Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2

• Published in: Nanotoxicology Vol. 11; no. 4; pp. 443 - 453
• Main Authors: Kreyling, Wolfgang G., Holzwarth, Uwe, Schleh, Carsten, Kozempel, Ján, Wenk, Alexander, Haberl, Nadine, Hirn, Stephanie, Schäffler, Martin, Lipka, Jens, Semmler-Behnke, Manuela, Gibson, Neil
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.05.2017; Taylor & Francis Ltd
• Subjects: Accumulation; accumulation in secondary organs and tissues; Administration, Oral; Animals; Blood; Brain; Circulation; Consumers; different biokinetics pattern after gavage versus intravenous injection; Dioxides; Dose-Response Relationship, Drug; Environmental Pollutants - administration & dosage; Environmental Pollutants - blood; Environmental Pollutants - pharmacokinetics; Environmental Pollutants - urine; Esophagus; Excretion; Exposure; Feces - chemistry; Female; Gastrointestinal Tract - metabolism; gavage; gut-absorption; Health; Injection; Intestine; Ions; Kidneys; Liver; Lungs; Metabolic Clearance Rate; Nanoparticles; Nanoparticles - administration & dosage; Normalizing; Oral cavity; Organs; Particle Size; Particulates; Radioisotopes; Rats; Rats, Inbred WKY; Retention; Sensitivity; Size-selected, radiolabeled titanium dioxide nanoparticles; Spleen; Surface Properties; Time Factors; Tissue Distribution; Tissues; Titanium - administration & dosage; Titanium - blood; Titanium - pharmacokinetics; Titanium - urine; Titanium dioxide; Uterus; Vanadium; gavage; Size-selected, radiolabeled titanium dioxide nanoparticles; different biokinetics pattern after gavage versus intravenous injection; gut-absorption; accumulation in secondary organs and tissues

The biokinetics of a size-selected fraction (70 nm median size) of commercially available and 48 V-radiolabeled [ 48 V]TiO 2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1 h, 4 h, 24 h and 7 days after oral application of a single dose of an aqueous [ 48 V]...