Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity

• Published in: Molecular and cellular endocrinology Vol. 300; no. 1-2; pp. 37 - 42
• Main Authors: Poderoso, Cecilia, Maloberti, Paula, Duarte, Alejandra, Neuman, Isabel, Paz, Cristina, Maciel, Fabiana Cornejo, Podesta, Ernesto J.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 05.03.2009
• Subjects: Amino Acid Sequence; Animals; Cholesterol transport; Cyclic AMP-Dependent Protein Kinases - metabolism; Enzyme Activation; ERK1/2; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; MAP Kinase Kinase 1 - metabolism; MAP Kinase Kinase 2 - metabolism; MAP Kinase Signaling System - physiology; MEK1/2; Mitochondria - metabolism; Molecular Sequence Data; Phosphoproteins - metabolism; Phosphorylation; PKA; Protein phosphorylation; Sequence Alignment; Steroids - biosynthesis; Cholesterol transport; ERK1/2; Protein phosphorylation; MEK1/2; PKA

It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship between the MAPK cascade and StAR protein phosphorylation and function. We...