Deriving a genetic regulatory network from an optimization principle

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 122; no. 1; p. e2402925121
• Main Authors: Sokolowski, Thomas R., Gregor, Thomas, Bialek, William, Tkačik, Gašper
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.01.2025
• Subjects: Animals; Biological Physics; Configuration management; Drosophila - genetics; Drosophila melanogaster - genetics; Embryo, Nonmammalian - metabolism; Gene expression; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Models, Genetic; Optimization; Physical Sciences; Physics; gene regulatory networks; evolution; optimization; Drosophila

Many biological systems operate near the physical limits to their performance, suggesting that aspects of their behavior and underlying mechanisms could be derived from optimization principles. However, such principles have often been applied only in simplified models. Here, we explore a detailed me...