Influence of the nucleus area distribution on the survival fraction after charged particles broad beam irradiation

• Published in: Physics in medicine & biology Vol. 59; no. 15; pp. 4197 - 4211
• Main Authors: Wéra, A-C, Barazzuol, L, Jeynes, J C G, Merchant, M J, Suzuki, M, Kirkby, K J
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 07.08.2014
• Subjects: Cell Nucleus - radiation effects; Cell Survival; heavy charged particles; Heavy Ions; Linear Energy Transfer; lq model; Models, Theoretical; nucleus area distribution; poisson statistics; survival fraction

It is well known that broad beam irradiation with heavy ions leads to variation in the number of hit(s) received by each cell as the distribution of particles follows the Poisson statistics. Although the nucleus area will determine the number of hit(s) received for a given dose, variation amongst it...