Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity

It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship between the MAPK cascade and StAR protein phosphorylation and function. We...

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Published inMolecular and cellular endocrinology Vol. 300; no. 1-2; pp. 37 - 42
Main Authors Poderoso, Cecilia, Maloberti, Paula, Duarte, Alejandra, Neuman, Isabel, Paz, Cristina, Maciel, Fabiana Cornejo, Podesta, Ernesto J.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 05.03.2009
Subjects
Amino Acid Sequence
Animals
Cholesterol transport
Cyclic AMP-Dependent Protein Kinases - metabolism
Enzyme Activation
ERK1/2
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
MAP Kinase Kinase 1 - metabolism
MAP Kinase Kinase 2 - metabolism
MAP Kinase Signaling System - physiology
MEK1/2
Mitochondria - metabolism
Molecular Sequence Data
Phosphoproteins - metabolism
Phosphorylation
PKA
Protein phosphorylation
Sequence Alignment
Steroids - biosynthesis
Cholesterol transport
ERK1/2
Protein phosphorylation
MEK1/2
PKA
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Abstract It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship between the MAPK cascade and StAR protein phosphorylation and function. We have demonstrated that (a) steroidogenesis in MA-10 Leydig cells depends on the specific of ERK1/2 activation at the mitochondria; (b) ERK1/2 phosphorylation is driven by mitochondrial PKA and constitutive MEK1/2 in this organelle; (c) active ERK1/2 interacts with StAR protein, leads to StAR protein phosphorylation at Ser232 only in the presence of cholesterol; (d) directed mutagenesis of Ser232 (S232A) inhibited in vitro StAR protein phosphorylation by ERK1; (e) transient transfection of MA-10 cells with StAR S232A cDNA markedly reduced the yield of progesterone production. We show that StAR protein is a substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric complex that regulates cholesterol transport.
AbstractList It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship between the MAPK cascade and StAR protein phosphorylation and function. We have demonstrated that (a) steroidogenesis in MA-10 Leydig cells depends on the specific of ERK1/2 activation at the mitochondria; (b) ERK1/2 phosphorylation is driven by mitochondrial PKA and constitutive MEK1/2 in this organelle; (c) active ERK1/2 interacts with StAR protein, leads to StAR protein phosphorylation at Ser232 only in the presence of cholesterol; (d) directed mutagenesis of Ser232 (S232A) inhibited in vitro StAR protein phosphorylation by ERK1; (e) transient transfection of MA-10 cells with StAR S232A cDNA markedly reduced the yield of progesterone production. We show that StAR protein is a substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric complex that regulates cholesterol transport.
It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship between the MAPK cascade and StAR protein phosphorylation and function. We have demonstrated that (a) steroidogenesis in MA-10 Leydig cells depends on the specific of ERK1/2 activation at the mitochondria; (b) ERK1/2 phosphorylation is driven by mitochondrial PKA and constitutive MEK1/2 in this organelle; (c) active ERK1/2 interacts with StAR protein, leads to StAR protein phosphorylation at Ser(232) only in the presence of cholesterol; (d) directed mutagenesis of Ser(232) (S232A) inhibited in vitro StAR protein phosphorylation by ERK1; (e) transient transfection of MA-10 cells with StAR S232A cDNA markedly reduced the yield of progesterone production. We show that StAR protein is a substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric complex that regulates cholesterol transport.
Author Neuman, Isabel
Maciel, Fabiana Cornejo
Paz, Cristina
Podesta, Ernesto J.
Poderoso, Cecilia
Maloberti, Paula
Duarte, Alejandra
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Issue 1-2
Keywords Cholesterol transport
ERK1/2
Protein phosphorylation
MEK1/2
PKA
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Snippet It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional...
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elsevier
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SubjectTerms Amino Acid Sequence
Animals
Cholesterol transport
Cyclic AMP-Dependent Protein Kinases - metabolism
Enzyme Activation
ERK1/2
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
MAP Kinase Kinase 1 - metabolism
MAP Kinase Kinase 2 - metabolism
MAP Kinase Signaling System - physiology
MEK1/2
Mitochondria - metabolism
Molecular Sequence Data
Phosphoproteins - metabolism
Phosphorylation
PKA
Protein phosphorylation
Sequence Alignment
Steroids - biosynthesis
Title Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity
URI https://dx.doi.org/10.1016/j.mce.2008.10.009
https://www.ncbi.nlm.nih.gov/pubmed/19007846
Volume 300
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