A functional epitope of the pneumococcal surface adhesin A activates nasopharyngeal cells and increases bacterial internalization

• Published in: Microbial pathogenesis Vol. 44; no. 3; pp. 186 - 196
• Main Authors: Rajam, Gowrisankar, Phillips, Donald J., White, Elizabeth, Anderton, Julie, Hooper, Craig W., Sampson, Jacquelyn S., Carlone, George M., Ades, Edwin W., Romero-Steiner, Sandra
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.03.2008
• Subjects: Adhesins, Bacterial - pharmacology; Antibodies, Bacterial - immunology; Antibodies, Bacterial - pharmacology; Bacteria; Bacterial Adhesion - immunology; Cellular activation; Cytokines - physiology; Endocytosis - drug effects; Endocytosis - physiology; Epitopes - pharmacology; Lipoproteins - pharmacology; Microscopy, Electron, Transmission; Nasopharynx - cytology; Nasopharynx - microbiology; Peptides; Pneumococcal adherence and invasion; PsaA; Putative binding domains; Streptococcus mitis; Streptococcus pneumoniae; Streptococcus pneumoniae - chemistry; Streptococcus pyogenes; Putative binding domains; Pneumococcal adherence and invasion; Peptides; PsaA; Streptococcus pneumoniae; Cellular activation

Pneumococcal surface adhesin A (PsaA) is a putative pneumococcal (Pnc) adhesin known to bind to nasopharyngeal (NP) epithelial cells. This study evaluated the effect of peptides within a functional domain of PsaA on NP cells. Detroit 562 NP cells were treated with synthetic peptides derived from Psa...