Inhibition of BMP2 and BMP4 Represses Barrett’s Esophagus While Enhancing the Regeneration of Squamous Epithelium in Preclinical Models

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 15; no. 5; pp. 1199 - 1217
• Main Authors: Correia, Ana C.P., Straub, Danielle, Read, Matthew, Hoefnagel, Sanne J.M., Romero-Pinedo, Salvador, Abadía-Molina, Ana C., Clemons, Nicholas J., Wang, Kenneth, Calpe, Silvia, Phillips, Wayne, Krishnadath, Kausilia K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023; Elsevier
• Subjects: Adenocarcinoma - pathology; Animals; Barrett Esophagus - drug therapy; Barrett Esophagus - pathology; Barrett’s Esophagus; BMP2; BMP4; Bone Morphogenetic Protein 4 - metabolism; Carcinoma, Squamous Cell - pathology; Epithelium - pathology; Hedgehog Proteins - metabolism; Llama-Derived Single-Domain Antibody; Mice; Original Research; Preclinical Models; Targeted Therapy; Barrett’s Esophagus; BE; BMP; EAC; PPI; Preclinical Models; DGERD; Targeted Therapy; BMP4; GFP; BMP2; SHH; TGF-β; SCJ; Llama-Derived Single-Domain Antibody; PCR; SQ

Barrett’s esophagus is considered to be a metaplastic lesion that predisposes for esophageal adenocarcinoma. Development of Barrett’s esophagus is considered to be driven by sonic hedgehog mediated bone morphogenetic protein (BMP) signaling. We aimed to investigate in preclinical in vivo models whet...