Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis

• Published in: Rheumatology (Oxford, England) Vol. 52; no. 5; pp. 790 - 799
• Main Authors: Noda, S., Asano, Y., Takahashi, T., Akamata, K., Aozasa, N., Taniguchi, T., Ichimura, Y., Toyama, T., Sumida, H., Kuwano, Y., Yanaba, K., Tada, Y., Sugaya, M., Kadono, T., Sato, S.
• Format: Journal Article
• Language: English
• Published: England 01.05.2013
• Subjects: Adult; Aged; Biopsy, Needle; Case-Control Studies; Cathepsins - genetics; Cathepsins - metabolism; Cysteine Endopeptidases - genetics; Cysteine Endopeptidases - metabolism; Disease Progression; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis - genetics; Fibrosis - pathology; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Middle Aged; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - pathology; Prognosis; Proto-Oncogene Protein c-fli-1 - deficiency; Real-Time Polymerase Chain Reaction; Reference Values; RNA - metabolism; Scleroderma, Diffuse - genetics; Scleroderma, Diffuse - pathology; Scleroderma, Systemic - blood; Scleroderma, Systemic - genetics; Scleroderma, Systemic - pathology; Sensitivity and Specificity; Severity of Illness Index

Cathepsin V (CTSV) is a proteolytic enzyme potentially modulating angiogenic processes, collagen degradation and keratinocyte differentiation. We aimed to investigate the clinical association of serum CTSV levels and the mechanism by which CTSV expression is altered in SSc. Serum CTSV levels were de...