Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131

• Published in: Molecular medicine reports Vol. 12; no. 5; pp. 7673 - 7680
• Main Authors: GUO, KUN, GAO, RUI, YU, YAN, ZHANG, WEIXIAO, YANG, YUXUAN, YANG, AIMIN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.11.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Apoptosis; Ataxia; Ataxia telangiectasia mutated protein; B cell lymphoma 2; B-cell lymphoma; Bcl-2 protein; Development and progression; Drug dosages; early growth response 1; Early Growth Response Protein 1 - genetics; early-stage hypothyroidism; EGR-1 protein; Epidermal growth factor; Epidermal growth factor receptors; Female; Gene Expression; Genes; Genetic aspects; Health aspects; Hormones; Humans; Hyperthyroidism; Hyperthyroidism - drug therapy; Hyperthyroidism - genetics; Hypothyroidism; Hypothyroidism - chemically induced; Hypothyroidism - diagnosis; Hypothyroidism - genetics; Iodine; Iodine compounds; Iodine Radioisotopes - adverse effects; Iodine Radioisotopes - therapeutic use; Laboratories; Lymphocytes B; Lymphoma; Male; Medical prognosis; Messenger RNA; Middle Aged; p53 Protein; Patients; Polymerase chain reaction; Proteins; Proto-Oncogene Proteins c-bcl-2 - genetics; radioiodine; Reverse transcription; RNA, Messenger - genetics; Signal transduction; Thyroid gland; Tumors
• ISSN: 1791-2997; 1791-3004; 1791-3004
• DOI: 10.3892/mmr.2015.4350

The present study aimed to investigate the molecular markers indicative of early-stage hypothyroidism induced by treatment with iodine-131, in order to assist in further investigations of radio iodine-induced hypothyroidism. A total of 59 patients diagnosed with hyperthyroidism (male/female, 16/43;...