Circulating Blood Endothelial Nitric Oxide Synthase Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 33; no. 8; pp. 1861 - 1871
• Main Authors: Wood, Katherine C., Cortese-Krott, Miriam M., Kovacic, Jason C., Noguchi, Audrey, Liu, Virginia B., Wang, Xunde, Raghavachari, Nalini, Boehm, Manfred, Kato, Gregory J., Kelm, Malte, Gladwin, Mark T.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.08.2013
• Subjects: Animals; Arginine - blood; Arginine - pharmacokinetics; Blood Pressure - physiology; Carbon Radioisotopes; Citrulline - blood; Citrulline - pharmacokinetics; Endothelium, Vascular - enzymology; Enzyme Inhibitors - pharmacology; Erythrocytes - enzymology; Homeostasis - physiology; Hypertension - genetics; Hypertension - metabolism; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide - blood; Nitric Oxide Synthase Type III - antagonists & inhibitors; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Nitrites - blood; Signal Transduction - physiology; blood pressure; bone marrow transplant; nitric oxide synthase; blood

OBJECTIVE—Mice genetically deficient in endothelial nitric oxide synthase (eNOS) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. Although the current paradigm holds...