Latin American Study of Hereditary Breast and Ovarian Cancer LACAM : A Genomic Epidemiology Approach
Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop...
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| Published in | Frontiers in oncology Vol. 9; p. 1429 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
20.12.2019
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| Abstract | Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study.
We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms.
The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in
(20%) and
(29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as
, and
. Additional pathogenic variants were found in HBOC unrelated genes such as
, and
.
In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations. |
|---|---|
| AbstractList | Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study.
We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms.
The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in
(20%) and
(29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as
, and
. Additional pathogenic variants were found in HBOC unrelated genes such as
, and
.
In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations. Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms. Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH , and PALB2 . Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A , and PDGFB . Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations. Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study.Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms.Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH, and PALB2. Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A, and PDGFB.Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations. Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms. Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH, and PALB2. Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A, and PDGFB. Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations.Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms. Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH, and PALB2. Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A, and PDGFB. Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations. |
| Author | Oliver, Javier Castillo, Miluska Giraldo, Gustavo Gómez García, Eva María Gómez, Ana Milena Frecha, Cecilia Maya, Maria Isabel Pacheco-Orozco, Rafael Adrián Sanchez, Ana Isabel Orduz Galvis, Ana Isabel Torres Mejía, Gabriela Castañeda, Carlos Arturo Suarez Obando, Fernando Riggi, Cecilia Martínez Rizo, Abril Bernardette Zamora, Vanessa Romero Cruz, Luis Enrique Perdomo, Sandra Díaz Velásquez, Clara Estela Benites Godinez, Verónica Jauk, Federico Vallejo Lecuona, Fernando Romieu, Isabelle Méndez Catalá, Claudia Fabiola Quezada Urban, Rosalía Rojas Jiménez, Ernesto Herrera, Luis Alonso López Rivera, Juan Javier Hurtado-Villa, Paula Castro Rojas, Carlos Gitler, Rina Gaitán Chaparro, Sandra Antoniano, Adriana Serrano, Norma Aruachan, Sandra Chirino, Yolanda Irasema Delgado Enciso, Iván Vaca Paniagua, Felipe Montealegre Paez, Ana Lorena Franco Cortés, Claudia Alejandra Carranza, Claudia Lorena Terrazas, Luis Ignacio García-Robles, Reggie Nuñez Castillo, Johanna Flores Carranza, Alejandro |
| AuthorAffiliation | 18 Centro Oncológico Estatal ISSEMyM , Toluca de Lerdo , Mexico 23 Departamento de Investigación, Instituto Nacional de Enfermedades Neoplásicas , Lima , Peru 12 Centro Médico Imbanaco , Cali , Colombia 5 Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque , Bogota , Colombia 27 Instituto Mexicano del Seguro Social , Ciudad de México , Mexico 21 Hubert Department of Global Health, Emory University , Atlanta, GA , United States 25 Instituto Estatal de Cancerología de Colima , Colima , Mexico 9 Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana , Bogotá , Colombia 11 Departamento Ciencias Básicas de Salud, Facultad de Ciencias de la Salud, Pontificia Universidad Javeriana Cali , Cali , Colombia 17 Servicio de Ginecología, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina 20 Instituto Nacional de Salud Pública , Cuernavaca , Mexico 14 Fundación Cardiovascular de Colombia, Centro de Investigaciones , Floridablanca , |
| AuthorAffiliation_xml | – name: 15 Departamento de Investigación y Estudios Clínicos, IMAT - Oncomédica S.A. , Montería , Colombia – name: 21 Hubert Department of Global Health, Emory University , Atlanta, GA , United States – name: 6 Grupo INPAC, Organización Keralty, Departamento de Genética, Clínica Universitaria Colombia , Bogotá , Colombia – name: 9 Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana , Bogotá , Colombia – name: 14 Fundación Cardiovascular de Colombia, Centro de Investigaciones , Floridablanca , Colombia – name: 17 Servicio de Ginecología, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina – name: 20 Instituto Nacional de Salud Pública , Cuernavaca , Mexico – name: 28 Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas-Instituto Nacional de Cancerología , Ciudad de México , Mexico – name: 3 Laboratorio Nacional en Salud, Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala , Tlalnepantla de Baz , Mexico – name: 8 Servicio de Genética, Hospital Universitario San Ignacio , Bogotá , Colombia – name: 13 Departamento Materno Infantil, Facultad de Ciencias de la Salud, Pontificia Universidad Javeriana Cali , Cali , Colombia – name: 5 Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque , Bogota , Colombia – name: 10 Clínica Universitaria Bolivariana, Pontificia Universidad Bolivariana , Medellín , Colombia – name: 25 Instituto Estatal de Cancerología de Colima , Colima , Mexico – name: 4 Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM , Tlalnepantla de Baz , Mexico – name: 30 Instituto Nacional de Cancerología , Ciudad de México , Mexico – name: 7 Grupo INPAC, Organización Keralty, Facultad de Medicina, Fundación Universitaria Sanitas , Bogotá , Colombia – name: 27 Instituto Mexicano del Seguro Social , Ciudad de México , Mexico – name: 24 Fundación Alma , Ciudad de México , Mexico – name: 22 Departamento de Oncología Médica, Instituto Nacional de Enfermedades Neoplásicas , Lima , Peru – name: 29 Departamento de Patología, Hospital Universitario Fundación Santa Fe de Bogotá , Bogota , Colombia – name: 1 Medical Oncology Service, Hospitales Universitarios Regional y Virgen de la Victoria, Institute of Biomedical Research in Malaga, CIMES, University of Málaga , Málaga , Spain – name: 18 Centro Oncológico Estatal ISSEMyM , Toluca de Lerdo , Mexico – name: 16 Instituto de Medicina Traslacional e Ingeniería Biomédica, CONICET-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires , Buenos Aires , Argentina – name: 12 Centro Médico Imbanaco , Cali , Colombia – name: 23 Departamento de Investigación, Instituto Nacional de Enfermedades Neoplásicas , Lima , Peru – name: 19 INVEGEM , Guatemala , Guatemala – name: 2 Laboratorio de Secuenciación, Instituto de Medicina Traslacional e Ingeniería Biomédica, Hospital Italiano de Buenos Aires , Buenos Aires , Argentina – name: 26 Laboratorio de Investigación Biomédica, Unidad Académica de Medicina, Universidad Autónoma de Nayarit , Tepic , Mexico – name: 11 Departamento Ciencias Básicas de Salud, Facultad de Ciencias de la Salud, Pontificia Universidad Javeriana Cali , Cali , Colombia |
| Author_xml | – sequence: 1 givenname: Javier surname: Oliver fullname: Oliver, Javier organization: Laboratorio Nacional en Salud, Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Mexico – sequence: 2 givenname: Rosalía surname: Quezada Urban fullname: Quezada Urban, Rosalía organization: Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla de Baz, Mexico – sequence: 3 givenname: Claudia Alejandra surname: Franco Cortés fullname: Franco Cortés, Claudia Alejandra organization: Laboratorio de Secuenciación, Instituto de Medicina Traslacional e Ingeniería Biomédica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina – sequence: 4 givenname: Clara Estela surname: Díaz Velásquez fullname: Díaz Velásquez, Clara Estela organization: Laboratorio Nacional en Salud, Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala, Tlalnepantla de Baz, Mexico – sequence: 5 givenname: Ana Lorena surname: Montealegre Paez fullname: Montealegre Paez, Ana Lorena organization: Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque, Bogota, Colombia – sequence: 6 givenname: Rafael Adrián surname: Pacheco-Orozco fullname: Pacheco-Orozco, Rafael Adrián organization: Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque, Bogota, Colombia – sequence: 7 givenname: Carlos surname: Castro Rojas fullname: Castro Rojas, Carlos organization: Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque, Bogota, Colombia – sequence: 8 givenname: Reggie surname: García-Robles fullname: García-Robles, Reggie organization: Instituto de Nutrición, Genética y Metabolismo, Facultad de Medicina, Universidad El Bosque, Bogota, Colombia – sequence: 9 givenname: Juan Javier surname: López Rivera fullname: López Rivera, Juan Javier organization: Grupo INPAC, Organización Keralty, Departamento de Genética, Clínica Universitaria Colombia, Bogotá, Colombia – sequence: 10 givenname: Sandra surname: Gaitán Chaparro fullname: Gaitán Chaparro, Sandra organization: Grupo INPAC, Organización Keralty, Facultad de Medicina, Fundación Universitaria Sanitas, Bogotá, Colombia – sequence: 11 givenname: Ana Milena surname: Gómez fullname: Gómez, Ana Milena organization: Servicio de Genética, Hospital Universitario San Ignacio, Bogotá, Colombia – sequence: 12 givenname: Fernando surname: Suarez Obando fullname: Suarez Obando, Fernando organization: Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia – sequence: 13 givenname: Gustavo surname: Giraldo fullname: Giraldo, Gustavo organization: Clínica Universitaria Bolivariana, Pontificia Universidad Bolivariana, Medellín, Colombia – sequence: 14 givenname: Maria Isabel surname: Maya fullname: Maya, Maria Isabel organization: Clínica Universitaria Bolivariana, Pontificia Universidad Bolivariana, Medellín, Colombia – sequence: 15 givenname: Paula surname: Hurtado-Villa fullname: Hurtado-Villa, Paula organization: Centro Médico Imbanaco, Cali, Colombia – sequence: 16 givenname: Ana Isabel surname: Sanchez fullname: Sanchez, Ana Isabel organization: Departamento Materno Infantil, Facultad de Ciencias de la Salud, Pontificia Universidad Javeriana Cali, Cali, Colombia – sequence: 17 givenname: Norma surname: Serrano fullname: Serrano, Norma organization: Fundación Cardiovascular de Colombia, Centro de Investigaciones, Floridablanca, Colombia – sequence: 18 givenname: Ana Isabel surname: Orduz Galvis fullname: Orduz Galvis, Ana Isabel organization: Fundación Cardiovascular de Colombia, Centro de Investigaciones, Floridablanca, Colombia – sequence: 19 givenname: Sandra surname: Aruachan fullname: Aruachan, Sandra organization: Departamento de Investigación y Estudios Clínicos, IMAT - 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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31921681$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua. Copyright © 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua. 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua |
| Copyright_xml | – notice: Copyright © 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua. – notice: Copyright © 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua. 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua |
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| Keywords | germline pathogenic variants breast cancer susceptibility massively parallel sequencing HBOC Latin America |
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| License | Copyright © 2019 Oliver, Quezada Urban, Franco Cortés, Díaz Velásquez, Montealegre Paez, Pacheco-Orozco, Castro Rojas, García-Robles, López Rivera, Gaitán Chaparro, Gómez, Suarez Obando, Giraldo, Maya, Hurtado-Villa, Sanchez, Serrano, Orduz Galvis, Aruachan, Nuñez Castillo, Frecha, Riggi, Jauk, Gómez García, Carranza, Zamora, Torres Mejía, Romieu, Castañeda, Castillo, Gitler, Antoniano, Rojas Jiménez, Romero Cruz, Vallejo Lecuona, Delgado Enciso, Martínez Rizo, Flores Carranza, Benites Godinez, Méndez Catalá, Herrera, Chirino, Terrazas, Perdomo and Vaca Paniagua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Snippet | Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common... Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most... Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most... Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most... |
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| Title | Latin American Study of Hereditary Breast and Ovarian Cancer LACAM : A Genomic Epidemiology Approach |
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