Controlled Human Infection and Rechallenge with Streptococcus pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults

• Published in: American journal of respiratory and critical care medicine Vol. 187; no. 8; pp. 855 - 864
• Main Authors: Ferreira, Daniela M., Neill, Daniel R., Bangert, Mathieu, Gritzfeld, Jenna F., Green, Nicola, Wright, Adam K. A., Pennington, Shaun H., Moreno, Laura Bricio, Moreno, Adriana T., Miyaji, Eliane N., Wright, Angela D., Collins, Andrea M., Goldblatt, David, Kadioglu, Aras, Gordon, Stephen B.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.04.2013
• Subjects: Administration, Intranasal; Adult; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Antibodies; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; Bacterial diseases; Bacterial Proteins - immunology; Biological and medical sciences; Carrier State - immunology; Experiments; Female; Human bacterial diseases; Humans; Immunoglobulin G - analysis; Immunoglobulin G - blood; Immunology; Infectious diseases; Intensive care medicine; Male; Medical sciences; Mice; Nasal Lavage Fluid - immunology; Nasal Lavage Fluid - microbiology; Nasal Mucosa - immunology; Pneumococcal Infections - immunology; Pneumococcal Infections - prevention & control; Pneumology; Pneumonia; Proteins; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus infections; Streptococcus pneumoniae - immunology; Vaccination - methods; Young Adult; United Kingdom > UK; Human; Intensive care; Respiratory disease; Immunity; Streptococcus pneumoniae; Infection; Prevention; Streptococcaceae; Efficiency; Streptococcal infection; Bacteriosis; Healthy carrier; Bacteria; Micrococcales; Adult; Models; Pneumococcal infection; human challenge models; Colonization; Resuscitation

The immunological and protective role of pneumococcal carriage in healthy adults is not known, but high rates of disease and death in the elderly are associated with low carriage prevalence. We employed an experimental human pneumococcal carriage model to investigate the immunizing effect of a singl...