Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage

• Published in: Diabetes (New York, N.Y.) Vol. 47; no. 9; pp. 1392 - 1398
• Main Authors: Baqué, S, Montell, E, Guinovart, J J, Newgard, C B, Gómez-Foix, A M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.1998
• Subjects: Adenoviridae; Animals; Biological and medical sciences; Biological Transport; Cells, Cultured; Deoxyglucose - metabolism; Diabetes. Impaired glucose tolerance; DNA, Complementary; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Gene Expression; Genetic aspects; Genetic Vectors; Glucokinase - biosynthesis; Glucokinase - genetics; Glucose - metabolism; Glucosephosphates - metabolism; Glycogen - biosynthesis; Glycogen Synthase - biosynthesis; Humans; Insulin - pharmacology; Insulin resistance; Kinetics; Liver - enzymology; Medical sciences; Mice; Mice, Transgenic; Muscle cells; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Phosphorylases - biosynthesis; Rats; Recombinant Proteins - biosynthesis; Endocrinopathy; Human; Pancreatic hormone; Enzyme; Transferases; Glucose; Striated muscle; In vitro; Insulin; Target tissue resistance; Regulation(control); Storage; Enzymatic activity; Glucokinase

Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. S Baqué , E Montell , J J Guinovart , C B Newgard and A M Gómez-Foix Department de Bioquímica i Biologia Molecular, Universitat de Barce...