Postoperative Ileus-Related Morbidity Profile in Patients Treated with Alvimopan after Bowel Resection

• Published in: Journal of the American College of Surgeons Vol. 204; no. 4; pp. 609 - 616
• Main Authors: Wolff, Bruce G., MD, Weese, James L., MD, FACS, Ludwig, Kirk A., MD, Delaney, Conor P., MD, PhD, Stamos, Michael J., MD, FACS, FASCRS, Michelassi, Fabrizio, MD, Du, Wei, PhD, Techner, Lee, DPM
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2007; Elsevier Science
• Subjects: Biological and medical sciences; Digestive System Surgical Procedures - adverse effects; Double-Blind Method; Epidemiology; Female; Gastrointestinal Agents - therapeutic use; General aspects; Humans; Ileus - etiology; Ileus - prevention & control; Male; Medical sciences; Middle Aged; Piperidines - therapeutic use; Postoperative Complications - prevention & control; Public health. Hygiene; Public health. Hygiene-occupational medicine; Receptors, Opioid, mu - antagonists & inhibitors; Surgery; gastrointestinal; LOS; GI; nasogastric tube; NNT; postoperative ileus; length of stay; NGT; POI; morphine sulfate equivalent; number needed to treat; MSE; Human; Postoperative; Alvimopan; μ Opioid receptor; Gut; Patient; Surgical resection; Epidemiology; Morbidity; Profile; Medicine; Treatment; Surgery; Antagonist

Background Postoperative ileus (POI), an interruption of coordinated bowel motility after operation, is exacerbated by opioids used to manage pain. Alvimopan, a peripherally acting μ-opioid receptor antagonist, accelerated gastrointestinal (GI) recovery after bowel resection in randomized, double-bl...