Role of the anti-glioma drug AT13148 in the inhibition of Notch signaling pathway

• Published in: Gene Vol. 573; no. 1; pp. 153 - 159
• Main Authors: Min, Weijie, Li, Yanan, Zhang, Yihui, Dai, Dongwei, Cao, Yiqun, Yue, Zhijian, Liu, Jianmin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2015
• Subjects: 2-Hydroxyphenethylamine - analogs & derivatives; 2-Hydroxyphenethylamine - pharmacology; Antineoplastic Agents - pharmacology; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; cell cycle; data collection; Differentially expressed genes; DNA replication; Drug target; drugs; gene expression; gene expression regulation; genes; Glioma; Glioma - metabolism; Glioma - pathology; Humans; microarray technology; Notch signaling pathway; Pyrazoles - pharmacology; Receptors, Notch - metabolism; signal transduction; MAML1-dn; MAML1; ROCK2; DTX1; EGFP; TFPI; NF-κB; DEGs; Differentially expressed genes; IMPA1; FDR; NCBI; KDR; KEGG; ASL; ACSS1; PDGFRB; Notch signaling pathway; STAT3; GO; Drug target; GS; PCA; GEO; GBMg; Glioma; GCLM

To investigate the drug targets related to Notch signaling pathway for glioma treatment. Gene expression profiles GSE44561, GSE48079 and GSE22772GSE48079GSE22772 of glioma cells samples with activated Notch signaling pathway and control samples were downloaded from Gene Expression Omnibus database t...