Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitis
Summary Background Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective. Objectives To test the effec...
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Published in | British journal of dermatology (1951) Vol. 148; no. 2; pp. 307 - 313 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.02.2003
Blackwell Oxford University Press |
Subjects | |
Online Access | Get full text |
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Abstract | Summary Background Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective.
Objectives To test the effectiveness of ABT for the symptomatic treatment of patients with AD.
Methods Fifty subjects responded to press advertisements, and 31 were randomized within strata of severity at recruitment. Patients were included into a double‐blind, placebo‐controlled trial and received ABT or placebo once weekly for 5 weeks. Assessments were performed at baseline, at weekly intervals and after a 5‐week follow up. The Six Area, Six Sign AD (SASSAD) severity index was predefined as the primary outcome measure. The Dermatology Life Quality Index and patient ratings of pruritus, quality of sleep and skin appearance on 100‐mm visual analogue scales were defined as secondary outcome measures. Success of patient blinding and adverse events were assessed.
Results Data were analysed on an intention‐to‐treat basis. Analysis of covariance suggested a significant differential change of the SASSAD score between baseline and the end of the follow‐up period in favour of ABT. The mean reduction in SASSAD score was 13·5 points (95% confidence interval, CI 6·6–20·4, P < 0·001) over and above placebo; the corresponding value at the end of treatment was 9·6 (95% CI 4·2–14·9, P = 0·001). No clear significant intergroup differences in any of the secondary outcome measures were found. Six patients in the ABT group and seven in the placebo group reported minor and transient adverse events.
Conclusions These data suggest that, according to the SASSAD score, ABT has beneficial effects in the treatment of AD, although this was not confirmed by the patient‐rated assessments. The improvement in observer‐rated skin condition suggested by this study needs confirmation in larger trials. |
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AbstractList | Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective.
To test the effectiveness of ABT for the symptomatic treatment of patients with AD.
Fifty subjects responded to press advertisements, and 31 were randomized within strata of severity at recruitment. Patients were included into a double-blind, placebo-controlled trial and received ABT or placebo once weekly for 5 weeks. Assessments were performed at baseline, at weekly intervals and after a 5-week follow up. The Six Area, Six Sign AD (SASSAD) severity index was predefined as the primary outcome measure. The Dermatology Life Quality Index and patient ratings of pruritus, quality of sleep and skin appearance on 100-mm visual analogue scales were defined as secondary outcome measures. Success of patient blinding and adverse events were assessed.
Data were analysed on an intention-to-treat basis. Analysis of covariance suggested a significant differential change of the SASSAD score between baseline and the end of the follow-up period in favour of ABT. The mean reduction in SASSAD score was 13.5 points (95% confidence interval, CI 6.6-20.4, P < 0.001) over and above placebo; the corresponding value at the end of treatment was 9.6 (95% CI 4.2-14.9, P = 0.001). No clear significant intergroup differences in any of the secondary outcome measures were found. Six patients in the ABT group and seven in the placebo group reported minor and transient adverse events.
These data suggest that, according to the SASSAD score, ABT has beneficial effects in the treatment of AD, although this was not confirmed by the patient-rated assessments. The improvement in observer-rated skin condition suggested by this study needs confirmation in larger trials. BACKGROUNDAutologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective.OBJECTIVESTo test the effectiveness of ABT for the symptomatic treatment of patients with AD.METHODSFifty subjects responded to press advertisements, and 31 were randomized within strata of severity at recruitment. Patients were included into a double-blind, placebo-controlled trial and received ABT or placebo once weekly for 5 weeks. Assessments were performed at baseline, at weekly intervals and after a 5-week follow up. The Six Area, Six Sign AD (SASSAD) severity index was predefined as the primary outcome measure. The Dermatology Life Quality Index and patient ratings of pruritus, quality of sleep and skin appearance on 100-mm visual analogue scales were defined as secondary outcome measures. Success of patient blinding and adverse events were assessed.RESULTSData were analysed on an intention-to-treat basis. Analysis of covariance suggested a significant differential change of the SASSAD score between baseline and the end of the follow-up period in favour of ABT. The mean reduction in SASSAD score was 13.5 points (95% confidence interval, CI 6.6-20.4, P < 0.001) over and above placebo; the corresponding value at the end of treatment was 9.6 (95% CI 4.2-14.9, P = 0.001). No clear significant intergroup differences in any of the secondary outcome measures were found. Six patients in the ABT group and seven in the placebo group reported minor and transient adverse events.CONCLUSIONSThese data suggest that, according to the SASSAD score, ABT has beneficial effects in the treatment of AD, although this was not confirmed by the patient-rated assessments. The improvement in observer-rated skin condition suggested by this study needs confirmation in larger trials. Summary Background Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition. However, there is little evidence from rigorous clinical trials to suggest that it is effective. Objectives To test the effectiveness of ABT for the symptomatic treatment of patients with AD. Methods Fifty subjects responded to press advertisements, and 31 were randomized within strata of severity at recruitment. Patients were included into a double‐blind, placebo‐controlled trial and received ABT or placebo once weekly for 5 weeks. Assessments were performed at baseline, at weekly intervals and after a 5‐week follow up. The Six Area, Six Sign AD (SASSAD) severity index was predefined as the primary outcome measure. The Dermatology Life Quality Index and patient ratings of pruritus, quality of sleep and skin appearance on 100‐mm visual analogue scales were defined as secondary outcome measures. Success of patient blinding and adverse events were assessed. Results Data were analysed on an intention‐to‐treat basis. Analysis of covariance suggested a significant differential change of the SASSAD score between baseline and the end of the follow‐up period in favour of ABT. The mean reduction in SASSAD score was 13·5 points (95% confidence interval, CI 6·6–20·4, P < 0·001) over and above placebo; the corresponding value at the end of treatment was 9·6 (95% CI 4·2–14·9, P = 0·001). No clear significant intergroup differences in any of the secondary outcome measures were found. Six patients in the ABT group and seven in the placebo group reported minor and transient adverse events. Conclusions These data suggest that, according to the SASSAD score, ABT has beneficial effects in the treatment of AD, although this was not confirmed by the patient‐rated assessments. The improvement in observer‐rated skin condition suggested by this study needs confirmation in larger trials. |
Author | Collier, P.M. Armstrong, N.C. Hart, A. Pittler, M.H. Ernst, E. Cox, A. |
Author_xml | – sequence: 1 givenname: M.H. surname: Pittler fullname: Pittler, M.H. organization: Department of Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, U.K – sequence: 2 givenname: N.C. surname: Armstrong fullname: Armstrong, N.C. organization: Eurocat Project, University of Ulster, Newtownabbey, U.K – sequence: 3 givenname: A. surname: Cox fullname: Cox, A. organization: Dermatology Outpatients Clinic, Royal Devon and Exeter NHS Trust, Exeter, U.K – sequence: 4 givenname: P.M. surname: Collier fullname: Collier, P.M. organization: Dermatology Outpatients Clinic, Royal Devon and Exeter NHS Trust, Exeter, U.K – sequence: 5 givenname: A. surname: Hart fullname: Hart, A. organization: Medical Statistics Group, University of Central Lancashire, Preston, U.K – sequence: 6 givenname: E. surname: Ernst fullname: Ernst, E. organization: Department of Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, U.K |
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Cites_doi | 10.1001/archderm.134.11.1462 10.1007/BF02447930 10.1136/bmj.318.7198.1600 10.1136/bmj.315.7110.717 10.1016/S0140-6736(96)91171-X 10.1001/archderm.136.6.763 10.1046/j.1365-2133.1996.d01-970.x 10.2340/00015555924447 10.1016/0140-6736(91)90134-B 10.1016/S0140-6736(00)02529-0 10.1089/acm.1997.3.155 10.1111/j.1365-2133.1993.tb03170.x 10.1111/j.1365-2230.1994.tb01167.x 10.1159/000247298 10.1046/j.1365-2133.2000.03463.x 10.1159/000057140 10.1016/S0140-6736(97)12082-7 10.1046/j.1365-2133.1999.02617.x 10.1111/j.1365-2230.1992.tb00244.x 10.1016/S0190-9622(96)90281-9 10.1136/bmj.321.7255.240 10.1046/j.1365-2133.2001.04077.x 10.1046/j.1365-2133.1996.d01-1061.x |
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Keywords | Human Allergy Immunopathology Skin disease Transfusion Immunomodulation Autologous system Injection Intramuscular administration Blood Atopy randomized controlled trial Treatment dermatology Atopic dermatitis Alternative medicine autologous blood therapy Double blind study eczema |
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References | Herd RM, Tidman MJ, Prescott RJ, Hunter JA. The cost of atopic eczema. Br J Dermatol 1996; 135: 20-3. Webster GJM, Hallett R, Whalley SA et al. Molecular epidemiology of a large outbreak of hepatitis B linked to autohaemaotherapy. Lancet 2000; 356: 379-84. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92 (Suppl.): 44-7. Charman CR. Atopic eczema. Br Med J 1999; 318: 1600-4. Ruzicka T. Atopic eczema between rationality and irrationality. Arch Dermatol 1998; 134: 1462-9. Berth-Jones J. Six area, six sign atopic dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis. Br J Dermatol 1996; 135 (Suppl. 48): 25-30. Olwin JH, Ratajczak HV, House RV. Successful treatment of herpetic infections by autohaemotherapy. J Altern Comp Ther 1997; 3: 155-8. Dehmlow R. Biophysikalische biochemische und immunmodulatorische Überlegungen zur Wirkungsweise verfremdeten Eigenbluts (Autologe Therapien). Erfahrungsheilkunde 2000; 6: 580-90. Daschner FD. Hepatitis C and immunodeficiency virus infection following ozone autohaemotherapy. Eur J Clin Microbiol Infect Dis 1997; 16: 620. Ernst E. The usage of complementary therapies by dermatological patients: a systematic review. Br J Dermatol 2000; 142: 857-61. Rudikoff D, Lebwohl M. Atopic dermatitis. Lancet 1998; 351: 1715-21. Charman CR, Williams HC. Outcome measures of disease severity in atopic eczema. Arch Dermatol 2000; 136: 763-9. Emerson RM, Williams HC, Allen BR. What is the cost of atopic dermatitis in preschool children? Br J Dermatol 2001; 144: 514-22. Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol (Stockh) 1989; 144: 13-14. Hardwick C. The indications for and technique of whole-blood injections. Practitioner 1940; 144: 79-82. European Task Force on Atopic Dermatitis. Severity scoring for atopic dermatitis: the SCORAD index. Dermatology 1993; 186: 23-31. Williams HC. Is the prevalance of atopic dermatitis increasing? Clin Exp Dermatol 1992; 17: 385-91. Schimmel K-C, ed. Lehrbuch der Naturheilverfahren, Band I. Stuttgart: Hippokrates, 1990. Finlay JM, Khan GK. Dermatology Life Quality Index (DLQI) - a simple practical measure for routine clinical use. Clin Exp Dermatol 1994; 19: 210-16. Chopra A, Mamta, Chopra D . Autohaemotherapy in chronic urticaria. Indian J Dermatol Venereol Leprol 1995; 61: 323-4. Berth-Jones J, Finlay AY, Zaki I et al. Cyclosporin in severe childhood atopic dermatitis: a multicenter study. J Am Acad Dermatol 1996; 34: 1016-21. Butland BK, Strachnan DP, Lewis S et al. Investigation into the increase in hayfever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. Br Med J 1997; 315: 717-21. Charman CR, Venn AJ, Williams HC. Measurement of body surface area involvement in atopic eczema: an impossible task? Br J Dermatol 1990; 140: 109-11. Klemparskaya NN, Shalnova GA, Ulanova AM et al. Immunmodulating effects of autohaemotherapy. J Hyg Epidemiol Microbiol Immun 1986; 30: 331-6. Asefi M, Augustin M. Regulationstherapie: Behandlung mit unspezifischen Reizen in der Dermatologie aus traditioneller und moderner Sicht. Forsch Komplementarmed 1999; 6 (Suppl. 2): 9-13. Sowden JM, Berth-Jones J, Ross JS et al. Double-blind controlled crossover study of cyclosporin in adults with severe refractory dermatitis. Lancet 1991; 338: 137-40. Gabriel C, Blauhut B, Greul R et al. Transmission of hepatitis C by ozone enrichment of autologous blood. Lancet 1996; 347: 541. Lapsley P. Management of chronic skin conditions is important. Br Med J 2000; 321: 240. Salek MS, Finlay AY, Luscombe DK et al. Cyclosporin greatly improves the quality of life of adults with severe atopic dermatitis. A randomized, double-blind, placebo-controlled trial. Br J Dermatol 1993; 129: 422-30. 2001; 144 1997; 315 1993; 129 1986; 30 2000; 6 2000; 136 2000; 356 1992; 17 1980; 92 1991; 338 1999; 6 1997; 3 1998; 134 1993; 186 1998; 351 1996; 34 1940; 144 1990; 140 1996; 347 1995; 61 1990 1994; 19 1989; 144 1997; 16 2000; 142 2000; 321 1996; 135 1999; 318 Daschner FD (b27_498) 1997; 16 Klemparskaya NN (b13_484) 1986; 30 Rajka G (b17_488) 1989; 144 b1_472 b7_478 b28_499 Lapsley P (b5_476) 2000; 321 b22_493 b8_479 Olwin JH (b14_485) 1997; 3 Williams HC (b2_473) 1992; 17 Hanifin JM (b16_487) 1980; 92 b19_490 Salek MS (b21_492) 1993; 129 Chopra A (b15_486) 1995; 61 b23_494 Schimmel K-C (b12_483) 1990 Butland BK (b3_474) 1997; 315 Hardwick C (b9_480) 1940; 144 Dehmlow R (b26_497) 2000; 6 European Task Force on Atopic Dermatitis. (b24_495) 1993; 186 b11_482 Finlay JM (b20_491) 1994; 19 b6_477 Charman CR (b4_475) 1999; 318 b25_496 b18_489 Gabriel C (b29_500) 1996; 347 b10_481 |
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A randomized, double‐blind, placebo‐controlled trial publication-title: Br J Dermatol – volume: 6 start-page: 9 issue: Suppl. 2 year: 1999 end-page: 13 article-title: Regulationstherapie: Behandlung mit unspezifischen Reizen in der Dermatologie aus traditioneller und moderner Sicht publication-title: Forsch Komplementarmed – volume: 318 start-page: 1600 year: 1999 end-page: 4 article-title: Atopic eczema publication-title: Br Med J – volume: 30 start-page: 331 year: 1986 end-page: 6 article-title: Immunmodulating effects of autohaemotherapy publication-title: J Hyg Epidemiol Microbiol Immun – volume: 144 start-page: 514 year: 2001 end-page: 22 article-title: What is the cost of atopic dermatitis in preschool children? publication-title: Br J Dermatol – volume: 338 start-page: 137 year: 1991 end-page: 40 article-title: Double‐blind controlled crossover study of cyclosporin in adults with severe refractory dermatitis publication-title: Lancet – volume: 140 start-page: 109 year: 1990 end-page: 11 article-title: Measurement of body surface area involvement in atopic eczema: an impossible task? publication-title: Br J Dermatol – volume: 135 start-page: 20 year: 1996 end-page: 3 article-title: The cost of atopic eczema publication-title: Br J Dermatol – ident: b10_481 doi: 10.1001/archderm.134.11.1462 – volume: 16 start-page: 620 year: 1997 ident: b27_498 publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/BF02447930 contributor: fullname: Daschner FD – volume: 318 start-page: 1600 year: 1999 ident: b4_475 publication-title: Br Med J doi: 10.1136/bmj.318.7198.1600 contributor: fullname: Charman CR – volume: 61 start-page: 323 year: 1995 ident: b15_486 publication-title: Indian J Dermatol Venereol Leprol contributor: fullname: Chopra A – volume: 315 start-page: 717 year: 1997 ident: b3_474 publication-title: Br Med J doi: 10.1136/bmj.315.7110.717 contributor: fullname: Butland BK – volume: 347 start-page: 541 year: 1996 ident: b29_500 publication-title: Lancet doi: 10.1016/S0140-6736(96)91171-X contributor: fullname: Gabriel C – volume-title: Lehrbuch der Naturheilverfahren year: 1990 ident: b12_483 contributor: fullname: Schimmel K-C – ident: b18_489 doi: 10.1001/archderm.136.6.763 – ident: b6_477 doi: 10.1046/j.1365-2133.1996.d01-970.x – volume: 144 start-page: 79 year: 1940 ident: b9_480 publication-title: Practitioner contributor: fullname: Hardwick C – volume: 92 start-page: 44 year: 1980 ident: b16_487 publication-title: Acta Derm Venereol (Stockh) doi: 10.2340/00015555924447 contributor: fullname: Hanifin JM – volume: 144 start-page: 13 year: 1989 ident: b17_488 publication-title: Acta Derm Venereol (Stockh) contributor: fullname: Rajka G – ident: b22_493 doi: 10.1016/0140-6736(91)90134-B – ident: b28_499 doi: 10.1016/S0140-6736(00)02529-0 – volume: 6 start-page: 580 year: 2000 ident: b26_497 publication-title: Erfahrungsheilkunde contributor: fullname: Dehmlow R – volume: 3 start-page: 155 year: 1997 ident: b14_485 publication-title: J Altern Comp Ther doi: 10.1089/acm.1997.3.155 contributor: fullname: Olwin JH – volume: 129 start-page: 422 year: 1993 ident: b21_492 publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.1993.tb03170.x contributor: fullname: Salek MS – volume: 19 start-page: 210 year: 1994 ident: b20_491 publication-title: Clin Exp Dermatol doi: 10.1111/j.1365-2230.1994.tb01167.x contributor: fullname: Finlay JM – volume: 186 start-page: 23 year: 1993 ident: b24_495 publication-title: Dermatology doi: 10.1159/000247298 contributor: fullname: European Task Force on Atopic Dermatitis. – ident: b8_479 doi: 10.1046/j.1365-2133.2000.03463.x – ident: b11_482 doi: 10.1159/000057140 – ident: b1_472 doi: 10.1016/S0140-6736(97)12082-7 – ident: b25_496 doi: 10.1046/j.1365-2133.1999.02617.x – volume: 17 start-page: 385 year: 1992 ident: b2_473 publication-title: Clin Exp Dermatol doi: 10.1111/j.1365-2230.1992.tb00244.x contributor: fullname: Williams HC – ident: b23_494 doi: 10.1016/S0190-9622(96)90281-9 – volume: 321 start-page: 240 year: 2000 ident: b5_476 publication-title: Br Med J doi: 10.1136/bmj.321.7255.240 contributor: fullname: Lapsley P – ident: b7_478 doi: 10.1046/j.1365-2133.2001.04077.x – ident: b19_490 doi: 10.1046/j.1365-2133.1996.d01-1061.x – volume: 30 start-page: 331 year: 1986 ident: b13_484 publication-title: J Hyg Epidemiol Microbiol Immun contributor: fullname: Klemparskaya NN |
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Snippet | Summary Background Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for... Autologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this condition.... BACKGROUNDAutologous blood therapy (ABT) is used for treating atopic dermatitis (AD) in some European countries and is promoted on internet sites for this... |
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SubjectTerms | Adult Allergic diseases alternative medicine atopic dermatitis autologous blood therapy Biological and medical sciences Blood Transfusion, Autologous - methods Dermatitis, Atopic - complications Dermatitis, Atopic - therapy dermatology Double-Blind Method eczema Female Humans Immunopathology Male Medical sciences Pruritus - complications Quality of Life randomized controlled trial Severity of Illness Index Skin allergic diseases. Stinging insect allergies Sleep Treatment Outcome |
Title | Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitis |
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