Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke

• Published in: Journal of inflammation research Vol. 15; pp. 2649 - 2663
• Main Authors: Pu, Zhijun, Bao, Xinyu, Xia, Shengnan, Shao, Pengfei, Xu, Yun
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 30.04.2022; Dove; Dove Medical Press
• Subjects: Analysis; dauricine; Ethylenediaminetetraacetic acid; Ischemia; ischemia–reperfusion injury; Neurons; neutrophil recruitment; Original Research; Permeability; RNA sequencing; serpine1; China; serpine1; dauricine; neutrophil recruitment; ischemia–reperfusion injury

Peripheral neutrophil infiltration can exacerbate ischemia-reperfusion injury. We focused on the relationship between various peripheral immune cells and cerebral ischemia-reperfusion (I/R) injury. In this study, we investigated the effects of dauricine on neuronal injury induced by ischemia-reperfu...