Lineage Differentiation Program of Invariant Natural Killer T Cells

• Published in: Immune network Vol. 17; no. 6; pp. 365 - 377
• Main Authors: Kwon, Dong-il, Lee, You Jeong
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한면역학회 01.12.2017; The Korean Association of Immunologists
• Subjects: Review; 면역학; Growth and development; Natural killer T cells; Thymus gland

Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages. Promyelocytic leukemia zinc finger (PLZF) modulates this process, and P...