Are seronegative patients with rheumatoid arthritis and clinically suspect arthralgia properly represented in randomized clinical trials?

• Published in: Clinical rheumatology Vol. 44; no. 1; pp. 515 - 519
• Main Authors: D’Onofrio, Bernardo, Selmi, Carlo, Gremese, Elisa
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2025; Springer Nature B.V
• Subjects: Anti-Citrullinated Protein Antibodies - blood; Arthralgia; Arthralgia - blood; Arthralgia - diagnosis; Arthralgia - immunology; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - immunology; Autoantibodies; Autoantibodies - blood; blood serum; Citrulline; Clinical trials; Humans; Inflammatory diseases; Medicine; Medicine & Public Health; mortality; pathogenesis; Patients; peptides; Perspectives in Rheumatology; Prognosis; radiography; Randomized Controlled Trials as Topic; Rheumatoid arthritis; Rheumatoid factor; Rheumatoid Factor - blood; Rheumatology; risk; s in Rheumatology; seroprevalence; Serotypes; Autoantibodies; Clinically suspect arthralgia; ACPA; Rheumatoid arthritis; Randomized controlled trials

Rheumatoid arthritis (RA) is a chronic immuno-inflammatory disease whose outcomes can vary greatly from one patient to another. One of the main prognostic factors is the presence of serum autoantibodies, such as rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA). Indeed, when se...