Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system

• Published in: Infection Vol. 52; no. 5; pp. 1875 - 1887
• Main Authors: Wu, Luling, Fu, Xuemin, Pütz, Benno, Zhang, Renfang, Liu, Li, Song, Wei, Weng, Ling, Shao, Yueming, Zheng, Zhihang, Xun, Jingna, Han, Ximei, Wang, Ting, Shen, Yinzhong, Lu, Hongzhou, Müller-Myhsok, Bertram, Chen, Jun
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Adult; AIDS-Related Opportunistic Infections - microbiology; AIDS-Related Opportunistic Infections - mortality; Antifungal agents; antiretroviral agents; Biomarkers; Central nervous system; Cohort Studies; Comparative analysis; Cryptococcosis; Cryptococcosis - drug therapy; Cryptococcosis - mortality; Family Medicine; Female; Fungicides; General Practice; HIV; HIV Infections - complications; HIV Infections - mortality; Human immunodeficiency virus; Humans; Immunology; infection; Infectious Diseases; Interleukin 1 receptor antagonist; Interleukin 1 receptors; interleukin-6; Internal Medicine; Lung - microbiology; Lung - pathology; Lung diseases; Lung Diseases, Fungal - microbiology; Lung Diseases, Fungal - mortality; Lungs; Male; Medicine; Medicine & Public Health; Middle Aged; Monocyte chemoattractant protein 1; Mortality; Nervous system; Performance prediction; Plasma levels; Predictions; Regression analysis; Regression models; Risk Factors; Survival; Survival Analysis; Therapeutic targets; therapeutics; HIV/AIDS; Disseminated cryptococcosis; Three-year survival-related predictions; Antiretroviral and antifungal drug therapies

Background The global mortality rate resulting from HIV-associated cryptococcal disease is remarkably elevated, particularly in severe cases with dissemination to the lungs and central nervous system (CNS). Regrettably, there is a dearth of predictive analysis regarding long-term survival, and few s...