Transgelin 2 is required for embryo implantation by promoting actin polymerization

• Published in: The FASEB journal Vol. 33; no. 4; p. 5667
• Main Authors: Liang, Xiaoling, Jin, Yimei, Wang, Hao, Meng, Xinlu, Tan, Zhongzhou, Huang, Tao, Fan, Shangrong
• Format: Journal Article
• Language: English
• Published: United States 01.04.2019
• Subjects: Actins - metabolism; Animals; Blastocyst - metabolism; Cell Line; Embryo Implantation - physiology; Endometrium - metabolism; Female; Humans; Male; Mice; Mice, Inbred ICR; Microfilament Proteins - metabolism; Muscle Proteins - metabolism; NIH 3T3 Cells; Polymerization; Signal Transduction - physiology; Trophoblasts - metabolism; Uterus - metabolism; cell migration; TAGLN2; cell invasion; blastocyst implantation

Infertility has been a great challenge in reproductive medicine. At least 40% of human pregnancy losses are clinically unrecognized and occur because of embryo implantation failure. Identification of the proteins and biochemical factors involved in embryo implantation and that are essential for cros...