The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system

The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high p...

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Published inPhysiological measurement Vol. 37; no. 5; pp. 649 - 660
Main Authors Byrne, Patrick, Mostafaei, Farshad, Liu, Yingzi, Blake, Scott P, Koltick, David, Nie, Linda H
Format Journal Article
LanguageEnglish
Published England IOP Publishing 01.05.2016
Subjects
aluminum
Aluminum - analysis
Bone and Bones - chemistry
Bone and Bones - diagnostic imaging
Calibration
Computer Simulation
Equipment Design
Feasibility Studies
Gamma Rays
Germanium
Humans
Monte Carlo Method
neutron activation analysis
Neutron Activation Analysis - instrumentation
Neutron Activation Analysis - methods
neutron generator
Phantoms, Imaging
Radiation Dosage
Water
Online AccessGet full text
ISSN0967-3334
1361-6579
DOI10.1088/0967-3334/37/5/649

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Abstract The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g−1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.
AbstractList The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g(-1) dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.
The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μg g−1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.
The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 mu g g super(-1) dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.
The feasibility and methodology of using a compact DD generator-based neutron activation analysis system to measure aluminum in hand bone has been investigated. Monte Carlo simulations were used to simulate the moderator, reflector, and shielding assembly and to estimate the radiation dose. A high purity germanium (HPGe) detector was used to detect the Al gamma ray signals. The minimum detectable limit (MDL) was found to be 11.13 μ g g −1 dry bone (ppm). An additional HPGe detector would improve the MDL by a factor of 1.4, to 7.9 ppm. The equivalent dose delivered to the irradiated hand was calculated by Monte Carlo to be 11.9 mSv. In vivo bone aluminum measurement with the DD generator was found to be feasible among general population with an acceptable dose to the subject.
Author Koltick, David
Byrne, Patrick
Nie, Linda H
Liu, Yingzi
Mostafaei, Farshad
Blake, Scott P
AuthorAffiliation 2 Physics Department, Purdue University, West Lafayette, IN 47907, USA
1 School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
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SubjectTerms aluminum
Aluminum - analysis
Bone and Bones - chemistry
Bone and Bones - diagnostic imaging
Calibration
Computer Simulation
Equipment Design
Feasibility Studies
Gamma Rays
Germanium
Humans
Monte Carlo Method
neutron activation analysis
Neutron Activation Analysis - instrumentation
Neutron Activation Analysis - methods
neutron generator
Phantoms, Imaging
Radiation Dosage
Water
Title The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system
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