CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

• Published in: The Journal of experimental medicine Vol. 221; no. 2
• Main Authors: Lund, Harald, Hunt, Matthew A., Kurtović, Zerina, Sandor, Katalin, Kägy, Paul B., Fereydouni, Noah, Julien, Anais, Göritz, Christian, Vazquez-Liebanas, Elisa, Andaloussi Mäe, Maarja, Jurczak, Alexandra, Han, Jinming, Zhu, Keying, Harris, Robert A., Lampa, Jon, Graversen, Jonas Heilskov, Etzerodt, Anders, Haglund, Lisbet, Yaksh, Tony L., Svensson, Camilla I.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 05.02.2024
• Subjects: Cardiovascular Biology; Endothelial Cells; Ganglia, Spinal; Humans; Innate immunity and inflammation; Macrophages; Neuroinflammation; Pericytes; Permeability
• ISSN: 0022-1007; 1540-9538; 1540-9538
• DOI: 10.1084/jem.20230675

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have largely been explored in the context of pain, nerve injury, and repair. However, we discovered that most DRG macrophages interact with and monitor the vasculature by sampling macromolecules from the blood. Characteriz...