Apoptosis initiated by dependence receptors: a new paradigm for cell death?

• Published in: BioEssays Vol. 26; no. 6; pp. 656 - 664
• Main Authors: Porter, Alan G., Dhakshinamoorthy, Saravanakumar
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2004
• Subjects: Animals; Apoptosis; Caspases - metabolism; Cell Death; Cytoplasm - metabolism; Humans; Ligands; Phenotype; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface - metabolism

A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand‐dependent neuronal growth and differentiation or axon guidance. Acting as “dependence receptors”, they may also regulate neuronal cell survival by inducing apoptosis in the absence of cognate ligand. Recep...