Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans

• Published in: Neurogastroenterology and motility Vol. 24; no. 9; pp. 844 - 852
• Main Authors: Grover, M., Bernard, C. E., Pasricha, P. J., Parkman, H. P., Abell, T. L., Nguyen, L. A., Snape, W., Shen, K. R., Sarr, M., Swain, J., Kendrick, M., Gibbons, S., Ordog, T., Farrugia, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012
• Subjects: Adult; Antibodies; Biopsy; Case-Control Studies; Cell body; Cytology; Diabetes Complications - metabolism; Diabetes mellitus; Enteric nervous system; Female; fibroblast-like cells; Ganglia; Gastric Emptying; gastroparesis; Gastroparesis - metabolism; Humans; Immunohistochemistry; Interstitial cells; interstitial cells of Cajal; Male; Muscle, Smooth - cytology; Muscle, Smooth - metabolism; myenteric plexus; Myenteric Plexus - metabolism; Nervous system; platelet-derived growth factor receptor; Platelet-derived growth factor receptors; Potassium channels (calcium-gated); Receptor, Platelet-Derived Growth Factor alpha - metabolism; Small-Conductance Calcium-Activated Potassium Channels - metabolism; Smooth muscle; Stomach - cytology; Stomach - metabolism

Background  Emerging evidence suggests that “fibroblast‐like cells” (FLC) may play a role in the regulation of gastrointestinal (GI) motor function. FLC are ultrastructurally distinct from other interstitial cells, including interstitial cells of Cajal (ICC), and express small‐conductance Ca2+‐activ...