Matrix metalloproteinases and their clinical relevance in urinary bladder cancer

• Published in: Nature reviews. Urology Vol. 8; no. 5; pp. 241 - 254
• Main Authors: Szarvas, Tibor, vom Dorp, Frank, Ergün, Süleyman, Rübben, Herbert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2011; Nature Publishing Group
• Subjects: 692/420/755; 692/53/2421; 692/699/67/589/1336; Animals; Bladder cancer; Diagnosis; Extracellular Matrix - drug effects; Extracellular Matrix - enzymology; Humans; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases - metabolism; Medicine; Medicine & Public Health; Physiological aspects; Protease Inhibitors - pharmacology; Proteases; review-article; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - enzymology; Urology; Germany

Matrix metalloproteinases (MMPs) are a family of enzymes that have a number of important functions, including regulation of the extracellular matrix, angiogenesis and apoptosis. MMP dysregulation has been implicated in several disease processes. In this Review, the authors describe the role of MMPs...