Widespread expression of parathyroid hormone-related peptide in melanocytic cells
Summary Background Parathyroid hormone‐related peptide (PTH‐rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH‐rP could occur in patients with advanced melanoma. Objectives We examined PTH‐rP expression in cultured melanocytic cell lines and in lesi...
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Published in | British journal of dermatology (1951) Vol. 148; no. 3; pp. 533 - 538 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Science Ltd
01.03.2003
Blackwell Oxford University Press |
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Abstract | Summary Background Parathyroid hormone‐related peptide (PTH‐rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH‐rP could occur in patients with advanced melanoma.
Objectives We examined PTH‐rP expression in cultured melanocytic cell lines and in lesions of melanocytic origin for associations with clinicopathological variables of disease progression. We measured the supernatant and cell lysate level of PTH‐rP in cultured melanoma cells to clarify whether melanoma cells secrete PTH‐rP.
Methods PTH‐rP expression was examined by reverse transcriptase–polymerase chain reaction (RT–PCR) in cultured melanocytic cell lines and by immunoperoxidase staining in 18 melanocytic naevi, 40 primary melanoma and 19 metastatic melanoma lesions. The supernatant level of PTH‐rP was measured with an immunoradiometric assay.
Results RT–PCR products of PTH‐rP mRNA were detected in six of eight melanoma cell lines; however, neither naevus cells nor melanocytes showed positive products. On the other hand, immunohistochemical analysis showed that PTH‐rP was widely expressed both in benign and malignant melanocytic lesions. In addition, PTH‐rP expression was not associated with any clinicopathological variables. Cell lysate but not the supernatant of melanoma cells showed high PTH‐rP levels.
Conclusions These results suggest that PTH‐rP was widely expressed in melanocytic cells; however, the cells did not secrete PTH‐rP. |
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AbstractList | Parathyroid hormone-related peptide (PTH-rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH-rP could occur in patients with advanced melanoma.
We examined PTH-rP expression in cultured melanocytic cell lines and in lesions of melanocytic origin for associations with clinicopathological variables of disease progression. We measured the supernatant and cell lysate level of PTH-rP in cultured melanoma cells to clarify whether melanoma cells secrete PTH-rP.
PTH-rP expression was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) in cultured melanocytic cell lines and by immunoperoxidase staining in 18 melanocytic naevi, 40 primary melanoma and 19 metastatic melanoma lesions. The supernatant level of PTH-rP was measured with an immunoradiometric assay.
RT-PCR products of PTH-rP mRNA were detected in six of eight melanoma cell lines; however, neither naevus cells nor melanocytes showed positive products. On the other hand, immunohistochemical analysis showed that PTH-rP was widely expressed both in benign and malignant melanocytic lesions. In addition, PTH-rP expression was not associated with any clinicopathological variables. Cell lysate but not the supernatant of melanoma cells showed high PTH-rP levels.
These results suggest that PTH-rP was widely expressed in melanocytic cells; however, the cells did not secrete PTH-rP. Summary Background Parathyroid hormone‐related peptide (PTH‐rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH‐rP could occur in patients with advanced melanoma. Objectives We examined PTH‐rP expression in cultured melanocytic cell lines and in lesions of melanocytic origin for associations with clinicopathological variables of disease progression. We measured the supernatant and cell lysate level of PTH‐rP in cultured melanoma cells to clarify whether melanoma cells secrete PTH‐rP. Methods PTH‐rP expression was examined by reverse transcriptase–polymerase chain reaction (RT–PCR) in cultured melanocytic cell lines and by immunoperoxidase staining in 18 melanocytic naevi, 40 primary melanoma and 19 metastatic melanoma lesions. The supernatant level of PTH‐rP was measured with an immunoradiometric assay. Results RT–PCR products of PTH‐rP mRNA were detected in six of eight melanoma cell lines; however, neither naevus cells nor melanocytes showed positive products. On the other hand, immunohistochemical analysis showed that PTH‐rP was widely expressed both in benign and malignant melanocytic lesions. In addition, PTH‐rP expression was not associated with any clinicopathological variables. Cell lysate but not the supernatant of melanoma cells showed high PTH‐rP levels. Conclusions These results suggest that PTH‐rP was widely expressed in melanocytic cells; however, the cells did not secrete PTH‐rP. BACKGROUNDParathyroid hormone-related peptide (PTH-rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH-rP could occur in patients with advanced melanoma.OBJECTIVESWe examined PTH-rP expression in cultured melanocytic cell lines and in lesions of melanocytic origin for associations with clinicopathological variables of disease progression. We measured the supernatant and cell lysate level of PTH-rP in cultured melanoma cells to clarify whether melanoma cells secrete PTH-rP.METHODSPTH-rP expression was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) in cultured melanocytic cell lines and by immunoperoxidase staining in 18 melanocytic naevi, 40 primary melanoma and 19 metastatic melanoma lesions. The supernatant level of PTH-rP was measured with an immunoradiometric assay.RESULTSRT-PCR products of PTH-rP mRNA were detected in six of eight melanoma cell lines; however, neither naevus cells nor melanocytes showed positive products. On the other hand, immunohistochemical analysis showed that PTH-rP was widely expressed both in benign and malignant melanocytic lesions. In addition, PTH-rP expression was not associated with any clinicopathological variables. Cell lysate but not the supernatant of melanoma cells showed high PTH-rP levels.CONCLUSIONSThese results suggest that PTH-rP was widely expressed in melanocytic cells; however, the cells did not secrete PTH-rP. |
Author | Ichihashi, M. Funasaka, Y. Dong, J. Ishihara, T. Ono, T. Tokuo, H. Kageshita, T. Nakajima, M. |
Author_xml | – sequence: 1 givenname: T. surname: Kageshita fullname: Kageshita, T. organization: Department of Dermatology, Kumamoto University School of Medicine, 1-1 Honjo, Kumamoto 860-0811, Japan – sequence: 2 givenname: T. surname: Ishihara fullname: Ishihara, T. organization: Department of Dermatology, Kumamoto University School of Medicine, 1-1 Honjo, Kumamoto 860-0811, Japan – sequence: 3 givenname: H. surname: Tokuo fullname: Tokuo, H. organization: Department of Dermatology, Kumamoto University School of Medicine, 1-1 Honjo, Kumamoto 860-0811, Japan – sequence: 4 givenname: Y. surname: Funasaka fullname: Funasaka, Y. organization: Department of Dermatology, Kobe University School of Medicine, Kobe, Japan – sequence: 5 givenname: M. surname: Ichihashi fullname: Ichihashi, M. organization: Department of Dermatology, Kobe University School of Medicine, Kobe, Japan – sequence: 6 givenname: J. surname: Dong fullname: Dong, J. organization: Division of Research, Tsukuba Research Institute, Novartis Pharma K.K., Tsukuba, Japan – sequence: 7 givenname: M. surname: Nakajima fullname: Nakajima, M. organization: Division of Research, Tsukuba Research Institute, Novartis Pharma K.K., Tsukuba, Japan – sequence: 8 givenname: T. surname: Ono fullname: Ono, T. organization: Department of Dermatology, Kumamoto University School of Medicine, 1-1 Honjo, Kumamoto 860-0811, Japan |
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Keywords | Human Cell culture parathyroid hormone-related peptide Melanocyte Malignant melanoma Parathyroid hormone related peptide disease progression |
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References_xml | – volume: 187 start-page: 217 year: 1999 end-page: 22 article-title: Clinicopathological implications of parathyroid hormone‐related protein in human colorectal tumors publication-title: J Pathol – volume: 128 start-page: 278 year: 1992 end-page: 9 article-title: Parathyroid hormone‐related protein in patients with malignant melanoma publication-title: Arch Dermatol – volume: 41 start-page: 397 year: 2001 end-page: 409 article-title: Expression and in vitro modification of parathyroid hormone‐related protein (PTHrP) and PTH/PTHrP‐receptor in human myeloma cells publication-title: Leukemia Lymphoma – volume: 29 start-page: 629 year: 2000 end-page: 45 article-title: The parathyroid hormone‐related protein publication-title: Endocrinol Metab Clinics North Am – volume: 279 start-page: C1230 year: 2000 end-page: 38 article-title: Expression and regulation of parathyroid hormone‐related peptide in normal and malignant melanocytes publication-title: Am J Cell Physiol – volume: 158 start-page: 293 year: 1989 end-page: 6 article-title: Expression of parathyroid hormone related protein in normal skin and in tumours of skin and skin appendages publication-title: J Pathol – volume: 67 start-page: 680 year: 1992 end-page: 702 article-title: Mechanisms of cancer‐induced hypercalcemia publication-title: Lab Invest – start-page: 143 year: 1992 end-page: 8 – volume: 87 start-page: 95 year: 1986 end-page: 101 article-title: Human melanocytes cultured from nevi and melanomas publication-title: J Invest Dermatol – volume: 51 start-page: 167 year: 1980 end-page: 9 article-title: Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer publication-title: J Clin Endocrinol Metab – volume: 197 start-page: 65 year: 1998 end-page: 8 article-title: Hypercalcemia in a patients with malignant melanoma arising in congenital giant pigmented nevus. A case of increased serum level of parathyroid hormone‐related protein publication-title: Dermatology – volume: 3 start-page: 197 year: 1992 end-page: 209 article-title: C‐kit‐kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen‐activated protein kinase but is down‐regulated in melanoma publication-title: Mol Biol Cell – volume: 139 start-page: 423 year: 1991 end-page: 35 article-title: Cell migration and actin organization in cultured human primary, recurrent cutaneous and metastatic melanoma. Time‐lapse and image analysis publication-title: Am J Pathol – volume: 91 start-page: 8014 year: 1994 end-page: 16 article-title: A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice publication-title: Proc Natl Acad Sci USA – volume: 49 start-page: 288 year: 1998 end-page: 91 article-title: Hypercalcemia due to parathyroid hormone‐related protein secretion by melanoma publication-title: Horm Res – volume: 4 start-page: 273 year: 1989 end-page: 8 article-title: Parathyroid hormone‐related protein. 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Snippet | Summary Background Parathyroid hormone‐related peptide (PTH‐rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of... Parathyroid hormone-related peptide (PTH-rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH-rP could occur... BACKGROUNDParathyroid hormone-related peptide (PTH-rP) was associated with the syndrome of hypercalcaemia of malignancy. An increased serum level of PTH-rP... |
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SubjectTerms | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Dermatology disease progression Female Humans Immunohistochemistry - methods Investigative techniques, diagnostic techniques (general aspects) Male malignant melanoma Medical sciences Melanocytes - metabolism Melanoma - metabolism Middle Aged Nevus - metabolism parathyroid hormone-related peptide Parathyroid Hormone-Related Protein Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptide Hormones - analysis Peptide Hormones - blood Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - analysis Skin Neoplasms - metabolism Tumor Cells, Cultured |
Title | Widespread expression of parathyroid hormone-related peptide in melanocytic cells |
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