The Prognosis-Predictive and Immunoregulatory Role of SUMOylation Related Genes: Potential Novel Targets in Prostate Cancer Treatment

• Published in: International journal of molecular sciences Vol. 24; no. 17; p. 13603
• Main Authors: Sun, Jian-Xuan, An, Ye, Xiang, Jia-Cheng, Xu, Jin-Zhou, Hu, Jia, Wang, Shao-Gang, Xia, Qi-Dong
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Cancer; Cancer therapies; Care and treatment; Cell cycle; Chemotherapy; Disease; Drug therapy; Enzymes; Gene expression; Genes; Genetic aspects; Genomes; Immunotherapy; Medical prognosis; Metastasis; Nomograms; Phosphorylation; Prognosis; Prostate cancer; Proteins

SUMOylation is an important part of post-translational protein modifications and regulates thousands of proteins in a dynamic manner. The dysregulation of SUMOylation is detected in many cancers. However, the comprehensive role of SUMOylation in prostate cancer (PCa) remains unclear. Using 174 SUMOy...