White spot syndrome virus protein kinase 1 defeats the host cell's iron-withholding defense mechanism by interacting with host ferritin

• Published in: Journal of virology Vol. 89; no. 2; pp. 1083 - 1093
• Main Authors: Lin, Shin-Jen, Lee, Der-Yen, Wang, Hao-Ching, Kang, Shih-Ting, Hwang, Pung-Pung, Kou, Guang-Hsiung, Huang, Ming-Fen, Chang, Geen-Dong, Lo, Chu-Fang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.01.2015
• Subjects: Animals; Cell Line; Centrifugation; Defense Mechanisms; Ferritins - metabolism; Host-Pathogen Interactions; Iron - metabolism; Protein Binding; Protein Interaction Mapping; Protein Kinases - metabolism; Quartz Crystal Microbalance Techniques; Two-Hybrid System Techniques; Viral Proteins - metabolism; Virus-Cell Interactions; White spot syndrome virus; White spot syndrome virus 1 - physiology

Iron is an essential nutrient for nearly all living organisms, including both hosts and invaders. Proteins such as ferritin regulate the iron levels in a cell, and in the event of a pathogenic invasion, the host can use an iron-withholding mechanism to restrict the availability of this essential nut...