Encapsulation of protein microfiber networks supporting pancreatic islets
Networks of discrete, genipin‐crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vort...
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| Published in | Journal of biomedical materials research. Part A Vol. 100A; no. 12; pp. 3384 - 3391 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.12.2012
Wiley-Blackwell Wiley Subscription Services, Inc |
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| Online Access | Get full text |
| ISSN | 1549-3296 1552-4965 1552-4965 |
| DOI | 10.1002/jbm.a.34281 |
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| Abstract | Networks of discrete, genipin‐crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vortex‐drawn extrusion within an alginate support matrix. Optimization culminated in a hydrated fiber diameter of 22.3 ± 0.4 μm, a significant reduction relative to that available through current gelatin microfiber spinning techniques, while making the process more reliable and less labor intensive. Microfibers were encapsulated at 40 vol % within 294 ± 4 μm 1.6% barium alginate microparticles by electrostatic‐mediated dropwise extrusion. Pancreatic islets extracted from Sprague Dawley rats were encapsulated within the microparticles and analyzed over 21 days. Acridine orange and propidium iodide fluorescent viability staining and light microscopy indicated a significant increase in viability for islets within the fiber‐embedded particles relative to fiber‐free controls at days 7, 14, and 21. The fiber‐embedded system also promoted cellular aggregate cohesion, reducing the incidence of dispersed islet morphologies within the capsules from 31 to 8% at day 21. Further enquiry into benefits of islet encapsulation within a protein fiber network will be the subject of future investigation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3384–3391, 2012. |
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| AbstractList | Networks of discrete, genipin‐crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vortex‐drawn extrusion within an alginate support matrix. Optimization culminated in a hydrated fiber diameter of 22.3 ± 0.4 μm, a significant reduction relative to that available through current gelatin microfiber spinning techniques, while making the process more reliable and less labor intensive. Microfibers were encapsulated at 40 vol % within 294 ± 4 μm 1.6% barium alginate microparticles by electrostatic‐mediated dropwise extrusion. Pancreatic islets extracted from Sprague Dawley rats were encapsulated within the microparticles and analyzed over 21 days. Acridine orange and propidium iodide fluorescent viability staining and light microscopy indicated a significant increase in viability for islets within the fiber‐embedded particles relative to fiber‐free controls at days 7, 14, and 21. The fiber‐embedded system also promoted cellular aggregate cohesion, reducing the incidence of dispersed islet morphologies within the capsules from 31 to 8% at day 21. Further enquiry into benefits of islet encapsulation within a protein fiber network will be the subject of future investigation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:3384–3391, 2012. Networks of discrete, genipin-crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vortex-drawn extrusion within an alginate support matrix. Optimization culminated in a hydrated fiber diameter of 22.3 ± 0.4 μm, a significant reduction relative to that available through current gelatin microfiber spinning techniques, while making the process more reliable and less labor intensive. Microfibers were encapsulated at 40 vol % within 294 ± 4 μm 1.6% barium alginate microparticles by electrostatic-mediated dropwise extrusion. Pancreatic islets extracted from Sprague Dawley rats were encapsulated within the microparticles and analyzed over 21 days. Acridine orange and propidium iodide fluorescent viability staining and light microscopy indicated a significant increase in viability for islets within the fiber-embedded particles relative to fiber-free controls at days 7, 14, and 21. The fiber-embedded system also promoted cellular aggregate cohesion, reducing the incidence of dispersed islet morphologies within the capsules from 31 to 8% at day 21. Further enquiry into benefits of islet encapsulation within a protein fiber network will be the subject of future investigation. Networks of discrete, genipin-crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vortex-drawn extrusion within an alginate support matrix. Optimization culminated in a hydrated fiber diameter of 22.3 ± 0.4 μm, a significant reduction relative to that available through current gelatin microfiber spinning techniques, while making the process more reliable and less labor intensive. Microfibers were encapsulated at 40 vol % within 294 ± 4 μm 1.6% barium alginate microparticles by electrostatic-mediated dropwise extrusion. Pancreatic islets extracted from Sprague Dawley rats were encapsulated within the microparticles and analyzed over 21 days. Acridine orange and propidium iodide fluorescent viability staining and light microscopy indicated a significant increase in viability for islets within the fiber-embedded particles relative to fiber-free controls at days 7, 14, and 21. The fiber-embedded system also promoted cellular aggregate cohesion, reducing the incidence of dispersed islet morphologies within the capsules from 31 to 8% at day 21. Further enquiry into benefits of islet encapsulation within a protein fiber network will be the subject of future investigation.Networks of discrete, genipin-crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel technique enabled encapsulation of cellular aggregates in a spherical fibrous matrix <300 μm in diameter. Microfibers were produced by vortex-drawn extrusion within an alginate support matrix. Optimization culminated in a hydrated fiber diameter of 22.3 ± 0.4 μm, a significant reduction relative to that available through current gelatin microfiber spinning techniques, while making the process more reliable and less labor intensive. Microfibers were encapsulated at 40 vol % within 294 ± 4 μm 1.6% barium alginate microparticles by electrostatic-mediated dropwise extrusion. Pancreatic islets extracted from Sprague Dawley rats were encapsulated within the microparticles and analyzed over 21 days. Acridine orange and propidium iodide fluorescent viability staining and light microscopy indicated a significant increase in viability for islets within the fiber-embedded particles relative to fiber-free controls at days 7, 14, and 21. The fiber-embedded system also promoted cellular aggregate cohesion, reducing the incidence of dispersed islet morphologies within the capsules from 31 to 8% at day 21. Further enquiry into benefits of islet encapsulation within a protein fiber network will be the subject of future investigation. |
| Author | Barron, Annelise E. Carmona, Euridice Steele, Joseph A. M. Neufeld, Ronald J. Hallé, Jean-Pierre |
| Author_xml | – sequence: 1 givenname: Joseph A. M. surname: Steele fullname: Steele, Joseph A. M. organization: Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada, K7L 3N6 – sequence: 2 givenname: Annelise E. surname: Barron fullname: Barron, Annelise E. organization: Department of Bioengineering, Stanford University, Stanford, California 94305-5444 – sequence: 3 givenname: Euridice surname: Carmona fullname: Carmona, Euridice organization: Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada, H1T 2M4 – sequence: 4 givenname: Jean-Pierre surname: Hallé fullname: Hallé, Jean-Pierre organization: Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada, H1T 2M4 – sequence: 5 givenname: Ronald J. surname: Neufeld fullname: Neufeld, Ronald J. email: neufeld@queensu.ca organization: Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada, K7L 3N6 |
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| CitedBy_id | crossref_primary_10_1007_s11892_017_0877_0 crossref_primary_10_1016_j_bcp_2015_08_107 crossref_primary_10_1177_2041731419884708 crossref_primary_10_1016_j_addr_2013_07_010 crossref_primary_10_1088_2053_1591_aaaedc crossref_primary_10_1007_s11427_014_4609_2 crossref_primary_10_1016_j_addr_2013_09_015 crossref_primary_10_1186_s13287_018_1130_8 |
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| Keywords | Encapsulation Tissue engineering Biomaterial Scaffold Pancreas Protein pancreatic islets Biomedical engineering microfibers |
| Language | English |
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| Notes | How to cite this article: Steele JAM, Barron AE, Carmona E, Hallé J-P, Neufeld RJ. 2012. Encapsulation of protein microfiber networks supporting pancreatic islets. J Biomed Mater Res Part A 2012:100A:3384-3391. ark:/67375/WNG-RT1QV82D-B istex:1801EA4F9EB913B5EF61FBCD18A2EFAE25F4DDE4 ArticleID:JBM34281 Steele JAM, Barron AE, Carmona E, Hallé J‐P, Neufeld RJ. 2012. Encapsulation of protein microfiber networks supporting pancreatic islets. J Biomed Mater Res Part A 2012:100A:3384–3391. How to cite this article ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| Snippet | Networks of discrete, genipin‐crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel... Networks of discrete, genipin-crosslinked gelatin microfibers enveloping pancreatic islets were incorporated within barium alginate microcapsules. This novel... |
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| SubjectTerms | Acridine orange Adhesiveness Alginates Alginic acid Animals Barium Biological and medical sciences Biotechnology Capsules - chemistry Cross-Linking Reagents - pharmacology Crosslinking Embedded systems Encapsulation Extrusion Fluorescence Fundamental and applied biological sciences. Psychology Gelatin Gelatin - metabolism Genipin Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Iodides Iridoids - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - physiology Light microscopy Male Medical sciences Microcapsules Microencapsulation Microfibers Microparticles Microscopy, Electron, Scanning Miscellaneous Morphology Optical microscopy Optimization Pancreas pancreatic islets Propidium iodide Proteins Rats Rats, Sprague-Dawley scaffold Static Electricity Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tissue engineering Tissue Survival - drug effects |
| Title | Encapsulation of protein microfiber networks supporting pancreatic islets |
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