Preparation and Biological Evaluation of [99mTc]Tc-CNGU as a PSMA-Targeted Radiotracer for the Imaging of Prostate Cancer

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 23; p. 5548
• Main Authors: Xiao, Di, Duan, Xiaojiang, Gan, Qianqian, Zhang, Xuran, Zhang, Junbo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.11.2020; MDPI
• Subjects: 99mTc; Animals; Antigens, Surface - metabolism; Chromatography; Glutamate Carboxypeptidase II - metabolism; Humans; isonitrile; Kidneys; Ligands; Male; Mice; Molecular Imaging - methods; Molecular Structure; Nitriles - chemistry; NMR; Nuclear magnetic resonance; Organotechnetium Compounds - chemistry; Prostate cancer; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; PSMA; Radioactive Tracers; Radiopharmaceuticals; SPECT imaging; Technetium - chemistry; Tomography, Emission-Computed, Single-Photon - methods; 99mTc; PSMA; prostate cancer; SPECT imaging; isonitrile

Prostate-specific membrane antigen (PSMA) is a well-established biological target that is overexpressed on the surface of prostate cancer lesions. Radionuclide-labeled small-molecule PSMA inhibitors have been shown to be promising PSMA-specific agents for the diagnosis and therapy of prostate cancer...