Comparative transcriptomics reveals human-specific cortical features

• Published in: Science (American Association for the Advancement of Science) Vol. 382; no. 6667; p. eade9516
• Main Authors: Jorstad, Nikolas L., Song, Janet H. T., Exposito-Alonso, David, Suresh, Hamsini, Castro-Pacheco, Nathan, Krienen, Fenna M., Yanny, Anna Marie, Close, Jennie, Gelfand, Emily, Long, Brian, Seeman, Stephanie C., Travaglini, Kyle J., Basu, Soumyadeep, Beaudin, Marc, Bertagnolli, Darren, Crow, Megan, Ding, Song-Lin, Eggermont, Jeroen, Glandon, Alexandra, Goldy, Jeff, Kiick, Katelyn, Kroes, Thomas, McMillen, Delissa, Pham, Trangthanh, Rimorin, Christine, Siletti, Kimberly, Somasundaram, Saroja, Tieu, Michael, Torkelson, Amy, Feng, Guoping, Hopkins, William D., Höllt, Thomas, Keene, C. Dirk, Linnarsson, Sten, McCarroll, Steven A., Lelieveldt, Boudewijn P., Sherwood, Chet C., Smith, Kimberly, Walsh, Christopher A., Dobin, Alexander, Gillis, Jesse, Lein, Ed S., Hodge, Rebecca D., Bakken, Trygve E.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 13.10.2023
• Subjects: Animals; Apes; Biological evolution; Cerebral cortex; Chimpanzees; Cognition; Cognitive ability; Depth profiling; Divergence; Evolution; Gene expression; Gene Expression Profiling; Gene sequencing; Genes; Genomics; Gorilla gorilla - genetics; Hominidae - genetics; Hominidae - physiology; Humans; Language; Macaca mulatta - genetics; Monkeys & apes; Neocortex - physiology; Neural networks; Neuronal-glial interactions; Neurons; Pan troglodytes - genetics; Phylogeny; Primates; Signal transduction; snRNA; Species; Species Specificity; Synapses; Taxonomy; Temporal gyrus; Temporal lobe; Temporal Lobe - physiology; Transcriptome; Transcriptomics

The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, and...