Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation

Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly...

Full description

Saved in:
Bibliographic Details
Published inMicrobiome Vol. 5; no. 1; p. 35
Main Authors Chua, Ling Ling, Rajasuriar, Reena, Azanan, Mohamad Shafiq, Abdullah, Noor Kamila, Tang, Mei San, Lee, Soo Ching, Woo, Yin Ling, Lim, Yvonne Ai Lian, Ariffin, Hany, Loke, P’ng
Format Journal Article
LanguageEnglish
Published England BioMed Central 20.03.2017
Subjects
Actinobacteria
Actinobacteria - genetics
Actinobacteria - isolation & purification
Adolescent
Adult
Anal Canal - microbiology
Bacteria - genetics
Bacteria - isolation & purification
Biodiversity
Biomarkers
C-Reactive Protein - analysis
Cancer therapies
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Chemotherapy
Childhood
Corynebacterium
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 2 - etiology
Disease
DNA
Dysbiosis
Feces
Genetic testing
Healthy Volunteers
HLA-DR Antigens
Homeostasis
Humans
Immune response
Immune system
Inflammation
Interleukin-6 - immunology
Leukemia
Lymphocyte Activation - immunology
Lymphocytes T
Metabolism
Metabolites
Microbiota
Obesity - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Surveillance
Survivors
Thermal cycling
Transplants & implants
Young Adult
Alpha diversity
Microbiota dysbiosis
Acute lymphoblastic leukemia
Adult survivors of childhood cancer
Immune activation
Inflammation
Microbiome
Online AccessGet full text

Cover

Abstract Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood. We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation. We demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.
AbstractList Background Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood. Results We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation. Conclusions We demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.
Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood.BACKGROUNDAdult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood.We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation.RESULTSWe compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation.We demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.CONCLUSIONSWe demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.
Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood. We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61). We identified an altered community with reduced microbial diversity in cancer survivors, who also exhibit signs of immune dysregulation including increased T cell activation and chronic inflammation. The bacterial community among cancer survivors was enriched for Actinobacteria (e.g. genus Corynebacterium) and depleted of Faecalibacterium, correlating with plasma concentrations of IL-6 and CRP and HLA-DR+CD4+ and HLA-DR+CD8+ T cells, which are established markers of inflammation and immune activation. We demonstrated a relationship between microbial dysbiosis and immune dysregulation in adult ALL survivors. These observations suggest that interventions that could restore microbial diversity may ameliorate chronic inflammation and, consequently, development of late effects of childhood cancer survivors.
ArticleNumber 35
Author Chua, Ling Ling
Abdullah, Noor Kamila
Loke, P’ng
Azanan, Mohamad Shafiq
Woo, Yin Ling
Rajasuriar, Reena
Ariffin, Hany
Lee, Soo Ching
Tang, Mei San
Lim, Yvonne Ai Lian
Author_xml – sequence: 1
  givenname: Ling Ling
  surname: Chua
  fullname: Chua, Ling Ling
– sequence: 2
  givenname: Reena
  surname: Rajasuriar
  fullname: Rajasuriar, Reena
– sequence: 3
  givenname: Mohamad Shafiq
  surname: Azanan
  fullname: Azanan, Mohamad Shafiq
– sequence: 4
  givenname: Noor Kamila
  surname: Abdullah
  fullname: Abdullah, Noor Kamila
– sequence: 5
  givenname: Mei San
  surname: Tang
  fullname: Tang, Mei San
– sequence: 6
  givenname: Soo Ching
  surname: Lee
  fullname: Lee, Soo Ching
– sequence: 7
  givenname: Yin Ling
  surname: Woo
  fullname: Woo, Yin Ling
– sequence: 8
  givenname: Yvonne Ai Lian
  surname: Lim
  fullname: Lim, Yvonne Ai Lian
– sequence: 9
  givenname: Hany
  surname: Ariffin
  fullname: Ariffin, Hany
– sequence: 10
  givenname: P’ng
  surname: Loke
  fullname: Loke, P’ng
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28320465$$D View this record in MEDLINE/PubMed
BookMark eNqNkk2LFDEQhoOsuOu6P8CLBLx4aU06n30RZPELFgTRc0gnaTtrOhmT9Mj8D3-wmZ1dGRcEc0mg3nqqUvU-BicxRQfAU4xeYiz5q0IR5rJDWHSoZ6jDD8BZj-jQ9RzLk6P3Kbgo5Rq1M2AqqHwETntJWpizM_Drs7OrcRYu3uQ0eh2g9VuXi6876CPUdg0VljVv_TblAtMEzeyDnVOyUJu1Ohh2y2ZOY9ClegODW7-7xWuo4zFUl5KM19WnWOBPX-cGN9np0kr7ZVmja7TqtzeKJ-DhpENxF7f3Ofj67u2Xyw_d1af3Hy_fXHWGclQ7jpEhllJL7CSY0YRNGgluiBFSEi4ERSMd9cS1pFQOnDgyUTwxLFlvDGLkHLw-cDfruDhrXKxZB7XJftF5p5L26u9I9LP6lraKETYMTDbAi1tATj9WV6pafDEuBB1dWovCchBEDIyR_5CKgXPCyZ76_J70Oq05tkk0laRE0rb4pnp23Pyfru922wTiIGg7KCW7SRlfb-bb_uKDwkjtjaQORlLNSGpvJIVbJr6XeQf_d85viT_Nzg
CitedBy_id crossref_primary_10_2174_1566524021666210302144720
crossref_primary_10_1016_j_ejmech_2020_112582
crossref_primary_10_1016_j_leukres_2023_107017
crossref_primary_10_3390_v11070656
crossref_primary_10_3390_children12020166
crossref_primary_10_1016_j_tim_2017_10_009
crossref_primary_10_1186_s12885_020_6654_5
crossref_primary_10_1080_08880018_2020_1759740
crossref_primary_10_3389_fcimb_2020_558799
crossref_primary_10_3389_fcimb_2024_1412035
crossref_primary_10_3390_cancers17010154
crossref_primary_10_3389_fmicb_2022_1045497
crossref_primary_10_3390_microorganisms11071775
crossref_primary_10_1016_j_exphem_2024_104211
crossref_primary_10_1038_s41392_023_01619_w
crossref_primary_10_1177_15330338221149799
crossref_primary_10_3390_cancers13205064
crossref_primary_10_1016_j_neulet_2021_135720
crossref_primary_10_1080_08880018_2022_2049937
crossref_primary_10_1099_jmm_0_000568
crossref_primary_10_1016_j_bbmt_2019_07_006
crossref_primary_10_1111_jhn_13273
crossref_primary_10_1007_s00248_019_01448_x
crossref_primary_10_1080_01635581_2023_2267779
crossref_primary_10_1097_MPH_0000000000002586
crossref_primary_10_1038_s41598_018_32585_x
crossref_primary_10_1038_s41598_020_78493_x
crossref_primary_10_1016_j_intimp_2018_11_020
crossref_primary_10_1136_gutjnl_2018_317503
crossref_primary_10_1182_hem_V21_5_202452
crossref_primary_10_1111_jdv_18125
crossref_primary_10_1016_j_ebiom_2019_03_070
crossref_primary_10_1002_mc_23151
crossref_primary_10_3390_ijms25073928
crossref_primary_10_1182_bloodadvances_2021005129
crossref_primary_10_3390_microorganisms10040713
crossref_primary_10_1016_j_critrevonc_2021_103289
crossref_primary_10_3389_fragi_2021_708788
crossref_primary_10_1007_s00277_023_05480_3
crossref_primary_10_3389_fimmu_2017_01032
crossref_primary_10_1002_cncr_30857
crossref_primary_10_1186_s12941_024_00717_z
crossref_primary_10_1002_cncr_33400
crossref_primary_10_1007_s00520_020_05579_7
crossref_primary_10_1089_ars_2020_8102
crossref_primary_10_1002_cncr_33030
crossref_primary_10_1155_2019_8941471
crossref_primary_10_1177_11795549211024197
crossref_primary_10_3389_fmicb_2023_1185787
crossref_primary_10_1080_08880018_2020_1793850
crossref_primary_10_1038_s41577_023_00951_0
crossref_primary_10_3390_jcm9124068
crossref_primary_10_1038_s41368_024_00282_3
crossref_primary_10_3390_ijms24021732
crossref_primary_10_1002_pbc_29308
crossref_primary_10_1016_S2352_4642_19_30407_9
crossref_primary_10_3390_cancers13194947
Cites_doi 10.1086/599346
10.1038/nature11550
10.1097/00006454-199704000-00003
10.1053/j.gastro.2015.05.008
10.1093/jac/dkp081
10.1111/j.1462-2920.2005.00763.x
10.1016/j.immuni.2013.08.003
10.1016/j.gendis.2014.08.001
10.1002/art.38892
10.1126/science.aaf3229
10.1667/RR1903.1
10.1038/nature10213
10.1038/nmeth.f.303
10.1038/nmicrobiol.2016.93
10.1038/nbt.2676
10.1182/blood-2009-12-257451
10.1016/j.cell.2012.01.035
10.1097/QAD.0000000000000154
10.1016/j.ejca.2014.01.014
10.1038/ncomms12015
10.1002/eji.201646356
10.1038/ni.2422
10.1016/j.phrs.2012.10.005
10.1073/pnas.0804812105
10.3322/caac.21235
10.4161/gmic.19897
10.1186/s13073-016-0262-7
10.1016/j.mib.2013.06.003
10.1038/nm.3145
10.1038/srep24072
10.1016/j.pt.2015.10.001
10.1007/s00281-013-0399-z
10.1111/cea.12253
10.3390/nu8040202
10.1136/gutjnl-2012-302504
10.1200/JCO.2013.51.1055
10.1200/JCO.2008.21.1425
10.1016/j.cmet.2014.07.006
10.1001/jama.2013.6296
10.1111/j.1753-4887.2012.00498.x
10.3389/fimmu.2015.00639
10.1038/nature18848
10.1053/j.gastro.2011.01.049
10.1136/gutjnl-2012-303249
10.1073/pnas.1000080107
10.1200/JCO.2006.07.2884
10.1038/ismej.2008.37
10.1136/gutjnl-2013-304833
10.1200/JCO.2013.52.2268
10.1002/ibd.20903
10.1111/apt.13302
10.1016/j.ijrobp.2012.07.008
10.1128/AAC.40.5.1108
10.1186/s13073-016-0294-z
10.1093/toxsci/kfw150
10.1038/ncomms2266
10.1016/j.febslet.2014.03.019
10.1371/journal.pone.0101344
10.1186/gb-2011-12-6-r60
10.1056/NEJMsa060185
10.1126/scitranslmed.3006438
10.1371/journal.pone.0160169
10.1038/nmicrobiol.2016.228
10.1186/s40168-014-0050-9
10.1073/pnas.0706625104
10.1002/hep.27489
10.1038/nri2515
10.1126/scitranslmed.3000632
10.1128/CVI.00214-06
10.1681/ASN.2015111285
10.1016/j.immuni.2009.08.020
10.1002/cncr.26337
10.1073/pnas.1000082107
10.1038/ismej.2010.92
ContentType Journal Article
Copyright Copyright BioMed Central 2017
The Author(s). 2017
Copyright_xml – notice: Copyright BioMed Central 2017
– notice: The Author(s). 2017
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
7SN
C1K
5PM
DOI 10.1186/s40168-017-0250-1
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Database
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection (UHCL Subscription)
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (UHCL Subscription)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
Ecology Abstracts
Environmental Sciences and Pollution Management
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
Ecology Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList Ecology Abstracts
MEDLINE - Academic
MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2049-2618
ExternalDocumentID PMC5359958
28320465
10_1186_s40168_017_0250_1
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: RP029-14HTM
– fundername: ;
  grantid: UM.C/HIR/MOHE/MED/12; UM.C/625/HIR/MOE/MED/23
GroupedDBID 0R~
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAHBH
AAJSJ
AASML
AAYXX
ABUWG
ACGFS
ADBBV
ADRAZ
ADUKV
AENEX
AFKRA
AFPKN
AHBYD
AHSBF
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AOIJS
ASPBG
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
DIK
EBLON
EBS
EJD
FYUFA
GROUPED_DOAJ
GX1
H13
HCIFZ
HMCUK
HYE
IAG
IAO
IEP
IHR
INH
INR
ISR
ITC
KQ8
LK8
M1P
M48
M7P
M~E
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
ROL
RPM
RSV
SOJ
UKHRP
-A0
3V.
ACRMQ
ADINQ
C24
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
7SN
C1K
5PM
ID FETCH-LOGICAL-c460t-610c3d44d3df75ca35fa076c3c788367740b4baf6a8448963e3f41f51852cc053
IEDL.DBID 7X7
ISSN 2049-2618
IngestDate Thu Aug 21 18:21:28 EDT 2025
Mon Jul 21 09:22:52 EDT 2025
Thu Jul 10 18:04:09 EDT 2025
Fri Jul 25 12:05:08 EDT 2025
Thu Jan 02 23:10:26 EST 2025
Tue Jul 01 04:16:34 EDT 2025
Thu Apr 24 23:09:59 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Alpha diversity
Microbiota dysbiosis
Acute lymphoblastic leukemia
Adult survivors of childhood cancer
Immune activation
Inflammation
Microbiome
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c460t-610c3d44d3df75ca35fa076c3c788367740b4baf6a8448963e3f41f51852cc053
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/1884384168?pq-origsite=%requestingapplication%
PMID 28320465
PQID 1884384168
PQPubID 2040205
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5359958
proquest_miscellaneous_1897379553
proquest_miscellaneous_1879663638
proquest_journals_1884384168
pubmed_primary_28320465
crossref_citationtrail_10_1186_s40168_017_0250_1
crossref_primary_10_1186_s40168_017_0250_1
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-03-20
PublicationDateYYYYMMDD 2017-03-20
PublicationDate_xml – month: 03
  year: 2017
  text: 2017-03-20
  day: 20
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Microbiome
PublicationTitleAlternate Microbiome
PublicationYear 2017
Publisher BioMed Central
Publisher_xml – name: BioMed Central
References K Machiels (250_CR50) 2014; 63
NM Blijlevens (250_CR12) 2009; 63
S Miquel (250_CR49) 2013; 16
H Sokol (250_CR51) 2009; 15
MT Khan (250_CR71) 2014; 20
MG Langille (250_CR24) 2014; 2
MG Langille (250_CR41) 2013; 31
J Dicksved (250_CR60) 2008; 2
ME Sanders (250_CR73) 2013; 62
JL Round (250_CR28) 2009; 9
RA Koeth (250_CR22) 2013; 19
MJ Vliet van (250_CR13) 2009; 49
E Montassier (250_CR14) 2015; 42
D Favre (250_CR69) 2010; 2
D Kelly (250_CR18) 2012; 70
MS Azanan (250_CR35) 2016; 46
A Langdon (250_CR57) 2016; 8
R Charnas (250_CR17) 1997; 16
MM Hudson (250_CR3) 2013; 309
CE DeSantis (250_CR1) 2014; 64
KK Ness (250_CR11) 2012; 118
DC Bowers (250_CR7) 2006; 24
250_CR32
250_CR34
KA Cao Le (250_CR43) 2016; 11
AS Holmqvist (250_CR6) 2014; 50
250_CR39
A Woting (250_CR48) 2016; 8
GT Armstrong (250_CR4) 2014; 32
N Segata (250_CR42) 2011; 12
JC Clemente (250_CR61) 2012; 148
HJ Flint (250_CR67) 2012; 3
P Loke (250_CR70) 2010; 115
WB Dyer (250_CR44) 2007; 14
FH Karlsson (250_CR23) 2012; 3
JG Caporaso (250_CR38) 2011; 108
RS Goldszmid (250_CR20) 2012; 13
S Kim (250_CR45) 2015; 22
R Goldsby (250_CR15) 2011; 140
C Lay (250_CR66) 2005; 7
J Sun (250_CR46) 2014; 1
HE Jakobsson (250_CR62) 2014; 63
SW Olesen (250_CR27) 2016; 1
GT Armstrong (250_CR5) 2009; 27
KC Oeffinger (250_CR2) 2006; 355
S Omenetti (250_CR52) 2015; 6
AL Kau (250_CR19) 2011; 474
G Yu (250_CR36) 2014; 28
P Loke (250_CR76) 2015; 31
GT Armstrong (250_CR10) 2010; 174
E Biagi (250_CR25) 2013; 69
HM Roager (250_CR65) 2016; 1
MM Kosiewicz (250_CR31) 2014; 588
JU Scher (250_CR47) 2015; 67
TR Abrahamsson (250_CR63) 2014; 44
CA Lozupone (250_CR58) 2012; 489
YK Lee (250_CR30) 2011; 108
T Zelante (250_CR72) 2013; 39
P Lopez (250_CR29) 2016; 6
K Honda (250_CR68) 2016; 535
P Chen (250_CR33) 2015; 61
DN Frank (250_CR54) 2007; 104
IW Dijk van (250_CR9) 2013; 85
KK Ness (250_CR8) 2013; 31
JG Caporaso (250_CR40) 2010; 7
V Gaboriau-Routhiau (250_CR53) 2009; 31
H Sokol (250_CR55) 2008; 105
MA Jackson (250_CR26) 2016; 8
A Cometta (250_CR16) 1996; 40
S Jangi (250_CR59) 2016; 7
A Giongo (250_CR64) 2011; 5
CR Kelly (250_CR74) 2015; 149
S Fukuda (250_CR21) 2014; 36
I Vujkovic-Cvijin (250_CR56) 2013; 5
D Ramanan (250_CR75) 2016; 352
AE Budding (250_CR37) 2014; 9
21128808 - Radiat Res. 2010 Dec;174(6):840-50
26147207 - Aliment Pharmacol Ther. 2015 Sep;42(5):515-28
9109134 - Pediatr Infect Dis J. 1997 Apr;16(4):346-53
22424233 - Cell. 2012 Mar 16;148(6):1258-70
27080105 - Science. 2016 Apr 29;352(6285):608-12
23212374 - Nat Commun. 2012;3:1245
19235886 - Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
20613793 - ISME J. 2011 Jan;5(1):82-91
20484731 - Sci Transl Med. 2010 May 19;2(32):32ra36
23973224 - Immunity. 2013 Aug 22;39(2):372-85
23474420 - Gut. 2013 May;62(5):787-96
25176147 - Cell Metab. 2014 Nov 4;20(5):753-60
25020051 - PLoS One. 2014 Jul 14;9(7):e101344
18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
22972295 - Nature. 2012 Sep 13;489(7415):220-30
8723449 - Antimicrob Agents Chemother. 1996 May;40(5):1108-15
22861803 - Nutr Rev. 2012 Aug;70 Suppl 1:S18-30
19343057 - Nat Rev Immunol. 2009 May;9(5):313-23
17035650 - N Engl J Med. 2006 Oct 12;355(15):1572-82
21766297 - Cancer. 2012 Feb 1;118(3):828-38
18401439 - ISME J. 2008 Jul;2(7):716-27
19332714 - J Clin Oncol. 2009 May 10;27(14):2328-38
23831042 - Curr Opin Microbiol. 2013 Jun;16(3):255-61
23926244 - Gut. 2014 Apr;63(4):559-66
20534432 - Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22
27044888 - Sci Rep. 2016 Apr 05;6:24072
24330256 - Clin Exp Allergy. 2014 Jun;44(6):842-50
23563705 - Nat Med. 2013 May;19(5):576-85
24021287 - Gut. 2014 Aug;63(8):1275-83
27513472 - PLoS One. 2016 Aug 11;11(8):e0160169
27151924 - J Am Soc Nephrol. 2017 Jan;28(1):76-83
24335481 - AIDS. 2014 Mar 13;28(5):753-60
17050740 - Clin Vaccine Immunol. 2007 Jan;14(1):52-9
27503388 - Toxicol Sci. 2016 Nov;154(1):140-152
25319745 - Arthritis Rheumatol. 2015 Jan;67(1):128-39
27886190 - Nat Microbiol. 2016 Nov 25;1:16228
25982290 - Gastroenterology. 2015 Jul;149(1):223-37
20660719 - Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22
24196453 - Semin Immunopathol. 2014 Jan;36(1):103-14
26604162 - Trends Parasitol. 2015 Nov;31(11):534-5
15946290 - Environ Microbiol. 2005 Jul;7(7):933-46
24890451 - CA Cancer J Clin. 2014 Jul-Aug;64(4):252-71
27383982 - Nature. 2016 Jul 06;535(7610):75-84
23843452 - Sci Transl Med. 2013 Jul 10;5(193):193ra91
26822992 - Genome Med. 2016 Jan 29;8(1):8
20383131 - Nat Methods. 2010 May;7(5):335-6
21702898 - Genome Biol. 2011 Jun 24;12(6):R60
23975157 - Nat Biotechnol. 2013 Sep;31(9):814-21
24507548 - Eur J Cancer. 2014 Apr;50(6):1169-75
17699621 - Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5
27129782 - Eur J Immunol. 2016 Jul;46(7):1715-26
27058556 - Nutrients. 2016 Apr 06;8(4):202
21677749 - Nature. 2011 Jun 15;474(7351):327-36
20160163 - Blood. 2010 Apr 15;115(15):e20-32
23757085 - JAMA. 2013 Jun 12;309(22):2371-81
19372181 - J Antimicrob Chemother. 2009 May;63 Suppl 1:i36-40
22990891 - Nat Immunol. 2012 Oct;13(10):932-8
19514856 - Clin Infect Dis. 2009 Jul 15;49(2):262-70
25642449 - Genes Dis. 2014 Dec;1(2):132-139
26734006 - Front Immunol. 2015 Dec 17;6:639
27562254 - Nat Microbiol. 2016 Jun 27;1(9):16093
26688802 - Commun Stat Appl Methods. 2015 Nov;22(6):665-674
27074706 - Genome Med. 2016 Apr 13;8(1):39
25251280 - Hepatology. 2015 Mar;61(3):883-94
25520805 - Microbiome. 2014 Dec 05;2(1):50
19833089 - Immunity. 2009 Oct 16;31(4):677-89
17088567 - J Clin Oncol. 2006 Nov 20;24(33):5277-82
24638000 - J Clin Oncol. 2014 Apr 20;32(12):1218-27
22572875 - Gut Microbes. 2012 Jul-Aug;3(4):289-306
23079287 - Pharmacol Res. 2013 Mar;69(1):11-20
27352007 - Nat Commun. 2016 Jun 28;7:12015
24248696 - J Clin Oncol. 2013 Dec 20;31(36):4496-503
24681103 - FEBS Lett. 2014 Nov 17;588(22):4195-206
21315721 - Gastroenterology. 2011 May;140(5):1464-71.e1
22954771 - Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):768-75
References_xml – volume: 49
  start-page: 262
  issue: 2
  year: 2009
  ident: 250_CR13
  publication-title: Clin Infect Dis
  doi: 10.1086/599346
– volume: 489
  start-page: 220
  issue: 7415
  year: 2012
  ident: 250_CR58
  publication-title: Nature
  doi: 10.1038/nature11550
– volume: 16
  start-page: 346
  issue: 4
  year: 1997
  ident: 250_CR17
  publication-title: Pediatr Infect Dis J
  doi: 10.1097/00006454-199704000-00003
– volume: 149
  start-page: 223
  issue: 1
  year: 2015
  ident: 250_CR74
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.05.008
– volume: 63
  start-page: i36
  issue: Suppl 1
  year: 2009
  ident: 250_CR12
  publication-title: J Antimicrob Chemother
  doi: 10.1093/jac/dkp081
– volume: 7
  start-page: 933
  issue: 7
  year: 2005
  ident: 250_CR66
  publication-title: Environ Microbiol
  doi: 10.1111/j.1462-2920.2005.00763.x
– volume: 39
  start-page: 372
  issue: 2
  year: 2013
  ident: 250_CR72
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.003
– volume: 1
  start-page: 132
  issue: 2
  year: 2014
  ident: 250_CR46
  publication-title: Genes Dis
  doi: 10.1016/j.gendis.2014.08.001
– volume: 67
  start-page: 128
  issue: 1
  year: 2015
  ident: 250_CR47
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.38892
– volume: 352
  start-page: 608
  issue: 6285
  year: 2016
  ident: 250_CR75
  publication-title: Science
  doi: 10.1126/science.aaf3229
– volume: 174
  start-page: 840
  issue: 6
  year: 2010
  ident: 250_CR10
  publication-title: Radiat Res
  doi: 10.1667/RR1903.1
– volume: 474
  start-page: 327
  issue: 7351
  year: 2011
  ident: 250_CR19
  publication-title: Nature
  doi: 10.1038/nature10213
– volume: 7
  start-page: 335
  issue: 5
  year: 2010
  ident: 250_CR40
  publication-title: Nat Methods
  doi: 10.1038/nmeth.f.303
– volume: 1
  start-page: 16093
  issue: 9
  year: 2016
  ident: 250_CR65
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.93
– volume: 31
  start-page: 814
  issue: 9
  year: 2013
  ident: 250_CR41
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.2676
– volume: 115
  start-page: e20
  issue: 15
  year: 2010
  ident: 250_CR70
  publication-title: Blood
  doi: 10.1182/blood-2009-12-257451
– volume: 148
  start-page: 1258
  issue: 6
  year: 2012
  ident: 250_CR61
  publication-title: Cell
  doi: 10.1016/j.cell.2012.01.035
– volume: 28
  start-page: 753
  issue: 5
  year: 2014
  ident: 250_CR36
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000154
– volume: 50
  start-page: 1169
  issue: 6
  year: 2014
  ident: 250_CR6
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2014.01.014
– volume: 7
  start-page: 12015
  year: 2016
  ident: 250_CR59
  publication-title: Nat Commun
  doi: 10.1038/ncomms12015
– ident: 250_CR39
– volume: 46
  start-page: 1715
  issue: 7
  year: 2016
  ident: 250_CR35
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201646356
– volume: 13
  start-page: 932
  issue: 10
  year: 2012
  ident: 250_CR20
  publication-title: Nat Immunol
  doi: 10.1038/ni.2422
– volume: 69
  start-page: 11
  issue: 1
  year: 2013
  ident: 250_CR25
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2012.10.005
– volume: 22
  start-page: 665
  issue: 6
  year: 2015
  ident: 250_CR45
  publication-title: Commun Stat Appl Methods
– volume: 105
  start-page: 16731
  issue: 43
  year: 2008
  ident: 250_CR55
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0804812105
– volume: 64
  start-page: 252
  issue: 4
  year: 2014
  ident: 250_CR1
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21235
– volume: 3
  start-page: 289
  issue: 4
  year: 2012
  ident: 250_CR67
  publication-title: Gut Microbes
  doi: 10.4161/gmic.19897
– volume: 8
  start-page: 8
  issue: 1
  year: 2016
  ident: 250_CR26
  publication-title: Genome Med
  doi: 10.1186/s13073-016-0262-7
– volume: 16
  start-page: 255
  issue: 3
  year: 2013
  ident: 250_CR49
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2013.06.003
– volume: 19
  start-page: 576
  issue: 5
  year: 2013
  ident: 250_CR22
  publication-title: Nat Med
  doi: 10.1038/nm.3145
– volume: 6
  start-page: 24072
  year: 2016
  ident: 250_CR29
  publication-title: Sci Rep
  doi: 10.1038/srep24072
– volume: 31
  start-page: 534
  issue: 11
  year: 2015
  ident: 250_CR76
  publication-title: Trends Parasitol
  doi: 10.1016/j.pt.2015.10.001
– volume: 36
  start-page: 103
  issue: 1
  year: 2014
  ident: 250_CR21
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-013-0399-z
– volume: 44
  start-page: 842
  issue: 6
  year: 2014
  ident: 250_CR63
  publication-title: Clin Exp Allergy
  doi: 10.1111/cea.12253
– volume: 8
  start-page: 202
  issue: 4
  year: 2016
  ident: 250_CR48
  publication-title: Nutrients
  doi: 10.3390/nu8040202
– volume: 62
  start-page: 787
  issue: 5
  year: 2013
  ident: 250_CR73
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-302504
– volume: 32
  start-page: 1218
  issue: 12
  year: 2014
  ident: 250_CR4
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2013.51.1055
– volume: 27
  start-page: 2328
  issue: 14
  year: 2009
  ident: 250_CR5
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2008.21.1425
– volume: 20
  start-page: 753
  issue: 5
  year: 2014
  ident: 250_CR71
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2014.07.006
– volume: 309
  start-page: 2371
  issue: 22
  year: 2013
  ident: 250_CR3
  publication-title: JAMA
  doi: 10.1001/jama.2013.6296
– volume: 70
  start-page: S18
  issue: Suppl 1
  year: 2012
  ident: 250_CR18
  publication-title: Nutr Rev
  doi: 10.1111/j.1753-4887.2012.00498.x
– volume: 6
  start-page: 639
  year: 2015
  ident: 250_CR52
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2015.00639
– volume: 535
  start-page: 75
  issue: 7610
  year: 2016
  ident: 250_CR68
  publication-title: Nature
  doi: 10.1038/nature18848
– volume: 140
  start-page: 1464
  issue: 5
  year: 2011
  ident: 250_CR15
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.01.049
– volume: 63
  start-page: 559
  issue: 4
  year: 2014
  ident: 250_CR62
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-303249
– volume: 108
  start-page: 4516
  issue: Suppl 1
  year: 2011
  ident: 250_CR38
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1000080107
– volume: 24
  start-page: 5277
  issue: 33
  year: 2006
  ident: 250_CR7
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2006.07.2884
– volume: 2
  start-page: 716
  issue: 7
  year: 2008
  ident: 250_CR60
  publication-title: ISME J
  doi: 10.1038/ismej.2008.37
– volume: 63
  start-page: 1275
  issue: 8
  year: 2014
  ident: 250_CR50
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-304833
– volume: 31
  start-page: 4496
  issue: 36
  year: 2013
  ident: 250_CR8
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2013.52.2268
– volume: 15
  start-page: 1183
  issue: 8
  year: 2009
  ident: 250_CR51
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.20903
– volume: 42
  start-page: 515
  issue: 5
  year: 2015
  ident: 250_CR14
  publication-title: Aliment Pharmacol Ther
  doi: 10.1111/apt.13302
– volume: 85
  start-page: 768
  issue: 3
  year: 2013
  ident: 250_CR9
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/j.ijrobp.2012.07.008
– volume: 40
  start-page: 1108
  issue: 5
  year: 1996
  ident: 250_CR16
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.40.5.1108
– volume: 8
  start-page: 39
  issue: 1
  year: 2016
  ident: 250_CR57
  publication-title: Genome Med
  doi: 10.1186/s13073-016-0294-z
– ident: 250_CR32
  doi: 10.1093/toxsci/kfw150
– volume: 3
  start-page: 1245
  year: 2012
  ident: 250_CR23
  publication-title: Nat Commun
  doi: 10.1038/ncomms2266
– volume: 588
  start-page: 4195
  issue: 22
  year: 2014
  ident: 250_CR31
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2014.03.019
– volume: 9
  start-page: e101344
  issue: 7
  year: 2014
  ident: 250_CR37
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0101344
– volume: 12
  start-page: R60
  issue: 6
  year: 2011
  ident: 250_CR42
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-6-r60
– volume: 355
  start-page: 1572
  issue: 15
  year: 2006
  ident: 250_CR2
  publication-title: N Engl J Med
  doi: 10.1056/NEJMsa060185
– volume: 5
  start-page: 193ra91
  issue: 193
  year: 2013
  ident: 250_CR56
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3006438
– volume: 11
  start-page: e0160169
  issue: 8
  year: 2016
  ident: 250_CR43
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0160169
– volume: 1
  start-page: 1
  year: 2016
  ident: 250_CR27
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2016.228
– volume: 2
  start-page: 50
  issue: 1
  year: 2014
  ident: 250_CR24
  publication-title: Microbiome
  doi: 10.1186/s40168-014-0050-9
– volume: 104
  start-page: 13780
  issue: 34
  year: 2007
  ident: 250_CR54
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0706625104
– volume: 61
  start-page: 883
  issue: 3
  year: 2015
  ident: 250_CR33
  publication-title: Hepatology
  doi: 10.1002/hep.27489
– volume: 9
  start-page: 313
  issue: 5
  year: 2009
  ident: 250_CR28
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2515
– volume: 2
  start-page: 32ra6
  issue: 32
  year: 2010
  ident: 250_CR69
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3000632
– volume: 14
  start-page: 52
  issue: 1
  year: 2007
  ident: 250_CR44
  publication-title: Clin Vaccine Immunol
  doi: 10.1128/CVI.00214-06
– ident: 250_CR34
  doi: 10.1681/ASN.2015111285
– volume: 31
  start-page: 677
  issue: 4
  year: 2009
  ident: 250_CR53
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.08.020
– volume: 118
  start-page: 828
  issue: 3
  year: 2012
  ident: 250_CR11
  publication-title: Cancer
  doi: 10.1002/cncr.26337
– volume: 108
  start-page: 4615
  issue: Suppl 1
  year: 2011
  ident: 250_CR30
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1000082107
– volume: 5
  start-page: 82
  issue: 1
  year: 2011
  ident: 250_CR64
  publication-title: ISME J
  doi: 10.1038/ismej.2010.92
– reference: 26147207 - Aliment Pharmacol Ther. 2015 Sep;42(5):515-28
– reference: 27562254 - Nat Microbiol. 2016 Jun 27;1(9):16093
– reference: 17699621 - Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13780-5
– reference: 17050740 - Clin Vaccine Immunol. 2007 Jan;14(1):52-9
– reference: 22954771 - Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):768-75
– reference: 24890451 - CA Cancer J Clin. 2014 Jul-Aug;64(4):252-71
– reference: 27151924 - J Am Soc Nephrol. 2017 Jan;28(1):76-83
– reference: 20534432 - Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22
– reference: 27058556 - Nutrients. 2016 Apr 06;8(4):202
– reference: 23563705 - Nat Med. 2013 May;19(5):576-85
– reference: 27080105 - Science. 2016 Apr 29;352(6285):608-12
– reference: 19235886 - Inflamm Bowel Dis. 2009 Aug;15(8):1183-9
– reference: 22990891 - Nat Immunol. 2012 Oct;13(10):932-8
– reference: 21677749 - Nature. 2011 Jun 15;474(7351):327-36
– reference: 24330256 - Clin Exp Allergy. 2014 Jun;44(6):842-50
– reference: 20484731 - Sci Transl Med. 2010 May 19;2(32):32ra36
– reference: 23757085 - JAMA. 2013 Jun 12;309(22):2371-81
– reference: 23831042 - Curr Opin Microbiol. 2013 Jun;16(3):255-61
– reference: 21128808 - Radiat Res. 2010 Dec;174(6):840-50
– reference: 20613793 - ISME J. 2011 Jan;5(1):82-91
– reference: 24335481 - AIDS. 2014 Mar 13;28(5):753-60
– reference: 19372181 - J Antimicrob Chemother. 2009 May;63 Suppl 1:i36-40
– reference: 27074706 - Genome Med. 2016 Apr 13;8(1):39
– reference: 21702898 - Genome Biol. 2011 Jun 24;12(6):R60
– reference: 22424233 - Cell. 2012 Mar 16;148(6):1258-70
– reference: 25176147 - Cell Metab. 2014 Nov 4;20(5):753-60
– reference: 23079287 - Pharmacol Res. 2013 Mar;69(1):11-20
– reference: 24021287 - Gut. 2014 Aug;63(8):1275-83
– reference: 27129782 - Eur J Immunol. 2016 Jul;46(7):1715-26
– reference: 27886190 - Nat Microbiol. 2016 Nov 25;1:16228
– reference: 8723449 - Antimicrob Agents Chemother. 1996 May;40(5):1108-15
– reference: 17035650 - N Engl J Med. 2006 Oct 12;355(15):1572-82
– reference: 24681103 - FEBS Lett. 2014 Nov 17;588(22):4195-206
– reference: 23843452 - Sci Transl Med. 2013 Jul 10;5(193):193ra91
– reference: 22972295 - Nature. 2012 Sep 13;489(7415):220-30
– reference: 23973224 - Immunity. 2013 Aug 22;39(2):372-85
– reference: 26604162 - Trends Parasitol. 2015 Nov;31(11):534-5
– reference: 23474420 - Gut. 2013 May;62(5):787-96
– reference: 20383131 - Nat Methods. 2010 May;7(5):335-6
– reference: 21766297 - Cancer. 2012 Feb 1;118(3):828-38
– reference: 21315721 - Gastroenterology. 2011 May;140(5):1464-71.e1
– reference: 15946290 - Environ Microbiol. 2005 Jul;7(7):933-46
– reference: 23212374 - Nat Commun. 2012;3:1245
– reference: 25642449 - Genes Dis. 2014 Dec;1(2):132-139
– reference: 23926244 - Gut. 2014 Apr;63(4):559-66
– reference: 24248696 - J Clin Oncol. 2013 Dec 20;31(36):4496-503
– reference: 25251280 - Hepatology. 2015 Mar;61(3):883-94
– reference: 26822992 - Genome Med. 2016 Jan 29;8(1):8
– reference: 19833089 - Immunity. 2009 Oct 16;31(4):677-89
– reference: 24638000 - J Clin Oncol. 2014 Apr 20;32(12):1218-27
– reference: 25520805 - Microbiome. 2014 Dec 05;2(1):50
– reference: 17088567 - J Clin Oncol. 2006 Nov 20;24(33):5277-82
– reference: 19332714 - J Clin Oncol. 2009 May 10;27(14):2328-38
– reference: 25319745 - Arthritis Rheumatol. 2015 Jan;67(1):128-39
– reference: 18936492 - Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
– reference: 24196453 - Semin Immunopathol. 2014 Jan;36(1):103-14
– reference: 27383982 - Nature. 2016 Jul 06;535(7610):75-84
– reference: 22861803 - Nutr Rev. 2012 Aug;70 Suppl 1:S18-30
– reference: 24507548 - Eur J Cancer. 2014 Apr;50(6):1169-75
– reference: 27044888 - Sci Rep. 2016 Apr 05;6:24072
– reference: 27513472 - PLoS One. 2016 Aug 11;11(8):e0160169
– reference: 22572875 - Gut Microbes. 2012 Jul-Aug;3(4):289-306
– reference: 20660719 - Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22
– reference: 27503388 - Toxicol Sci. 2016 Nov;154(1):140-152
– reference: 27352007 - Nat Commun. 2016 Jun 28;7:12015
– reference: 20160163 - Blood. 2010 Apr 15;115(15):e20-32
– reference: 9109134 - Pediatr Infect Dis J. 1997 Apr;16(4):346-53
– reference: 19514856 - Clin Infect Dis. 2009 Jul 15;49(2):262-70
– reference: 25982290 - Gastroenterology. 2015 Jul;149(1):223-37
– reference: 26734006 - Front Immunol. 2015 Dec 17;6:639
– reference: 19343057 - Nat Rev Immunol. 2009 May;9(5):313-23
– reference: 26688802 - Commun Stat Appl Methods. 2015 Nov;22(6):665-674
– reference: 18401439 - ISME J. 2008 Jul;2(7):716-27
– reference: 25020051 - PLoS One. 2014 Jul 14;9(7):e101344
– reference: 23975157 - Nat Biotechnol. 2013 Sep;31(9):814-21
SSID ssj0000914748
Score 2.3545902
Snippet Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy....
Background Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 35
SubjectTerms Actinobacteria
Actinobacteria - genetics
Actinobacteria - isolation & purification
Adolescent
Adult
Anal Canal - microbiology
Bacteria - genetics
Bacteria - isolation & purification
Biodiversity
Biomarkers
C-Reactive Protein - analysis
Cancer therapies
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Chemotherapy
Childhood
Corynebacterium
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 2 - etiology
Disease
DNA
Dysbiosis
Feces
Genetic testing
Healthy Volunteers
HLA-DR Antigens
Homeostasis
Humans
Immune response
Immune system
Inflammation
Interleukin-6 - immunology
Leukemia
Lymphocyte Activation - immunology
Lymphocytes T
Metabolism
Metabolites
Microbiota
Obesity - etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Surveillance
Survivors
Thermal cycling
Transplants & implants
Young Adult
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LixQxEC6WFcGLrO_WVSJ4Elq7J885iIi4LMJ6EAf21iTpBBtnu9fp6cX5H_5gq_ox7ugy51QepKpSVankK4BXLtd5bucx5SWVMHNBpWjXUa-QXodonXeU0T37ok4X4vO5PD-AqbzVuIHtjaEd1ZNarJZvfv3cvEeFf9crvFFvW4wRFD3J0ilZ9BSDoVtomDQVNDgbvf3-YJ7nQgsz5jZv7Llrnf5zOf99OXnNFJ0cwd3Rh2QfBqbfg4NQ34fbQ1XJzQP4_ZXgWEPJLqoeZQlJy-n1Batq1kNusLbDQ-KqWbWsicxPAMfM-m4d2HKDTG4cetY4BVuG7ke4qCyz9fVB7V_Otozuc3Fw8kFbnLqibyeB0a-J4c73ISxOPn37eJqOxRdSL1S2xpAy87wUouRl1NJbLqPNtPLcY9DMFXqNmRPORmUNRnioxoFHkUdJn7G9R9V-BId1U4cnwMitcl5EL50iBthooiyldLnX1s1mCWTTphd-RCanAhnLoo9QjCoGPhXIp4L4VOQJvN52uRxgOfYRH0-cLCYBK3JjBKecq0ng5bYZdYsSJrYOTUc0GqNBjkfUPpq55nouJU_g8SAc2xVRGahMKJmA3hGbLQFhe--21NX3HuNbckKCM0_3L_0Z3Jn1wsvxtDuGw_WqC8_RSVq7F73o_wGFwBNl
  priority: 102
  providerName: Scholars Portal
Title Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation
URI https://www.ncbi.nlm.nih.gov/pubmed/28320465
https://www.proquest.com/docview/1884384168
https://www.proquest.com/docview/1879663638
https://www.proquest.com/docview/1897379553
https://pubmed.ncbi.nlm.nih.gov/PMC5359958
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba9RAFB60RfBFvJtalxF8EkIzO9d9EpXWIrRIsbBvYWYyg6HbpDYbof-jP9hzcmtXYV_yMicXcu7nzHyHkA-OacbsIqa8wBFmLqgU_DroFdDrEK3zDju6J6fq-Fx8X8rlUHBrhm2Vo03sDHVRe6yRHzBjBMcemfl09TvFqVHYXR1GaDwkuwhdhlKtl3qqsYAvFFqYoZnJjDpoIJ1QuHtLp-j8U7bpjv6LMf_dKnnP9xw9JU-GoJF-7rn8jDwI1XPyqB8jefOC3J4h_moo6GXZwSoBaTFut6BlRTuMDdq0YBX-1NcNrSP1I6Ixtb5dB7q6Aa7WDkJpeAVdhfYiXJaW2ur-Q-0dKxuKBVx4OAadDby6xHMmgeIxib7I-5KcHx3-_HqcDtMWUi9UtoYcMvO8EKLgRdTSWy6jzbTy3EOWzBWEiZkTzkZlDaR0oLeBR8GixNPX3oMuvyI7VV2FN4RiHOW8iF46hQyw0URZSOmY19bN5wnJxp-e-wGKHCdirPIuJTEq7_mUA59y5FPOEvJxuuWqx-HYRrw_cjIfVLLJ7wQoIe-nZVAm7JDYKtQt0mhI_zjYpG00C831QkqekNe9cExfhHOfMqFkQvSG2EwECOa9uVKVvzpQb8kR-s3sbf_0t-TxvBNeDuZtn-ysr9vwDqKitZt1oj8ju18OT3-czbraAly_LRlcT4T5CyXkFNw
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIgQXxJu0BYwEF6SoSfzKHhBCQLWljwNqpb0F27HViG1Smg1o_we_g9_ITF7tgrS3nj1JrMzneXjsbwh5bWIVx3riQ5ZjCzPjZAh-HdYVyCvntbEGK7pHx3J6yr_MxGyD_BnuwuCxysEmtoY6ryzuke_GacoZ1sjS9xc_QuwahdXVoYVGB4sDt_wFKVv9bv8T6PdNkux9Pvk4DfuuAqHlMlpArhRZlnOes9wrYTUTXkMyb5mFbJBJCIciw432UqeQugA-HfM89gJvGVsbYZcIMPm3wPFGmOypmRr3dMD3csXTvngap3K3hvRF4mkxFWKwEcar7u-_mPbfo5nXfN3efXKvD1Lphw5VD8iGKx-S213byuUj8vsr8r26nJ4XLY0TiObD8Q5alLTl9KB1A1boZ3VZ08pTOzAoU22bhaPzJaCoMhC6wyfo3DXf3XmhqS6vv1RfQaemuGEML8cgt4ZPF3ivxVG8ltFtKj8mpzeihydks6xK94xQjNuM5d4KI1EB2qde5EKY2CptkiQg0fDTM9tTn2MHjnnWpkCpzDo9ZaCnDPWUxQF5Oz5y0fF-rBPeGTSZ9Sagzq4AG5BX4zAsXqzI6NJVDcooSDcZ2MB1MhPF1EQIFpCnHTjGGWGfqYhLERC1AptRAMnDV0fK4qwlERcMqebSrfVTf0nuTE-ODrPD_eODbXI3aYHMwLTukM3FZeOeQ0S2MC_aZUDJt5ted38BbSFMBw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reduced+microbial+diversity+in+adult+survivors+of+childhood+acute+lymphoblastic+leukemia+and+microbial+associations+with+increased+immune+activation&rft.jtitle=Microbiome&rft.au=Chua%2C+Ling+Ling&rft.au=Rajasuriar%2C+Reena&rft.au=Mohamad+Shafiq+Azanan&rft.au=Noor%2C+Kamila+Abdullah&rft.date=2017-03-20&rft.pub=BioMed+Central&rft.eissn=2049-2618&rft.volume=5&rft_id=info:doi/10.1186%2Fs40168-017-0250-1
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2049-2618&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2049-2618&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2049-2618&client=summon