Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study

Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For...

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Published inInternational journal of molecular sciences Vol. 24; no. 17; p. 13456
Main Authors Donate-Correa, Javier, Martín-Núñez, Ernesto, Mora-Fernández, Carmen, González-Luis, Ainhoa, Martín-Olivera, Alberto, Navarro-González, Juan F.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Analysis
Atherosclerosis
Body mass index
Cardiovascular disease
Coronary heart disease
Coronary vessels
Development and progression
Diabetes
Diabetes therapy
Diabetics
Fibroblast growth factors
Kidney diseases
Kidneys
Longitudinal studies
Metabolic disorders
Mortality
Regression analysis
Signal transduction
Type 2 diabetes
Vein & artery diseases
Spain
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Abstract Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For this, we performed a cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD-incidence-matched, non-diabetic patients undergoing non-emergency diagnostic coronary angiography. All of them were non-albuminuric and with normal glomerular filtration rates. The concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. As expected, the serum Klotho concentration was lower in the T2DM group (12.3% lower, p = 0.04). However, within the group of patients with T2DM, those subjects with CAD presented significantly higher Klotho levels than those without significant coronary stenosis (314.5 (6.15–562.81) vs. 458.97 (275.2–667.2) pg/mL; p = 0.02). Multiple regression analysis revealed that serum Klotho was positively related with stenosis values exclusively in subjects with T2DM (adjusted R2 = 0.153, p < 0.01). Moreover, logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; p = 0.041). Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with the presence of significant CAD.
AbstractList Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For this, we performed a cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD-incidence-matched, non-diabetic patients undergoing non-emergency diagnostic coronary angiography. All of them were non-albuminuric and with normal glomerular filtration rates. The concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. As expected, the serum Klotho concentration was lower in the T2DM group (12.3% lower, p = 0.04). However, within the group of patients with T2DM, those subjects with CAD presented significantly higher Klotho levels than those without significant coronary stenosis (314.5 (6.15–562.81) vs. 458.97 (275.2–667.2) pg/mL; p = 0.02). Multiple regression analysis revealed that serum Klotho was positively related with stenosis values exclusively in subjects with T2DM (adjusted R2 = 0.153, p < 0.01). Moreover, logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; p = 0.041). Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with the presence of significant CAD.
Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For this, we performed a cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD-incidence-matched, non-diabetic patients undergoing non-emergency diagnostic coronary angiography. All of them were non-albuminuric and with normal glomerular filtration rates. The concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. As expected, the serum Klotho concentration was lower in the T2DM group (12.3% lower, p = 0.04). However, within the group of patients with T2DM, those subjects with CAD presented significantly higher Klotho levels than those without significant coronary stenosis (314.5 (6.15–562.81) vs. 458.97 (275.2–667.2) pg/mL; p = 0.02). Multiple regression analysis revealed that serum Klotho was positively related with stenosis values exclusively in subjects with T2DM (adjusted R2 = 0.153, p < 0.01). Moreover, logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; p = 0.041). Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with the presence of significant CAD.
Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For this, we performed a cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD-incidence-matched, non-diabetic patients undergoing non-emergency diagnostic coronary angiography. All of them were non-albuminuric and with normal glomerular filtration rates. The concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. As expected, the serum Klotho concentration was lower in the T2DM group (12.3% lower, p = 0.04). However, within the group of patients with T2DM, those subjects with CAD presented significantly higher Klotho levels than those without significant coronary stenosis (314.5 (6.15-562.81) vs. 458.97 (275.2-667.2) pg/mL; p = 0.02). Multiple regression analysis revealed that serum Klotho was positively related with stenosis values exclusively in subjects with T2DM (adjusted R2 = 0.153, p < 0.01). Moreover, logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; p = 0.041). Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with the presence of significant CAD.Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the relationship between Klotho levels and the coronary artery disease (CAD) burden in subjects with T2DM and preserved kidney function was analyzed. For this, we performed a cross-sectional case-control study involving 133 subjects with T2DM and 200 age-, sex- and CAD-incidence-matched, non-diabetic patients undergoing non-emergency diagnostic coronary angiography. All of them were non-albuminuric and with normal glomerular filtration rates. The concentrations of serum Klotho, fibroblast growth factor 23, and inflammatory markers were also measured. As expected, the serum Klotho concentration was lower in the T2DM group (12.3% lower, p = 0.04). However, within the group of patients with T2DM, those subjects with CAD presented significantly higher Klotho levels than those without significant coronary stenosis (314.5 (6.15-562.81) vs. 458.97 (275.2-667.2) pg/mL; p = 0.02). Multiple regression analysis revealed that serum Klotho was positively related with stenosis values exclusively in subjects with T2DM (adjusted R2 = 0.153, p < 0.01). Moreover, logistic regression analysis showed that Klotho was positively associated with the presence of significant CAD in the group of T2DM patients (OR: 1.001; p = 0.041). Our data suggest that higher levels of circulating Klotho in subjects with T2DM and preserved kidney function are associated with the presence of significant CAD.
Audience Academic
Author Martín-Núñez, Ernesto
González-Luis, Ainhoa
Mora-Fernández, Carmen
Donate-Correa, Javier
Martín-Olivera, Alberto
Navarro-González, Juan F.
AuthorAffiliation 2 GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, 39008 Santander, Spain
3 Instituto de Tecnologías Biomédicas, Universidad de La Laguna, 382500 Santa Cruz de Tenerife, Spain
4 RICORS2040 (RD21/0005/0013), Instituto de Salud Carlos III, 28029 Madrid, Spain
5 Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
1 Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain; emarnu87@gmail.com (E.M.-N.); carmenmora.fdez@gmail.com (C.M.-F.); ainhoa.gonaluz@gmail.com (A.G.-L.); olimarabe@gmail.com (A.M.-O.)
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CitedBy_id crossref_primary_10_1089_rej_2024_0064
crossref_primary_10_1038_s41598_024_80464_5
crossref_primary_10_1186_s12944_024_02172_3
Cites_doi 10.1021/bi500409n
10.1146/annurev-physiol-030212-183727
10.1016/j.diabres.2014.08.026
10.1161/HYPERTENSIONAHA.120.16635
10.2337/db10-1262
10.1136/jim-2017-000560
10.1111/joim.13021
10.1016/j.jjcc.2020.11.014
10.1186/s12882-019-1391-1
10.1038/s41598-021-95488-4
10.1016/j.cyto.2021.155443
10.1093/eurheartj/ehi376
10.1136/heartjnl-2013-304746
10.1016/j.diabet.2018.01.009
10.1159/000452880
10.1111/j.1532-5415.2011.03558.x
10.1371/journal.pone.0102984
10.1186/s12933-022-01640-3
10.1093/ndt/gft523
10.1016/bs.vh.2016.02.005
10.1038/ncomms2266
10.1016/j.kint.2022.11.023
10.1186/s13073-016-0303-2
10.2337/diaclin.26.2.77
10.1016/j.jdiacomp.2016.11.008
10.1016/j.jdiacomp.2015.09.013
10.1016/j.mad.2023.111789
10.1309/AJCPGPMAF7SFRBO4
10.1159/000346778
10.1159/000342117
10.1016/j.cyto.2023.156213
10.1136/heartjnl-2019-316243
10.1186/1475-2840-12-116
10.1038/ki.2011.423
10.1093/ndt/gfq537
10.1073/pnas.0709805104
10.1177/1479164113500680
10.1371/journal.pone.0056695
10.1007/s10157-012-0621-7
10.1016/j.atherosclerosis.2018.07.006
10.1111/j.1474-9726.2012.00796.x
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References Yoon (ref_38) 2012; 120
Wang (ref_34) 2012; 11
Roberts (ref_4) 2013; 10
Jouven (ref_5) 2005; 26
Hu (ref_8) 2013; 180
Ferri (ref_14) 2021; 11
Shimamura (ref_25) 2012; 16
Yoon (ref_39) 2011; 26
Hammes (ref_17) 2013; 12
Zhao (ref_35) 2011; 60
Nie (ref_9) 2017; 31
Pan (ref_15) 2018; 276
ref_12
Chen (ref_7) 2014; 53
Chen (ref_40) 2007; 104
ref_30
Mao (ref_22) 2023; 211
Kanbay (ref_23) 2021; 77
Liu (ref_28) 2017; 66
Aljama (ref_36) 2016; 101
Neves (ref_43) 2016; 8
Cuarental (ref_37) 2023; 103
Fard (ref_24) 2021; 141
Koga (ref_31) 2021; 77
Mao (ref_20) 2023; 167
Wu (ref_16) 2014; 106
Wang (ref_27) 2018; 2018
Shiels (ref_41) 2020; 287
Keles (ref_18) 2016; 30
Moncayo (ref_33) 2019; 45
Devaraj (ref_26) 2012; 137
Fowler (ref_2) 2008; 26
Semba (ref_21) 2011; 59
Lu (ref_11) 2017; 3
Castelblanco (ref_19) 2022; 21
ref_1
Karlsson (ref_42) 2012; 3
(ref_13) 2014; 100
ref_29
Pereira (ref_32) 2014; 29
Grant (ref_3) 2020; 106
Asai (ref_10) 2012; 81
Hu (ref_6) 2013; 75
References_xml – volume: 53
  start-page: 5579
  year: 2014
  ident: ref_7
  article-title: Identification of cleavage sites leading to the shed form of the anti-aging protein klotho
  publication-title: Biochemistry
  doi: 10.1021/bi500409n
– volume: 75
  start-page: 503
  year: 2013
  ident: ref_6
  article-title: Fibroblast growth factor 23 and Klotho: Physiology and pathophysiology of an endocrine network of mineral metabolism
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-030212-183727
– volume: 106
  start-page: 343
  year: 2014
  ident: ref_16
  article-title: The changes of serum sKlotho and NGAL levels and their correlation in type 2 diabetes mellitus patients with different stages of urinary albumin
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2014.08.026
– volume: 77
  start-page: 740
  year: 2021
  ident: ref_23
  article-title: Role of Klotho in the Development of Essential Hypertension
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.120.16635
– volume: 60
  start-page: 1907
  year: 2011
  ident: ref_35
  article-title: Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (Serine)536 phosphorylation
  publication-title: Diabetes
  doi: 10.2337/db10-1262
– volume: 66
  start-page: 669
  year: 2017
  ident: ref_28
  article-title: Plasma s-Klotho is related to kidney function and predicts adverse renal outcomes in patients with advanced chronic kidney disease
  publication-title: J. Investig. Med.
  doi: 10.1136/jim-2017-000560
– volume: 287
  start-page: 271
  year: 2020
  ident: ref_41
  article-title: The role of the microbiota in sedentary lifestyle disorders and ageing: Lessons from the animal kingdom
  publication-title: J. Intern. Med.
  doi: 10.1111/joim.13021
– volume: 2018
  start-page: 9481475
  year: 2018
  ident: ref_27
  article-title: Correlation between soluble alpha-klotho and renal function in patients with chronic kidney disease: A review and meta-analysis
  publication-title: Biomed. Res. Int.
– volume: 77
  start-page: 583
  year: 2021
  ident: ref_31
  article-title: Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease
  publication-title: J. Cardiol.
  doi: 10.1016/j.jjcc.2020.11.014
– ident: ref_29
  doi: 10.1186/s12882-019-1391-1
– volume: 11
  start-page: 15877
  year: 2021
  ident: ref_14
  article-title: Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-95488-4
– volume: 141
  start-page: 155443
  year: 2021
  ident: ref_24
  article-title: Klotho, FOXO1 and cytokines associations in patients with coronary artery disease
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2021.155443
– volume: 26
  start-page: 2142
  year: 2005
  ident: ref_5
  article-title: Diabetes, glucose level, and risk of sudden cardiac death
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehi376
– volume: 100
  start-page: 34
  year: 2014
  ident: ref_13
  article-title: Reduced Klotho is associated with the presence and severity of coronary artery disease
  publication-title: Heart
  doi: 10.1136/heartjnl-2013-304746
– volume: 45
  start-page: 589
  year: 2019
  ident: ref_33
  article-title: Circulating soluble klotho is not associated with an elevated ankle-brachial index as a surrogate marker of early arterial calcification in patients with type 1 diabetes mellitus and no evidence of renal dysfunction
  publication-title: Diabetes Metab.
  doi: 10.1016/j.diabet.2018.01.009
– volume: 3
  start-page: 15
  year: 2017
  ident: ref_11
  article-title: Klotho/FGF23 Axis in chronic kidney disease and cardiovascular disease
  publication-title: Kidney Dis.
  doi: 10.1159/000452880
– ident: ref_1
– volume: 59
  start-page: 1596
  year: 2011
  ident: ref_21
  article-title: Plasma klotho and cardiovascular disease in adults
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.2011.03558.x
– ident: ref_30
  doi: 10.1371/journal.pone.0102984
– volume: 21
  start-page: 207
  year: 2022
  ident: ref_19
  article-title: Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus
  publication-title: Cardiovasc. Diabetol.
  doi: 10.1186/s12933-022-01640-3
– volume: 29
  start-page: 1525
  year: 2014
  ident: ref_32
  article-title: FGF23 protein expression in coronary arteries is associated with impaired kidney function
  publication-title: Nephrol. Dial. Transpl.
  doi: 10.1093/ndt/gft523
– volume: 101
  start-page: 119
  year: 2016
  ident: ref_36
  article-title: Klotho Prevents Translocation of NFkB
  publication-title: Vitam. Horm.
  doi: 10.1016/bs.vh.2016.02.005
– volume: 3
  start-page: 1245
  year: 2012
  ident: ref_42
  article-title: Symptomatic atherosclerosis is associated with an altered gut metagenome
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2266
– volume: 103
  start-page: 686
  year: 2023
  ident: ref_37
  article-title: The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2022.11.023
– volume: 8
  start-page: 42
  year: 2016
  ident: ref_43
  article-title: Impact of the gut microbiota on inflammation, obesity, and metabolic disease
  publication-title: Genome Med.
  doi: 10.1186/s13073-016-0303-2
– volume: 26
  start-page: 77
  year: 2008
  ident: ref_2
  article-title: Microvascular and Macrovascular Complications of Diabetes
  publication-title: Clin. Diabetes
  doi: 10.2337/diaclin.26.2.77
– volume: 31
  start-page: 594
  year: 2017
  ident: ref_9
  article-title: Serum klotho protein levels and their correlations with the progression of type 2 diabetes mellitus
  publication-title: J. Diabetes Complicat.
  doi: 10.1016/j.jdiacomp.2016.11.008
– volume: 30
  start-page: 126
  year: 2016
  ident: ref_18
  article-title: Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?
  publication-title: J. Diabetes Complicat.
  doi: 10.1016/j.jdiacomp.2015.09.013
– volume: 211
  start-page: 111789
  year: 2023
  ident: ref_22
  article-title: Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Klotho in coronary atherosclerotic disease
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2023.111789
– volume: 137
  start-page: 479
  year: 2012
  ident: ref_26
  article-title: Validation of an immunoassay for soluble Klotho protein: Decreased levels in diabetes and increased levels in chronic kidney disease
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/AJCPGPMAF7SFRBO4
– volume: 180
  start-page: 47
  year: 2013
  ident: ref_8
  article-title: Klotho and chronic kidney disease
  publication-title: Contrib. Nephrol.
  doi: 10.1159/000346778
– volume: 120
  start-page: e123
  year: 2012
  ident: ref_38
  article-title: Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy
  publication-title: Nephron Exp. Nephrol.
  doi: 10.1159/000342117
– volume: 167
  start-page: 156213
  year: 2023
  ident: ref_20
  article-title: Low serum Klotho reflects senile inflammation in middle-aged and elderly patients with coronary atherosclerosis
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2023.156213
– volume: 106
  start-page: 1357
  year: 2020
  ident: ref_3
  article-title: Diabetes and coronary artery disease: Not just a risk factor
  publication-title: Heart
  doi: 10.1136/heartjnl-2019-316243
– volume: 12
  start-page: 116
  year: 2013
  ident: ref_17
  article-title: Circulating alpha-klotho levels are not disturbed in patients with type 2 diabetes with and without macrovascular disease in the absence of nephropathy
  publication-title: Cardiovasc. Diabetol.
  doi: 10.1186/1475-2840-12-116
– volume: 81
  start-page: 539
  year: 2012
  ident: ref_10
  article-title: Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.423
– volume: 26
  start-page: 800
  year: 2011
  ident: ref_39
  article-title: Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
  publication-title: Nephrol. Dial. Transplant.
  doi: 10.1093/ndt/gfq537
– volume: 104
  start-page: 19796
  year: 2007
  ident: ref_40
  article-title: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0709805104
– volume: 10
  start-page: 472
  year: 2013
  ident: ref_4
  article-title: Cellular and molecular mechanisms of endothelial dysfunction in diabetes
  publication-title: Diabetes Vasc. Dis. Res.
  doi: 10.1177/1479164113500680
– ident: ref_12
  doi: 10.1371/journal.pone.0056695
– volume: 16
  start-page: 722
  year: 2012
  ident: ref_25
  article-title: Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
  publication-title: Clin. Exp. Nephrol.
  doi: 10.1007/s10157-012-0621-7
– volume: 276
  start-page: 83
  year: 2018
  ident: ref_15
  article-title: Circulating Klotho levels can predict long-term macrovascular outcomes in type 2 diabetic patients
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2018.07.006
– volume: 11
  start-page: 410
  year: 2012
  ident: ref_34
  article-title: Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2012.00796.x
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Snippet Circulating Klotho levels are significantly reduced in subjects with type 2 diabetes mellitus (T2DM) and in kidney disease patients. In this work, the...
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SubjectTerms Analysis
Atherosclerosis
Body mass index
Cardiovascular disease
Coronary heart disease
Coronary vessels
Development and progression
Diabetes
Diabetes therapy
Diabetics
Fibroblast growth factors
Kidney diseases
Kidneys
Longitudinal studies
Metabolic disorders
Mortality
Regression analysis
Signal transduction
Type 2 diabetes
Vein & artery diseases
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Title Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study
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https://pubmed.ncbi.nlm.nih.gov/PMC10488180
Volume 24
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