Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor - Zhu, Liping; Xiao, Rui; Zhang, Xiuyun; Lang, Yuheng; Liu, Fangbo; Yu, Zhe; Zhang, Jiwei; Su, Yuan; Lu, Yankai; Wang, Tao; Luo, Shengquan; Wang, Jian; et al. (Arteriosclerosis, thrombosis, and vascular biology, 2019)
Keywords: Animals; Benzamides - pharmacology; Biological Transport; Calcium - physiology; Calcium Signaling - drug effects; Calcium Signaling - physiology; Cyclohexylamines - pharmacology; Endothelial Cells - metabolism; Endothelium, Vascular - metabolism; Extracellular Vesicles - chemistry; Extracellular Vesicles - physiology; Gene Knockdown Techniques; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - physiopathology; Hypertension, Pulmonary - prevention & control; Male; Myocytes, Smooth Muscle - metabolism; Pulmonary Artery - drug effects; Pulmonary Artery - metabolism; Pulmonary Artery - pathology; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing - antagonists & inhibitors; Receptors, Calcium-Sensing - deficiency; Receptors, Calcium-Sensing - genetics; Receptors, Calcium-Sensing - physiology; RNA Interference; RNA, Small Interfering - genetics; RNA, Small Interfering - pharmacology; Spermine - biosynthesis; Spermine - physiology; Tobacco Smoke Pollution - adverse effects; Tobacco Smoking - adverse effects; endothelium; calcium-sensing receptor; spermine; pulmonary hypertension; smoking