Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers - Otaru, Sofia; Imlimthan, Surachet; Sarparanta, Mirkka; Helariutta, Kerttuli; Wähälä, Kristiina; Airaksinen, Anu (Molecules (Basel, Switzerland), 2020)
Keywords: Animals; bioorthogonal chemistry; Blood Proteins - metabolism; Cycloaddition Reaction; Cyclooctanes - chemistry; Drug Stability; Female; Fluorides; Fluorine; Fluorine Radioisotopes - chemistry; Fluorine Radioisotopes - pharmacokinetics; fluorine-18; Humans; inverse electron-demand diels-alder ligation; Investigations; isotopic exchange; Magnetic Resonance Spectroscopy; Mice; Nanoparticles; positron emission tomography (pet), defluorination; Positron-Emission Tomography - methods; Prostheses; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - pharmacokinetics; Serum Albumin, Bovine - chemistry; Silicon - chemistry; silicon-based fluoride acceptor; tetrazine; Tissue Distribution; isotopic exchange; positron emission tomography (PET), defluorination; fluorine-18; silicon-based fluoride acceptor; inverse electron-demand Diels-Alder ligation; bioorthogonal chemistry; tetrazine