; Guinea Pigs; Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism; Intestinal Mucosa - metabolism; Male; Membranes; Osmolar Concentration; Potassium - antagonists & inhibitors; Potassium - metabolism; Potassium Channel Blockers - administration & dosage; Potassium Channel Blockers - pharmacology; Potassium Channels - drug effects; Potassium Channels - physiology; Pyrazoles - administration & dosage; Pyrazoles - pharmacology; Quaternary Ammonium Compounds - pharmacology; Rats; Rats, Sprague-Dawley; Studies; Tissue Distribution

Department of Neuroscience, Cell Biology, and Physiology, Wright State University Boonshoft School of Medicine, Dayton, Ohio Submitted 31 October 2005 ; accepted in final form 1 April 2006 Secretion of Cl – and K + in the colonic epithelium operates through a cellular mechanism requiring K + channel...