Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals
The unfolded protein response is an adaptive stress response that responds to the imbalance between the entry of newly synthesized unfolded proteins and the inherent folding capacity in the endoplasmic reticulum (ER). Various environmental stresses and changes in physiological conditions can result...
Saved in:
| Published in | Journal of biochemistry (Tokyo) Vol. 147; no. 1; pp. 27 - 33 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
England
Japanese Biochemical Society
2010
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The unfolded protein response is an adaptive stress response that responds to the imbalance between the entry of newly synthesized unfolded proteins and the inherent folding capacity in the endoplasmic reticulum (ER). Various environmental stresses and changes in physiological conditions can result in the accumulation of unfolded proteins in the ER, which is sensed through ER transmembrane protein sensors named inositol requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating transcription factor 6 (ATF6), and the sensed signals are transduced to the cytosol and the nucleus. IRE1 is a prototype ER stress sensor that is evolutionarily conserved from yeast to humans. Higher eukaryotes have evolved two other sensors, PERK and ATF6. This review focuses on the current progress in our understanding of stress-sensing mechanisms, in particular, the similarities and differences between yeast and mammals. |
|---|---|
| AbstractList | The unfolded protein response is an adaptive stress response that responds to the imbalance between the entry of newly synthesized unfolded proteins and the inherent folding capacity in the endoplasmic reticulum (ER). Various environmental stresses and changes in physiological conditions can result in the accumulation of unfolded proteins in the ER, which is sensed through ER transmembrane protein sensors named inositol requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating transcription factor 6 (ATF6), and the sensed signals are transduced to the cytosol and the nucleus. IRE1 is a prototype ER stress sensor that is evolutionarily conserved from yeast to humans. Higher eukaryotes have evolved two other sensors, PERK and ATF6. This review focuses on the current progress in our understanding of stress-sensing mechanisms, in particular, the similarities and differences between yeast and mammals. |
| Author | Kohno, Kenji |
| Author_xml | – sequence: 1 fullname: Kohno, Kenji |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19942680$$D View this record in MEDLINE/PubMed |
| BookMark | eNp90E1v1DAQBmALtaLbwoE_ADkgIQ6h_khipzda0RapElRt0YqL5cST1kvsBE8C9N_jJSu4cRrNzKNXozkke2EIQMgLRt8xWovjTXPsf4ysrp6QFZNllfOqZHtkRSlnec2L9QE5RNxsWy7EU3LA6rrglaIrEm-mCIg5QkAX7jMP7YMJDj1mLmTTA2Rz6Ibegs3GOEyQhsmPQ0A4ydB515voJgeYmWAz67oOIoQ29Q1MPwFC9ggGpz9bb7w3PT4j-10q8HxXj8jd-Yfbs8v86tPFx7P3V3lbVHTKS6a4stJAKwx0JW14La01bWFKZdvS0kYBpZYpZTolSiupaBpbcCZV17RpdETeLLnp8O8z4KS9wxb63gQYZtRSiFKplJrk20W2cUCM0OkxOm_io2ZUbz-sN41ePpzsy13q3Hiw_-TupQm8XsAwj__NyRfmcIJff6GJ33QlhSz15fqr_nIuP5-uT6_19sZXi-_MoM19dKjvbjhlgjLJeS2E-A2KXaEE |
| CitedBy_id | crossref_primary_10_1016_j_cellsig_2014_09_003 crossref_primary_10_3390_ijms21114171 crossref_primary_10_1111_1574_6976_12020 crossref_primary_10_1155_2012_743780 crossref_primary_10_1002_wrna_78 crossref_primary_10_1093_jb_mvv010 crossref_primary_10_1093_nar_gkr132 crossref_primary_10_1186_1475_2859_9_49 crossref_primary_10_1016_j_it_2015_05_006 crossref_primary_10_1016_j_yexcr_2015_04_010 crossref_primary_10_1099_vir_0_071845_0 crossref_primary_10_1007_s00253_011_3784_3 crossref_primary_10_1016_j_freeradbiomed_2012_02_048 crossref_primary_10_3109_10409238_2012_694845 crossref_primary_10_1111_j_1365_2958_2010_07522_x crossref_primary_10_4161_viru_26571 crossref_primary_10_1146_annurev_cellbio_101011_155826 crossref_primary_10_6064_2012_857516 crossref_primary_10_1007_s00253_015_6470_z crossref_primary_10_1093_hmg_ddr445 crossref_primary_10_1247_csf_10014 crossref_primary_10_1155_2012_507986 crossref_primary_10_4161_viru_26772 crossref_primary_10_1111_1751_7915_12350 crossref_primary_10_1155_2012_182834 crossref_primary_10_1038_s41598_021_04654_1 crossref_primary_10_1016_j_febslet_2013_09_008 crossref_primary_10_1074_jbc_M110_145334 crossref_primary_10_1007_s00253_021_11336_5 crossref_primary_10_1002_yea_1718 crossref_primary_10_1016_j_cyto_2012_04_003 crossref_primary_10_1016_j_febslet_2014_09_021 crossref_primary_10_3390_ijms21218014 crossref_primary_10_1111_febs_17011 crossref_primary_10_1371_journal_pone_0014291 crossref_primary_10_1093_femsyr_fow049 crossref_primary_10_1371_journal_pone_0185089 crossref_primary_10_1084_jem_20122341 crossref_primary_10_2217_fmb_12_133 crossref_primary_10_1016_j_freeradbiomed_2015_03_030 crossref_primary_10_1073_pnas_1212484110 crossref_primary_10_1016_j_bej_2016_05_013 crossref_primary_10_1016_j_leukres_2012_08_018 crossref_primary_10_3390_biom13030441 crossref_primary_10_1248_yakushi_15_00292_4 crossref_primary_10_1128_JVI_00627_17 crossref_primary_10_1002_biof_1780 crossref_primary_10_1186_1752_0509_7_16 crossref_primary_10_4161_viru_2_1_13345 crossref_primary_10_1038_srep24217 crossref_primary_10_7554_eLife_46267 crossref_primary_10_1371_journal_pone_0020882 crossref_primary_10_1089_ars_2014_5844 crossref_primary_10_1016_j_jbiotec_2018_07_035 crossref_primary_10_1111_j_1462_5822_2011_01684_x crossref_primary_10_1371_journal_pone_0015532 crossref_primary_10_1128_JVI_02247_10 crossref_primary_10_1534_g3_118_201000 crossref_primary_10_1007_s00709_011_0282_5 crossref_primary_10_1038_srep04177 crossref_primary_10_1007_s10646_012_0903_6 crossref_primary_10_1016_j_yexcr_2020_112240 crossref_primary_10_1016_j_domaniend_2012_04_006 crossref_primary_10_1016_j_regpep_2011_11_008 crossref_primary_10_1371_journal_pone_0099298 crossref_primary_10_1038_onc_2010_636 crossref_primary_10_1016_j_jbc_2023_105274 crossref_primary_10_1016_j_bbrc_2015_12_119 crossref_primary_10_1111_cei_12638 crossref_primary_10_1126_scisignal_2002329 crossref_primary_10_3389_fimmu_2022_940122 crossref_primary_10_1111_gtc_12035 crossref_primary_10_1073_pnas_1604435113 crossref_primary_10_3390_microorganisms12020346 crossref_primary_10_1007_s12035_010_8125_5 crossref_primary_10_1093_hmg_ddr306 crossref_primary_10_1186_1471_2164_15_159 crossref_primary_10_1261_rna_2237610 |
| Cites_doi | 10.1083/jcb.200508145 10.1247/csf.06024 10.1016/j.molcel.2009.02.033 10.1016/j.molcel.2009.08.021 10.1128/MCB.18.12.7499 10.1038/306387a0 10.1128/MCB.00408-06 10.1038/35014014 10.1038/nrm1052 10.1038/35055065 10.1247/csf.07044 10.1038/nature07661 10.1016/S0092-8674(00)81360-4 10.1073/pnas.0509487102 10.1074/jbc.M112454200 10.1016/S0092-8674(01)00611-0 10.1016/j.molcel.2009.04.003 10.1016/j.yexcr.2009.06.009 10.1089/ars.2007.1819 10.1038/355033a0 10.1006/bbrc.2000.3987 10.1016/0092-8674(93)90648-A 10.1146/annurev.biochem.73.011303.074134 10.1083/jcb.200405153 10.1083/jcb.200704166 10.1073/pnas.0910342106 10.1042/BJ20020391 10.1111/j.1365-2443.2005.00921.x 10.1016/S0092-8674(01)00505-0 10.1247/csf.06028 10.1101/gad.12.12.1812 10.1016/j.devcel.2007.07.005 10.1002/j.1460-2075.1996.tb00666.x 10.1046/j.1365-2443.1996.d01-274.x 10.1074/jbc.M004454200 10.1091/mbc.10.11.3787 10.1038/16729 10.1016/0092-8674(93)90521-Q 10.1016/S0092-8674(00)80835-1 10.1016/0092-8674(89)90059-7 10.1242/jcs.002808 10.1093/emboj/17.19.5708 10.1038/nrm2199 10.1016/S1097-2765(00)00133-7 10.1128/MCB.23.21.7448-7459.2003 10.1038/415092a 10.1016/S1534-5807(02)00203-4 10.1073/pnas.0606480103 10.1038/nature07641 10.1074/jbc.271.30.18181 10.1042/BJ20050640 10.1074/jbc.M200903200 |
| ContentType | Journal Article |
| Copyright | The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved 2009 |
| Copyright_xml | – notice: The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved 2009 |
| DBID | FBQ BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1093/jb/mvp196 |
| DatabaseName | AGRIS Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1756-2651 |
| EndPage | 33 |
| ExternalDocumentID | 10_1093_jb_mvp196 19942680 10.1093/jb/mvp196 ark_67375_HXZ_VF7PBXBQ_7 US201301722933 |
| Genre | Journal Article Comparative Study Review |
| GroupedDBID | --- -E4 -~X .2P .55 .CO .GJ .I3 0R~ 18M 1TH 29J 2WC 3O- 4.4 482 48X 53G 5GY 5RE 5WA 5WD 6.Y 70D A8Z AABJS AABMN AAESY AAIMJ AAIYJ AAJKP AAJQQ AAMDB AAMVS AANRK AAOGV AAPQZ AAPXW AAUQX AAVAP AAVLN AAWDT AAYJJ ABDBF ABEFU ABEUO ABIWU ABIXL ABJNI ABNKS ABPTD ABPTK ABQLI ABQTQ ABSAR ABSMQ ABWST ABXZS ABZBJ ACFRR ACGFO ACGFS ACIWK ACNCT ACPQN ACPRK ACUFI ACUTJ ADBBV ADEIU ADEYI ADEZT ADFTL ADGKP ADGZP ADHKW ADHZD ADIPN ADOCK ADORX ADQLU ADRIX ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEHKS AEJOX AEKPW AEKSI AELWJ AEMDU AENEX AENZO AEPUE AEQTP AETBJ AEWNT AFFNX AFFZL AFGWE AFIYH AFOFC AFRAH AFXEN AFYAG AGINJ AGKEF AGKRT AGQXC AGSYK AHXPO AI. AIAGR AIJHB AIKOY AJEEA AKHUL AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX ANFBD APIBT APJGH APWMN AQDSO ARIXL ASAOO ASPBG ATDFG ATTQO AVWKF AXUDD AYOIW AZFZN AZQFJ BAYMD BCRHZ BEYMZ BHONS BQDIO BSWAC BYORX C1A C45 CAG CASEJ CDBKE COF CS3 CXTWN CZ4 DAKXR DFGAJ DILTD DPORF DPPUQ D~K EBD EBS EE~ EJD ELUNK EMOBN ESTFP ESX F5P F9B FBQ FEDTE FHSFR FLUFQ FOEOM FQBLK GAUVT GJXCC H5~ HAR HH5 HVGLF HW0 HZ~ H~9 IOX J21 JSF JSH KAQDR KBUDW KC5 KOP KQ8 KSI KSN L7B M-Z M49 MBTAY MVM N9A NGC NLBLG NOMLY NTWIH NU- NVLIB O0~ O9- OAWHX OBOKY ODMLO OJQWA OJZSN OK1 OVD OWPYF O~Y P2P PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RJT RNI ROL ROX ROZ RUSNO RW1 RXO RZF RZJ RZO SJN SV3 TCN TEORI TKC TLC TN5 TUS TWZ UQL VH1 WH7 WHG X7H X7J X7M XFK XJT Y6R YAYTL YKOAZ YROCO YXANX ZE2 ZGI ZKB ZKX ZXP ~91 ~KM AARHZ AAUAY ABEJV ABMNT ABXVV ACMRT ACZBC ADQBN AEHUL AFSHK AGMDO ATGXG BSCLL H13 AASNB CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c460t-51828d7aec3aef50b297ddac4a58dc5d0b8e00d188af835d703bbd42178fbcf83 |
| ISSN | 0021-924X |
| IngestDate | Fri Oct 25 03:04:40 EDT 2024 Thu Sep 12 17:08:43 EDT 2024 Tue Oct 15 23:38:26 EDT 2024 Wed Aug 28 03:24:41 EDT 2024 Wed Oct 30 09:49:58 EDT 2024 Wed Dec 27 18:54:17 EST 2023 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | BiP unfolded protein response ER stress sensor clustering IRE1 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c460t-51828d7aec3aef50b297ddac4a58dc5d0b8e00d188af835d703bbd42178fbcf83 |
| Notes | istex:A7309BD91A495B13486D2F5703CDE34FDA153D47 ArticleID:mvp196 ark:/67375/HXZ-VF7PBXBQ-7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| OpenAccessLink | https://academic.oup.com/jb/article-pdf/147/1/27/2266228/mvp196.pdf |
| PMID | 19942680 |
| PQID | 733588297 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_733588297 crossref_primary_10_1093_jb_mvp196 pubmed_primary_19942680 oup_primary_10_1093_jb_mvp196 istex_primary_ark_67375_HXZ_VF7PBXBQ_7 fao_agris_US201301722933 |
| PublicationCentury | 2000 |
| PublicationDate | 2010 2010-01 20100100 2010-Jan 2010-01-01 20100101 |
| PublicationDateYYYYMMDD | 2010-01-01 |
| PublicationDate_xml | – year: 2010 text: 2010 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of biochemistry (Tokyo) |
| PublicationTitleAlternate | J Biochem |
| PublicationYear | 2010 |
| Publisher | Japanese Biochemical Society Oxford University Press |
| Publisher_xml | – name: Japanese Biochemical Society – name: Oxford University Press |
| References | (36_29530218) 2007; 179 Bertolotti (29_10353914) 2000; 2 Wu (25_29349913) 2007; 13 Yoshida (18_11465166) 2001; 107 Oikawa (33_19428443) 2005; 391 Gething (1_9691217) 1992; 355 (39_19554567) 2002; 277 Normington (28_5292221) 1989; 57 Cox (6_10264810) 1993; 73 (38_19543961) 2000; 275 Oikawa (34_28419643) 2007; 120 Travers (20_10345864) 2000; 101 (45_21583374) 2006; 172 Ellgaard (2_17520560) 2003; 4 Oikawa (40_35105708) 2009; 315 (32_18513806) 2004; 167 Kaufman (15_16282795) 1996; 271 Tirasophon (11_6051480) 1998; 12 Kimata (21_21288779) 2006; 11 Shamu (14_16277390) 1996; 15 Korennykh (42_32935932) 2009; 457 Yoshida (46_33514127) 2009; 34 Mori (7_14427149) 1993; 74 Nadanaka (49_23291117) 2006; 31 Ron (47_34691094) 2009; 34 Harding (8_10717618) 1999; 397 Ron (3_28931022) 2007; 8 Haas (27_13044888) 1983; 306 Okada (24_17202834) 2002; 366 Hetz (5_35591812) 2009; 35 Kohno (52_29831714) 2007; 9 (48_19554618) 2002; 277 (51_35727377) 2009; 106 Shi (9_6233884) 1998; 18 R egsegger (44_11353605) 2001; 107 Okamura (30_10582608) 2000; 279 (35_21149952) 2005; 102 Ye (23_10639268) 2000; 6 Shen (31_17140223) 2002; 3 Adachi (26_31070848) 2008; 33 (50_22976344) 2007; 27 Mori (17_16605212) 1996; 1 Iwawaki (13_11047265) 2001; 3 Calfon (19_11465747) 2002; 415 Schr der (4_19029882) 2005; 74 Wang (12_6168972) 1998; 17 Cox (16_16491644) 1996; 87 Aragon (41_32935933) 2009; 457 Yanagitani (43_34691102) 2009; 34 Lee (22_17858298) 2003; 23 (37_22592085) 2006; 103 Haze (10_6369923) 1999; 10 |
| References_xml | – volume: 172 start-page: 565 issn: 0021-9525 issue: 4 year: 2006 ident: 45_21583374 publication-title: The Journal of Cell Biology doi: 10.1083/jcb.200508145 – volume: 31 start-page: 127 issn: 0386-7196 issue: 2 year: 2006 ident: 49_23291117 publication-title: Cell structure and function doi: 10.1247/csf.06024 contributor: fullname: Nadanaka – volume: 34 start-page: 191 issn: 1097-2765 issue: 2 year: 2009 ident: 43_34691102 publication-title: Molecular cell doi: 10.1016/j.molcel.2009.02.033 contributor: fullname: Yanagitani – volume: 35 start-page: 551 issn: 1097-2765 issue: 5 year: 2009 ident: 5_35591812 publication-title: Molecular cell doi: 10.1016/j.molcel.2009.08.021 contributor: fullname: Hetz – volume: 18 start-page: 7499 issn: 0270-7306 issue: 12 year: 1998 ident: 9_6233884 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.18.12.7499 contributor: fullname: Shi – volume: 306 start-page: 387 issn: 1476-4687 issue: 5941 year: 1983 ident: 27_13044888 publication-title: Nature; Physical Science (London) doi: 10.1038/306387a0 contributor: fullname: Haas – volume: 27 start-page: 1027 issn: 0270-7306 issue: 3 year: 2007 ident: 50_22976344 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00408-06 – volume: 2 start-page: 326 issn: 1476-4679 issue: 6 year: 2000 ident: 29_10353914 publication-title: Nature Cell Biology doi: 10.1038/35014014 contributor: fullname: Bertolotti – volume: 4 start-page: 181 issn: 1471-0072 issue: 3 year: 2003 ident: 2_17520560 publication-title: Nature reviews. Molecular cell biology doi: 10.1038/nrm1052 contributor: fullname: Ellgaard – volume: 3 start-page: 158 issn: 1476-4679 issue: 2 year: 2001 ident: 13_11047265 publication-title: Nature Cell Biology doi: 10.1038/35055065 contributor: fullname: Iwawaki – volume: 33 start-page: 75 issn: 0386-7196 issue: 1 year: 2008 ident: 26_31070848 publication-title: Cell structure and function doi: 10.1247/csf.07044 contributor: fullname: Adachi – volume: 457 start-page: 687 issn: 1476-4687 issue: 7230 year: 2009 ident: 42_32935932 publication-title: Nature; Physical Science (London) doi: 10.1038/nature07661 contributor: fullname: Korennykh – volume: 87 start-page: 391 issn: 0092-8674 issue: 3 year: 1996 ident: 16_16491644 publication-title: Cell doi: 10.1016/S0092-8674(00)81360-4 contributor: fullname: Cox – volume: 102 start-page: 18773 issn: 0027-8424 issue: 52 year: 2005 ident: 35_21149952 publication-title: PNAS doi: 10.1073/pnas.0509487102 – volume: 277 start-page: 18346 issn: 0021-9258 issue: 21 year: 2002 ident: 39_19554567 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M112454200 – volume: 107 start-page: 881 issn: 0092-8674 issue: 7 year: 2001 ident: 18_11465166 publication-title: Cell doi: 10.1016/S0092-8674(01)00611-0 contributor: fullname: Yoshida – volume: 34 start-page: 133 issn: 1097-2765 issue: 2 year: 2009 ident: 47_34691094 publication-title: Molecular cell doi: 10.1016/j.molcel.2009.04.003 contributor: fullname: Ron – volume: 315 start-page: 2496 issn: 0014-4827 issue: 15 year: 2009 ident: 40_35105708 publication-title: Experimental cell research doi: 10.1016/j.yexcr.2009.06.009 contributor: fullname: Oikawa – volume: 9 start-page: 2295 issn: 1523-0864 issue: 12 year: 2007 ident: 52_29831714 publication-title: Antioxidants & redox signaling doi: 10.1089/ars.2007.1819 contributor: fullname: Kohno – volume: 355 start-page: 33 issn: 1476-4687 issue: 6355 year: 1992 ident: 1_9691217 publication-title: Nature; Physical Science (London) doi: 10.1038/355033a0 contributor: fullname: Gething – volume: 279 start-page: 445 issn: 0006-291X issue: 2 year: 2000 ident: 30_10582608 publication-title: Biochemical and biophysical research communications doi: 10.1006/bbrc.2000.3987 contributor: fullname: Okamura – volume: 73 start-page: 1197 issn: 0092-8674 issue: 6 year: 1993 ident: 6_10264810 publication-title: Cell doi: 10.1016/0092-8674(93)90648-A contributor: fullname: Cox – volume: 74 start-page: 739 issn: 0066-4154 year: 2005 ident: 4_19029882 publication-title: Annual review of biochemistry doi: 10.1146/annurev.biochem.73.011303.074134 contributor: fullname: Schr der – volume: 167 start-page: 445 issn: 0021-9525 issue: 3 year: 2004 ident: 32_18513806 publication-title: The Journal of Cell Biology doi: 10.1083/jcb.200405153 – volume: 179 start-page: 75 issn: 0021-9525 issue: 1 year: 2007 ident: 36_29530218 publication-title: The Journal of Cell Biology doi: 10.1083/jcb.200704166 – volume: 106 start-page: 17775 issn: 0027-8424 issue: 42 year: 2009 ident: 51_35727377 publication-title: PNAS doi: 10.1073/pnas.0910342106 – volume: 366 start-page: 585 issn: 0264-6021 issue: Pt 2 year: 2002 ident: 24_17202834 publication-title: The Biochemical journal doi: 10.1042/BJ20020391 contributor: fullname: Okada – volume: 11 start-page: 59 issn: 1356-9597 issue: 1 year: 2006 ident: 21_21288779 publication-title: Genes to Cells doi: 10.1111/j.1365-2443.2005.00921.x contributor: fullname: Kimata – volume: 107 start-page: 103 issn: 0092-8674 issue: 1 year: 2001 ident: 44_11353605 publication-title: Cell doi: 10.1016/S0092-8674(01)00505-0 contributor: fullname: R egsegger – volume: 34 start-page: 1 issn: 0386-7196 issue: 1 year: 2009 ident: 46_33514127 publication-title: Cell structure and function doi: 10.1247/csf.06028 contributor: fullname: Yoshida – volume: 12 start-page: 1812 issn: 0890-9369 issue: 12 year: 1998 ident: 11_6051480 publication-title: Genes & Development doi: 10.1101/gad.12.12.1812 contributor: fullname: Tirasophon – volume: 13 start-page: 351 issn: 1534-5807 issue: 3 year: 2007 ident: 25_29349913 publication-title: Developmental cell doi: 10.1016/j.devcel.2007.07.005 contributor: fullname: Wu – volume: 15 start-page: 3028 issn: 0261-4189 issue: 12 year: 1996 ident: 14_16277390 publication-title: The EMBO Journal doi: 10.1002/j.1460-2075.1996.tb00666.x contributor: fullname: Shamu – volume: 1 start-page: 803 issn: 1356-9597 issue: 9 year: 1996 ident: 17_16605212 publication-title: Genes to Cells doi: 10.1046/j.1365-2443.1996.d01-274.x contributor: fullname: Mori – volume: 275 start-page: 24881 issn: 0021-9258 issue: 32 year: 2000 ident: 38_19543961 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M004454200 – volume: 10 start-page: 3787 issn: 1059-1524 issue: 11 year: 1999 ident: 10_6369923 publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.10.11.3787 contributor: fullname: Haze – volume: 397 start-page: 271 issn: 1476-4687 issue: 6716 year: 1999 ident: 8_10717618 publication-title: Nature; Physical Science (London) doi: 10.1038/16729 contributor: fullname: Harding – volume: 74 start-page: 743 issn: 0092-8674 issue: 4 year: 1993 ident: 7_14427149 publication-title: Cell doi: 10.1016/0092-8674(93)90521-Q contributor: fullname: Mori – volume: 101 start-page: 249 issn: 0092-8674 issue: 3 year: 2000 ident: 20_10345864 publication-title: Cell doi: 10.1016/S0092-8674(00)80835-1 contributor: fullname: Travers – volume: 57 start-page: 1223 issn: 0092-8674 issue: 7 year: 1989 ident: 28_5292221 publication-title: Cell doi: 10.1016/0092-8674(89)90059-7 contributor: fullname: Normington – volume: 120 start-page: 1681 issn: 0021-9533 issue: 9 year: 2007 ident: 34_28419643 publication-title: Journal of Cell Science doi: 10.1242/jcs.002808 contributor: fullname: Oikawa – volume: 17 start-page: 5708 issn: 0261-4189 issue: 19 year: 1998 ident: 12_6168972 publication-title: The EMBO Journal doi: 10.1093/emboj/17.19.5708 contributor: fullname: Wang – volume: 8 start-page: 519 issn: 1471-0072 issue: 7 year: 2007 ident: 3_28931022 publication-title: Nature reviews. Molecular cell biology doi: 10.1038/nrm2199 contributor: fullname: Ron – volume: 6 start-page: 1355 issn: 1097-2765 issue: 6 year: 2000 ident: 23_10639268 publication-title: Molecular cell doi: 10.1016/S1097-2765(00)00133-7 contributor: fullname: Ye – volume: 23 start-page: 7448 issn: 0270-7306 issue: 21 year: 2003 ident: 22_17858298 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.23.21.7448-7459.2003 contributor: fullname: Lee – volume: 415 start-page: 92 issn: 1476-4687 issue: 6867 year: 2002 ident: 19_11465747 publication-title: Nature; Physical Science (London) doi: 10.1038/415092a contributor: fullname: Calfon – volume: 3 start-page: 99 issn: 1534-5807 issue: 1 year: 2002 ident: 31_17140223 publication-title: Developmental cell doi: 10.1016/S1534-5807(02)00203-4 contributor: fullname: Shen – volume: 103 start-page: 14343 issn: 0027-8424 issue: 39 year: 2006 ident: 37_22592085 publication-title: PNAS doi: 10.1073/pnas.0606480103 – volume: 457 start-page: 736 issn: 1476-4687 issue: 7230 year: 2009 ident: 41_32935933 publication-title: Nature; Physical Science (London) doi: 10.1038/nature07641 contributor: fullname: Aragon – volume: 271 start-page: 18181 issn: 0021-9258 issue: 30 year: 1996 ident: 15_16282795 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.271.30.18181 contributor: fullname: Kaufman – volume: 391 start-page: 135 issn: 0264-6021 issue: Pt 1 year: 2005 ident: 33_19428443 publication-title: The Biochemical journal doi: 10.1042/BJ20050640 contributor: fullname: Oikawa – volume: 277 start-page: 18728 issn: 0021-9258 issue: 21 year: 2002 ident: 48_19554618 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M200903200 |
| SSID | ssj0021233 |
| Score | 2.2926276 |
| SecondaryResourceType | review_article |
| Snippet | The unfolded protein response is an adaptive stress response that responds to the imbalance between the entry of newly synthesized unfolded proteins and the... |
| SourceID | proquest crossref pubmed oup istex fao |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 27 |
| SubjectTerms | Animals BiP clustering Endoplasmic Reticulum - metabolism ER stress sensor Humans IRE1 Mammals - metabolism Protein Folding Proteins - chemistry Proteins - metabolism Saccharomyces cerevisiae - metabolism Signal Transduction Stress, Physiological unfolded protein response |
| Title | Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals |
| URI | https://api.istex.fr/ark:/67375/HXZ-VF7PBXBQ-7/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/19942680 https://search.proquest.com/docview/733588297 |
| Volume | 147 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9NAEF2l6YULAgo0QNEKoV6QW8efa24JEEUcEKgJijiw2rXXyGkdV3GCCL-emd116rQUARcrshXb8nueD--bGUJe5iKBtEFJp58Lzwli1XckExJe90ClCcORIrrb54doPA3ez8JZp_O1pVpar-RJ-vO3dSX_gyrsA1yxSvYfkN2eFHbAb8AXtoAwbP8K4zNd6OHUKEKHjL9UWMZb1GXdqBfXcJGLTGErgArHWr5aGkmsLkivi7KAvFa3VNVrCM2wFBRpNfqtDc720UdLUZbior4lmpUFjt4ys-Mwap1U55uq9ZkBS2sqWwg0L9rfGqzeVHsA8Nw4ERMnZKZNJwOrK22bV9R7eEZyeaKMRY3DyPEi21W2Mbmmy-YOt6wBjVuu2LTIuGHkTQOsuYRN-f2yn1xrpa2d8_TMwzVZCM8gnvH3yL6HjQC7ZH8wfDscbVNy8NtGg2BvvOk9lfinc3lqzr4TsezlooI8Bl_BH9dqIm-kJjpEmdwjdy0adGCIcp901OIBORgsxKoqN_SYarWvXkY5IMtd7tAr7tBiQYE7tOEOtdyhDXde0zZzKHCDtphDLXOoZo4-apnzkExH7yZvxo6dv-GkQeSunBByT5bFQqW-UHnoSi-Js0ykgQhZloaZK5ly3azPmMghkM_AeUiZBZDkslymsOsR6S6qhToklMkwjSE1j4QPIat0ZcrAhIlQgjHIooT1yIvmGfNL02aFG3mEz-eSGyB65BCePhffwP3xXYB75FhDsv2zWJ6jZDEO-Xj2hX8exR-Hs-EnHvfIEWD2p2vQBk0O7wyungHxq3XNY98PGRai98hjg_LVWZIEAl3mPrn9Bp-SO0Z3gh_vnpHuarlWRxDOruRzy8lfu0Wkvg |
| link.rule.ids | 315,783,787,4033,27937,27938,27939 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stress-sensing+mechanisms+in+the+unfolded+protein+response%3A+similarities+and+differences+between+yeast+and+mammals&rft.jtitle=Journal+of+biochemistry+%28Tokyo%29&rft.au=Kohno%2C+Kenji&rft.date=2010&rft.pub=Japanese+Biochemical+Society&rft.issn=0021-924X&rft.eissn=1756-2651&rft.volume=147&rft.issue=1&rft.spage=27&rft.epage=33&rft_id=info:doi/10.1093%2Fjb%2Fmvp196&rft.externalDocID=US201301722933 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-924X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-924X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-924X&client=summon |