DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights
To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters. DNA methylation changes in neuroblas...
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| Published in | Epigenomics Vol. 7; no. 7; pp. 1137 - 1153 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.10.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1750-1911 1750-192X |
| DOI | 10.2217/epi.15.49 |
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| Abstract | To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact.
Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters.
DNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as
. Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as
.
This epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor. |
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| AbstractList | AIMTo define the DNA methylation landscape of neuroblastoma and its clinicopathological impact.MATERIALS & METHODSMicroarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters.RESULTSDNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as CCND1. Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as ALK.CONCLUSIONThis epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor. Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Materials & methods: Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters. Results: DNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as CCND1. Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as ALK. Conclusion: This epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor. To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters. DNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as CCND1. Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as ALK. This epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor. To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters. DNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as . Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as . This epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor. |
| Author | Loring, Jeanne F Lemos, Isadora Suñol, Mariona Nazor, Kristopher L Queiros, Ana Mora, Jaume de Torres, Carmen Mayol, Gemma Gómez, Soledad Rodríguez, Eva Bibikova, Marina Lavarino, Cinzia Castellano, Giancarlo Martín-Subero, José I |
| AuthorAffiliation | 1Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Edificio Docente 4th floor, C/Santa Rosa 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain 3Department of Pathology, Hospital Sant Joan de Déu, Barcelona, 08950, Spain 6Department of Anatomic Pathology, Pharmacology & Microbiology, University of Barcelona, Barcelona, 08036, Spain 2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain 4Illumina, Inc., San Diego, CA 92122, USA 5Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA |
| AuthorAffiliation_xml | – name: 1Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Edificio Docente 4th floor, C/Santa Rosa 39-57, 08950 Esplugues de Llobregat, Barcelona, Spain – name: 5Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA – name: 2Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain – name: 3Department of Pathology, Hospital Sant Joan de Déu, Barcelona, 08950, Spain – name: 6Department of Anatomic Pathology, Pharmacology & Microbiology, University of Barcelona, Barcelona, 08036, Spain – name: 4Illumina, Inc., San Diego, CA 92122, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26067621$$D View this record in MEDLINE/PubMed |
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| Copyright | Cinzia Lavarino 2015. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | ALK DNA methylome development CCND1 nonpromoter methylation neuroblastoma non-CpG sites |
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| Snippet | To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact.
Microarray DNA methylation data were analyzed and associated with... Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Materials & methods: Microarray DNA methylation data were... AIMTo define the DNA methylation landscape of neuroblastoma and its clinicopathological impact.MATERIALS & METHODSMicroarray DNA methylation data were analyzed... |
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| SubjectTerms | Adrenal glands Annotations Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - mortality Cell Line, Tumor Child Child, Preschool Chromatin Chromatin - chemistry Chromatin - metabolism Cluster analysis CpG Islands Cyclin D1 - genetics Cyclin D1 - metabolism Cytosine Deoxyribonucleic acid development DNA DNA Fingerprinting DNA Methylation DNA methylome DNA microarrays DNA, Intergenic Domains Epigenesis, Genetic Female Fingerprints Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genome, Human Genomes Guanine Humans Infant Kinases Male Mutation Neuroblastoma Neuroblastoma - diagnosis Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - mortality non-CpG sites nonpromoter methylation Oligonucleotide Array Sequence Analysis Pathogenesis Prognosis Promoter Regions, Genetic Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Stem cells Survival Analysis Transcription Tumors |
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| Title | DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights |
| URI | http://dx.doi.org/10.2217/epi.15.49 https://www.ncbi.nlm.nih.gov/pubmed/26067621 https://www.proquest.com/docview/2291479478 https://www.proquest.com/docview/1749610360 |
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