Development of a canine model with diffuse hepatic vein obstruction (Budd-Chiari syndrome) via endovascular occlusion

• Published in: Molecular medicine reports Vol. 9; no. 2; pp. 607 - 613
• Main Authors: SHEN, BIN, ZHANG, QINGQIAO, WANG, XIAOLONG, XU, HAO, ZU, MAOHENG, WU, MENG, GAO, ZHIKANG, WANG, WENLIANG, XIAO, JINCHANG, WANG, YONG
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Angiography; animal model; Animals; Balloon catheters; Budd-Chiari syndrome; Budd-Chiari Syndrome - diagnostic imaging; Budd-Chiari Syndrome - genetics; Budd-Chiari Syndrome - pathology; Cardiovascular system; Care and treatment; Catheters; Diagnosis; Disease Models, Animal; Dogs; Edema; Health aspects; hepatic function; Hepatic vein; Hepatic vein thrombosis; Hepatic Veins - diagnostic imaging; Hepatic Veins - pathology; Hepatocytes; Humans; Jugular vein; Laboratory animals; Liver; Occlusion; portal hypertension; Radiography; Risk factors; Rodents; Studies; Surgery; Ultrasonic imaging; Veins & arteries; Velocity; China

The aim of the present study was to develop a reliable and reproducible canine model to mimic human diffuse hepatic vein obstruction (Budd-Chiari syndrome, BCS). A total of 24 canines were divided into an experimental (n=18) and a control (n=6) group. Under the guidance of digital subtraction angiog...