Impaired Maternal‐Fetal Environment and Risk for Preoperative Focal White Matter Injury in Neonates With Complex Congenital Heart Disease

• Published in: Journal of the American Heart Association Vol. 12; no. 7; p. e025516
• Main Authors: Licht, Daniel J., Jacobwitz, Marin, Lynch, Jennifer M., Ko, Tiffany, Boorady, Timothy, Devarajan, Mahima, Heye, Kristina N., Mensah‐Brown, Kobina, Newland, John J., Schmidt, Alexander, Schwab, Peter, Winters, Madeline, Nicolson, Susan C., Montenegro, Lisa M., Fuller, Stephanie, Mascio, Christopher, Gaynor, J. William, Yodh, Arjun G., Gebb, Juliana, Vossough, Arastoo, Choi, Grace H., Putt, Mary E.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 04.04.2023; Wiley
• Subjects: Brain Injuries - diagnostic imaging; Brain Injuries - epidemiology; Brain Injuries - etiology; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - methods; congenital brain injuries; Female; heart defects; Heart Defects, Congenital - epidemiology; Heart Defects, Congenital - pathology; Heart Defects, Congenital - surgery; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging - methods; Male; maternal fetal environment; Original Research; placenta; Pregnancy; Prospective Studies; Risk Factors; White Matter - diagnostic imaging; White Matter - pathology; white matter injury; maternal fetal environment; placenta; heart defects; risk factors; congenital brain injuries; white matter injury

Background Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal heart surgery. Better knowledge of the causes of preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients. Methods and Results A...