Effects of combined aging and heart failure on visceral sympathetic nerve and cardiovascular responses to progressive hyperthermia in F344 rats

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 299; no. 6; pp. R1555 - R1563
• Main Authors: Margiocco, M L, Borgarelli, M, Musch, T I, Hirai, D M, Hageman, K S, Fels, R J, Garcia, A A, Kenney, M J
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2010
• Subjects: Aging; Aging - physiology; Analysis of Variance; Animals; Blood Pressure - physiology; Body Temperature; Fever; Fever - physiopathology; Heart failure; Heart Failure - physiopathology; Heart Rate - physiology; Kidney - innervation; Rats; Rats, Inbred F344; Rodents; Spleen - innervation; Sympathetic Nervous System - physiopathology

Sympathetic nerve discharge (SND) responses to hyperthermia are attenuated in aged rats without heart failure (HF) and in young HF (Y(HF)) rats, demonstrating that individually aging and HF alter SND regulation. However, the combined effects of aging and HF on SND regulation to heat stress are unkno...