Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment

• Published in: British journal of cancer Vol. 55; no. 3; pp. 245 - 248
• Main Authors: HOLDEN, S. A, TEICHER, B. A, BOECHEIM, K, WEICHSELBAUM, R. R, ERVIN, T. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.1987
• Subjects: Antineoplastic agents; Biological and medical sciences; Bleomycin - therapeutic use; Carcinoma, Squamous Cell - drug therapy; Cell Line; Cell Survival - drug effects; Cisplatin - pharmacology; Dose-Response Relationship, Drug; General aspects; Head and Neck Neoplasms - drug therapy; Humans; Medical sciences; Organoplatinum Compounds - therapeutic use; Pharmacology. Drug treatments; Time Factors; Antineoplastic agent; Potentiation; In vivo; Squamous cell carcinoma; DNA; Interaction; Established cell line; Head and neck; Repair; Tumor cell; Platinum II Complexes

The SCC-25 cell line is a well-established line derived from a human squamous carcinoma of the head and neck. The capacity of this cell line for recovery from potentially lethal damage following X-ray treatment has been documented. The survival curve of stationary phase SCC-25 cells exposed to vario...